4YUB
Crystal structure of human Nicotinic Acid Phosphoribosyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004516 | molecular_function | nicotinate phosphoribosyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0009435 | biological_process | NAD biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016874 | molecular_function | ligase activity |
| A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| A | 0034355 | biological_process | NAD salvage |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0004516 | molecular_function | nicotinate phosphoribosyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0009435 | biological_process | NAD biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016874 | molecular_function | ligase activity |
| B | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| B | 0034355 | biological_process | NAD salvage |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9HJ28 |
| Chain | Residue | Details |
| A | TYR21 | |
| A | THR210 | |
| A | ARG318 | |
| A | THR380 | |
| B | TYR21 | |
| B | THR210 | |
| B | ARG318 | |
| B | THR380 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphohistidine => ECO:0000250|UniProtKB:P22253 |
| Chain | Residue | Details |
| A | HIS213 | |
| B | HIS213 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER537 | |
| B | SER537 |
