Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0007586 | biological_process | digestion |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0097180 | cellular_component | serine protease inhibitor complex |
| A | 0097655 | molecular_function | serpin family protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | ASN97 |
| A | HOH425 |
| A | HOH428 |
| A | THR98 |
| A | LEU99 |
| A | LYS157 |
| A | GLN173 |
| A | TRP215 |
| A | GOL302 |
| A | HOH406 |
| A | HOH422 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | TYR20 |
| A | CYS22 |
| A | THR26 |
| A | ASN97 |
| A | LEU135 |
| A | GLN173 |
| A | GOL301 |
| A | HOH406 |
| A | HOH428 |
| A | HOH447 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 303 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 304 |
| Chain | Residue |
| A | GLU70 |
| A | ASN72 |
| A | VAL75 |
| A | GLU80 |
| A | HOH579 |
| A | HOH599 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | PRO124 |
| A | THR125 |
| A | SER126 |
| A | SER145 |
| A | GLY146 |
| A | LYS204 |
| A | HOH456 |
| A | HOH467 |
| A | HOH489 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 306 |
| Chain | Residue |
| A | HIS57 |
| A | GLN192 |
| A | GLY193 |
| A | SER195 |
| A | BEN312 |
| A | HOH448 |
| A | HOH596 |
| A | HOH647 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 307 |
| Chain | Residue |
| A | LYS87 |
| A | LYS107 |
| A | THR147 |
| A | TYR149 |
| A | HOH426 |
| A | HOH450 |
| A | HOH451 |
| A | HOH477 |
| A | HOH502 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 308 |
| Chain | Residue |
| A | LYS143 |
| A | SER144 |
| A | SER145 |
| A | HOH696 |
| A | HOH713 |
| A | HOH718 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 309 |
| Chain | Residue |
| A | THR175 |
| A | SER176 |
| A | HOH620 |
| A | HOH683 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 310 |
| Chain | Residue |
| A | LYS167 |
| A | PRO171 |
| A | GLY172 |
| A | HOH446 |
| A | HOH533 |
| A | HOH593 |
| A | HOH692 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 311 |
| Chain | Residue |
| A | ASN95 |
| A | THR98 |
| A | ASN100 |
| A | HOH629 |
| A | HOH649 |
| A | HOH650 |
| A | HOH676 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue BEN A 312 |
| Chain | Residue |
| A | ASP189 |
| A | SER190 |
| A | GLN192 |
| A | SER195 |
| A | GLY218 |
| A | CYS219 |
| A | GLY226 |
| A | SO4306 |
| A | HOH584 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 313 |
| Chain | Residue |
| A | GLU80 |
| A | GLN81 |
| A | PHE82 |
| A | HOH539 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 314 |
| Chain | Residue |
| A | HOH693 |
| A | HOH731 |
| A | THR142 |
| A | PRO150 |
| A | LYS154 |
| A | HOH585 |
| A | HOH611 |
| A | HOH617 |
| A | HOH634 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC |
| Chain | Residue | Details |
| A | VAL53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV |
| Chain | Residue | Details |
| A | ASP189-VAL200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS57 | |
| A | ASP102 | |
| A | SER195 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLU70 | |
| A | ASN72 | |
| A | VAL75 | |
| A | GLU80 | |
| A | ASP189 | |
| A | GLN192 | |
| A | SER195 | |
