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4YQM

Glutathione S-transferase Omega 1 bound to covalent inhibitor C1-27

Functional Information from GO Data
ChainGOidnamespacecontents
A0004364molecular_functionglutathione transferase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006749biological_processglutathione metabolic process
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0014810biological_processpositive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0019852biological_processL-ascorbic acid metabolic process
A0042178biological_processxenobiotic catabolic process
A0045174molecular_functionglutathione dehydrogenase (ascorbate) activity
A0050610molecular_functionmethylarsonate reductase activity
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
A0070062cellular_componentextracellular exosome
A0071243biological_processcellular response to arsenic-containing substance
A0098869biological_processcellular oxidant detoxification
B0004364molecular_functionglutathione transferase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006749biological_processglutathione metabolic process
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0014810biological_processpositive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0019852biological_processL-ascorbic acid metabolic process
B0042178biological_processxenobiotic catabolic process
B0045174molecular_functionglutathione dehydrogenase (ascorbate) activity
B0050610molecular_functionmethylarsonate reductase activity
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
B0070062cellular_componentextracellular exosome
B0071243biological_processcellular response to arsenic-containing substance
B0098869biological_processcellular oxidant detoxification
C0004364molecular_functionglutathione transferase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006749biological_processglutathione metabolic process
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0014810biological_processpositive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
C0016491molecular_functionoxidoreductase activity
C0016740molecular_functiontransferase activity
C0019852biological_processL-ascorbic acid metabolic process
C0042178biological_processxenobiotic catabolic process
C0045174molecular_functionglutathione dehydrogenase (ascorbate) activity
C0050610molecular_functionmethylarsonate reductase activity
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
C0070062cellular_componentextracellular exosome
C0071243biological_processcellular response to arsenic-containing substance
C0098869biological_processcellular oxidant detoxification
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue 4G9 A 301
ChainResidue
ACYS32
APRO33
APHE34
AVAL127
AGLY128
AARG132
ATRP180

site_idAC2
Number of Residues6
Detailsbinding site for residue MES A 302
ChainResidue
APRO73
AGLU85
ASER86
AGLU118
APHE34
APHE69

site_idAC3
Number of Residues6
Detailsbinding site for residue MES B 302
ChainResidue
BPHE34
BPHE69
BGLU85
BSER86
BHOH431
CGLU118

site_idAC4
Number of Residues6
Detailsbinding site for residue MES C 302
ChainResidue
BGLU118
CPHE34
CPHE69
CPRO73
CGLU85
CSER86

site_idAC5
Number of Residues11
Detailsbinding site for Di-peptide 4G9 B 301 and CYS B 32
ChainResidue
BMET29
BARG30
BPHE31
BPRO33
BPHE34
BGLU36
BPRO124
BVAL127
BTRP180
BTYR229
BHOH405

site_idAC6
Number of Residues11
Detailsbinding site for Di-peptide 4G9 C 301 and CYS C 32
ChainResidue
CMET29
CARG30
CPHE31
CPRO33
CPHE34
CGLU36
CPRO124
CVAL127
CILE131
CTRP180
CHOH408

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:10783391
ChainResidueDetails
ACYS32
BCYS32
CCYS32

site_idSWS_FT_FI2
Number of Residues9
DetailsBINDING: BINDING => ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:21106529
ChainResidueDetails
ALYS59
AVAL72
AGLU85
BLYS59
BVAL72
BGLU85
CLYS59
CVAL72
CGLU85

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330
ChainResidueDetails
ASER2
BSER2
CSER2

site_idSWS_FT_FI4
Number of Residues12
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS57
CLYS143
CLYS148
CLYS152
ALYS143
ALYS148
ALYS152
BLYS57
BLYS143
BLYS148
BLYS152
CLYS57

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER129
BSER129
CSER129

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PDB entries from 2024-10-09

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