4YPL
Crystal structure of a hexameric LonA protease bound to three ADPs
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004176 | molecular_function | ATP-dependent peptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006508 | biological_process | proteolysis |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030163 | biological_process | protein catabolic process |
| B | 0004176 | molecular_function | ATP-dependent peptidase activity |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006508 | biological_process | proteolysis |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0030163 | biological_process | protein catabolic process |
| C | 0004176 | molecular_function | ATP-dependent peptidase activity |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006508 | biological_process | proteolysis |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0030163 | biological_process | protein catabolic process |
| D | 0004176 | molecular_function | ATP-dependent peptidase activity |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006508 | biological_process | proteolysis |
| D | 0016887 | molecular_function | ATP hydrolysis activity |
| D | 0030163 | biological_process | protein catabolic process |
| E | 0004176 | molecular_function | ATP-dependent peptidase activity |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0006508 | biological_process | proteolysis |
| E | 0016887 | molecular_function | ATP hydrolysis activity |
| E | 0030163 | biological_process | protein catabolic process |
| F | 0004176 | molecular_function | ATP-dependent peptidase activity |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0006508 | biological_process | proteolysis |
| F | 0016887 | molecular_function | ATP hydrolysis activity |
| F | 0030163 | biological_process | protein catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue 4KZ A 801 |
| Chain | Residue |
| A | ALA601 |
| A | ALA679 |
| A | LYS721 |
| A | TRP602 |
| A | LEU610 |
| A | MET633 |
| A | LYS674 |
| A | ASP675 |
| A | GLY676 |
| A | PRO677 |
| A | SER678 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue ADP B 801 |
| Chain | Residue |
| B | HIS319 |
| B | TYR320 |
| B | LEU322 |
| B | PRO357 |
| B | GLY358 |
| B | VAL359 |
| B | GLY360 |
| B | LYS361 |
| B | THR362 |
| B | SER363 |
| B | TYR493 |
| B | ILE501 |
| B | LYS509 |
| B | VAL540 |
| B | ARG541 |
| B | GLU544 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue ADP F 801 |
| Chain | Residue |
| F | HIS319 |
| F | TYR320 |
| F | GLY358 |
| F | VAL359 |
| F | GLY360 |
| F | LYS361 |
| F | THR362 |
| F | SER363 |
| F | TYR493 |
| F | ILE501 |
| F | LEU506 |
| F | VAL540 |
| F | ARG541 |
| F | GLU544 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue ADP D 801 |
| Chain | Residue |
| D | HIS319 |
| D | TYR320 |
| D | GLY358 |
| D | VAL359 |
| D | GLY360 |
| D | LYS361 |
| D | THR362 |
| D | SER363 |
| D | TYR493 |
| D | ILE501 |
| D | TYR505 |
| D | VAL540 |
| D | ARG541 |
| D | GLU544 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide 4KZ B 802 and SER B 678 |
| Chain | Residue |
| B | LEU600 |
| B | ALA601 |
| B | TRP602 |
| B | THR603 |
| B | LEU610 |
| B | MET633 |
| B | LYS674 |
| B | ASP675 |
| B | GLY676 |
| B | PRO677 |
| B | ALA679 |
| B | GLY680 |
| B | THR703 |
| B | GLY704 |
| B | LYS721 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide 4KZ C 801 and SER C 678 |
| Chain | Residue |
| C | LEU600 |
| C | ALA601 |
| C | TRP602 |
| C | THR603 |
| C | THR608 |
| C | LEU610 |
| C | MET633 |
| C | PRO673 |
| C | LYS674 |
| C | ASP675 |
| C | GLY676 |
| C | PRO677 |
| C | ALA679 |
| C | GLY680 |
| C | THR703 |
| C | GLY704 |
| C | GLU705 |
| C | LYS721 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide 4KZ D 802 and SER D 678 |
| Chain | Residue |
| D | GLY680 |
| D | THR703 |
| D | GLY704 |
| D | LYS721 |
| D | ALA601 |
| D | TRP602 |
| D | THR603 |
| D | THR608 |
| D | MET633 |
| D | PRO673 |
| D | LYS674 |
| D | ASP675 |
| D | GLY676 |
| D | PRO677 |
| D | ALA679 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide 4KZ E 801 and SER E 678 |
| Chain | Residue |
| E | LEU600 |
| E | ALA601 |
| E | TRP602 |
| E | THR603 |
| E | MET633 |
| E | THR672 |
| E | PRO673 |
| E | LYS674 |
| E | ASP675 |
| E | GLY676 |
| E | PRO677 |
| E | ALA679 |
| E | GLY680 |
| E | THR703 |
| E | GLY704 |
| E | LYS721 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide 4KZ F 802 and SER F 678 |
| Chain | Residue |
| F | LEU600 |
| F | ALA601 |
| F | TRP602 |
| F | THR608 |
| F | LYS674 |
| F | ASP675 |
| F | GLY676 |
| F | PRO677 |
| F | ALA679 |
| F | GLY680 |
| F | THR703 |
| F | GLY704 |
| F | ILE715 |
| F | LYS721 |
Functional Information from PROSITE/UniProt
| site_id | PS01046 |
| Number of Residues | 9 |
| Details | LON_SER ATP-dependent serine proteases, lon family, serine active site. DGPSAGITM |
| Chain | Residue | Details |
| A | ASP675-MET683 |
