4YRT
Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with N-(5-hydroxynaphthalen-2-yl)propanamide (Chem 1781)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004821 | molecular_function | histidine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006412 | biological_process | translation |
| A | 0006427 | biological_process | histidyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue HIS A 501 |
| Chain | Residue |
| A | GLU126 |
| A | GLY359 |
| A | PHE360 |
| A | GLY361 |
| A | HOH640 |
| A | HOH649 |
| A | HOH656 |
| A | HOH671 |
| A | THR128 |
| A | GLN170 |
| A | ASN172 |
| A | ASP174 |
| A | LEU316 |
| A | TYR318 |
| A | TYR319 |
| A | TYR342 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue 781 A 502 |
| Chain | Residue |
| A | CYS154 |
| A | ARG156 |
| A | ARG166 |
| A | GLU167 |
| A | HIS168 |
| A | CYS365 |
| A | VAL366 |
| A | HOH604 |
| A | HOH725 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | ARG69 |
| A | ARG69 |
| A | PHE72 |
| A | HIS76 |
| A | HOH608 |
| A | HOH608 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | THR115 |
| A | GLY117 |
| A | HIS119 |
| A | TYR157 |
| A | ARG166 |
