4YRB
mouse TDH mutant R180K with NAD+ bound
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue NAD A 1001 |
| Chain | Residue |
| A | GLY65 |
| A | ILE107 |
| A | TYR128 |
| A | SER129 |
| A | ALA130 |
| A | LEU132 |
| A | VAL146 |
| A | THR170 |
| A | TYR195 |
| A | LYS199 |
| A | ILE225 |
| A | GLN66 |
| A | LEU67 |
| A | GLY68 |
| A | ASP88 |
| A | ILE89 |
| A | ARG90 |
| A | ALA105 |
| A | ASN106 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | binding site for residue NAD B 1001 |
| Chain | Residue |
| B | GLY62 |
| B | LEU64 |
| B | GLY65 |
| B | GLN66 |
| B | LEU67 |
| B | ASP88 |
| B | ILE89 |
| B | ARG90 |
| B | ALA105 |
| B | ASN106 |
| B | ILE107 |
| B | TYR128 |
| B | SER129 |
| B | ALA130 |
| B | LEU132 |
| B | PRO168 |
| B | SER169 |
| B | THR170 |
| B | TYR195 |
| B | LYS199 |
| B | TYR222 |
| B | PRO223 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | binding site for residue NAD C 1001 |
| Chain | Residue |
| C | GLY62 |
| C | GLY65 |
| C | GLN66 |
| C | LEU67 |
| C | ASP88 |
| C | ILE89 |
| C | ARG90 |
| C | ALA105 |
| C | ASN106 |
| C | ILE107 |
| C | TYR128 |
| C | SER129 |
| C | ALA130 |
| C | LEU132 |
| C | VAL146 |
| C | PRO168 |
| C | TYR195 |
| C | LYS199 |
| C | PRO223 |
| C | ILE225 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | binding site for residue NAD D 1001 |
| Chain | Residue |
| D | GLY62 |
| D | GLY65 |
| D | GLN66 |
| D | LEU67 |
| D | ASP88 |
| D | ILE89 |
| D | ARG90 |
| D | ALA105 |
| D | ASN106 |
| D | ILE107 |
| D | TYR128 |
| D | SER129 |
| D | ALA130 |
| D | LEU132 |
| D | PRO168 |
| D | SER169 |
| D | TYR195 |
| D | LYS199 |
| D | TYR222 |
| D | PRO223 |
| D | ILE225 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | binding site for residue NAD E 1001 |
| Chain | Residue |
| E | THR170 |
| E | TYR195 |
| E | LYS199 |
| E | ILE225 |
| E | GLY62 |
| E | LEU64 |
| E | GLY65 |
| E | GLN66 |
| E | LEU67 |
| E | ASP88 |
| E | ILE89 |
| E | ARG90 |
| E | ALA105 |
| E | ASN106 |
| E | ILE107 |
| E | TYR128 |
| E | SER129 |
| E | ALA130 |
| E | VAL146 |
| E | PRO168 |
| E | SER169 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | binding site for residue NAD F 1001 |
| Chain | Residue |
| F | GLY65 |
| F | GLN66 |
| F | ASP88 |
| F | ILE89 |
| F | ARG90 |
| F | ALA105 |
| F | ASN106 |
| F | ILE107 |
| F | TYR128 |
| F | SER129 |
| F | ALA130 |
| F | LEU132 |
| F | PRO168 |
| F | TYR195 |
| F | PRO223 |
| F | ILE225 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"26492815","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 66 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26492815","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YR9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YRA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YRB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
