4YTA

BOND LENGTH ANALYSIS OF ASP, GLU AND HIS RESIDUES IN TRYPSIN AT 1.2A RESOLUTION

Replaces:  3UNR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004175	molecular_function	endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0007586	biological_process	digestion
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0097180	cellular_component	serine protease inhibitor complex
A	0097655	molecular_function	serpin family protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue GOL A 301

Chain	Residue
A	ASN97
A	HOH425
A	HOH428
A	THR98
A	LEU99
A	LYS157
A	GLN173
A	TRP215
A	GOL302
A	HOH406
A	HOH422

---

site_id	AC2
Number of Residues	10
Details	binding site for residue GOL A 302

Chain	Residue
A	TYR20
A	CYS22
A	THR26
A	ASN97
A	LEU135
A	GLN173
A	GOL301
A	HOH406
A	HOH428
A	HOH447

---

site_id	AC3
Number of Residues	2
Details	binding site for residue SO4 A 303

Chain	Residue
A	ILE47
A	ASN48

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA A 304

Chain	Residue
A	GLU70
A	ASN72
A	VAL75
A	GLU80
A	HOH579
A	HOH599

---

site_id	AC5
Number of Residues	9
Details	binding site for residue SO4 A 305

Chain	Residue
A	PRO124
A	THR125
A	SER126
A	SER145
A	GLY146
A	LYS204
A	HOH456
A	HOH467
A	HOH489

---

site_id	AC6
Number of Residues	8
Details	binding site for residue SO4 A 306

Chain	Residue
A	HIS57
A	GLN192
A	GLY193
A	SER195
A	BEN312
A	HOH448
A	HOH596
A	HOH647

---

site_id	AC7
Number of Residues	9
Details	binding site for residue SO4 A 307

Chain	Residue
A	LYS87
A	LYS107
A	THR147
A	TYR149
A	HOH426
A	HOH450
A	HOH451
A	HOH477
A	HOH502

---

site_id	AC8
Number of Residues	6
Details	binding site for residue SO4 A 308

Chain	Residue
A	LYS143
A	SER144
A	SER145
A	HOH696
A	HOH713
A	HOH718

---

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 A 309

Chain	Residue
A	THR175
A	SER176
A	HOH620
A	HOH683

---

site_id	AD1
Number of Residues	7
Details	binding site for residue SO4 A 310

Chain	Residue
A	LYS167
A	PRO171
A	GLY172
A	HOH446
A	HOH533
A	HOH593
A	HOH692

---

site_id	AD2
Number of Residues	7
Details	binding site for residue SO4 A 311

Chain	Residue
A	ASN95
A	THR98
A	ASN100
A	HOH629
A	HOH649
A	HOH650
A	HOH676

---

site_id	AD3
Number of Residues	9
Details	binding site for residue BEN A 312

Chain	Residue
A	ASP189
A	SER190
A	GLN192
A	SER195
A	GLY218
A	CYS219
A	GLY226
A	SO4306
A	HOH584

---

site_id	AD4
Number of Residues	4
Details	binding site for residue GOL A 313

Chain	Residue
A	GLU80
A	GLN81
A	PHE82
A	HOH539

---

site_id	AD5
Number of Residues	9
Details	binding site for residue GOL A 314

Chain	Residue
A	HOH693
A	HOH731
A	THR142
A	PRO150
A	LYS154
A	HOH585
A	HOH611
A	HOH617
A	HOH634

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
A	VAL53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV

Chain	Residue	Details
A	ASP189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	220
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {}

Chain

Residue

Details

---