4YPA

ASH1L SET domain Q2265A mutant in complex with S-adenosyl methionine (SAM)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0042054	molecular_function	histone methyltransferase activity
B	0005634	cellular_component	nucleus
B	0042054	molecular_function	histone methyltransferase activity
C	0005634	cellular_component	nucleus
C	0042054	molecular_function	histone methyltransferase activity
D	0005634	cellular_component	nucleus
D	0042054	molecular_function	histone methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 3001

Chain	Residue
A	CYS2091
A	CYS2093
A	CYS2104
A	CYS2108

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 3002

Chain	Residue
A	CYS2104
A	CYS2117
A	CYS2122
A	CYS2128

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 3003

Chain	Residue
A	CYS2268
A	CYS2270
A	CYS2275
A	CYS2220

---

site_id	AC4
Number of Residues	18
Details	binding site for residue SAM A 3004

Chain	Residue
A	LYS2150
A	TRP2152
A	SER2191
A	ASP2192
A	HIS2193
A	TYR2194
A	ARG2214
A	PHE2215
A	ILE2216
A	ASN2217
A	HIS2218
A	TYR2255
A	GLN2266
A	LEU2267
A	CYS2268
A	LYS2269
A	ILE2279
A	HOH3131

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN B 2301

Chain	Residue
B	CYS2091
B	CYS2093
B	CYS2104
B	CYS2108

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 2302

Chain	Residue
B	CYS2104
B	CYS2117
B	CYS2122
B	CYS2128

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN B 2303

Chain	Residue
B	CYS2220
B	CYS2268
B	CYS2270
B	CYS2275

---

site_id	AC8
Number of Residues	13
Details	binding site for residue SAM B 2304

Chain	Residue
B	LYS2150
B	TRP2152
B	ASP2192
B	HIS2193
B	TYR2194
B	ARG2214
B	ASN2217
B	HIS2218
B	TYR2255
B	GLN2266
B	LEU2267
B	LYS2269
B	ILE2279

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN C 2301

Chain	Residue
C	CYS2091
C	CYS2093
C	CYS2104
C	CYS2108

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN C 2302

Chain	Residue
C	CYS2104
C	CYS2117
C	CYS2122
C	CYS2128

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN C 2303

Chain	Residue
C	CYS2220
C	CYS2268
C	CYS2270
C	CYS2275

---

site_id	AD3
Number of Residues	16
Details	binding site for residue SAM C 2304

Chain	Residue
C	LYS2150
C	TRP2152
C	SER2191
C	ASP2192
C	HIS2193
C	TYR2194
C	ARG2214
C	PHE2215
C	ASN2217
C	HIS2218
C	TYR2255
C	GLN2266
C	LEU2267
C	CYS2268
C	LYS2269
C	ILE2279

---

site_id	AD4
Number of Residues	5
Details	binding site for residue ZN D 2301

Chain	Residue
D	CYS2091
D	CYS2093
D	CYS2104
D	CYS2108
D	ZN2302

---

site_id	AD5
Number of Residues	5
Details	binding site for residue ZN D 2302

Chain	Residue
D	CYS2104
D	CYS2117
D	CYS2122
D	CYS2128
D	ZN2301

---

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN D 2303

Chain	Residue
D	CYS2220
D	CYS2268
D	CYS2270
D	CYS2275

---

site_id	AD7
Number of Residues	16
Details	binding site for residue SAM D 2304

Chain	Residue
D	TRP2152
D	ASP2192
D	HIS2193
D	TYR2194
D	ARG2214
D	ASN2217
D	HIS2218
D	TYR2255
D	GLN2266
D	LEU2267
D	CYS2268
D	LYS2269
D	ILE2279
D	HOH2419
D	LYS2150
D	GLY2151

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	204
Details	Domain: {"description":"AWS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00562","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	464
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Domain: {"description":"Post-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00155","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---