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4YV8

Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue SO4 A 301
ChainResidue
AASN18
AHOH426
AARG108
AARG111
AGLY185
AGLU186
AASN187
ALYS214
AHOH419
AHOH421

site_idAC2
Number of Residues9
Detailsbinding site for residue SO4 A 302
ChainResidue
AGLN19
AARG127
AHIS162
ATRP184
AHOH414
AHOH436
AHOH499
BRGL5
BHOH102

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 A 303
ChainResidue
AASN117
ALYS119
AARG123

site_idAC4
Number of Residues23
Detailsbinding site for Lichostatinal chain B
ChainResidue
AGLN19
AGLY23
ASER24
ACYS25
ALYS44
ACYS63
AGLY64
AGLY65
AGLY66
ATYR67
ASER83
AGLY102
ALYS103
AALA104
AGLU115
ALEU160
AASN161
AALA163
ASO4302
AHOH425
AHOH464
BHOH101
BHOH102

Functional Information from PROSITE/UniProt
site_idPS00139
Number of Residues12
DetailsTHIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSS
ChainResidueDetails
AGLN19-SER30

site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVLAVGYG
ChainResidueDetails
ALEU160-GLY170

site_idPS00640
Number of Residues20
DetailsTHIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. HWIiKNSWgenWGnkGYIlM
ChainResidueDetails
AHIS177-MET196

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
ACYS25
AHIS162
AASN182

224931

PDB entries from 2024-09-11

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