4YE6
The crystal structure of the intact human GlnRS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004819 | molecular_function | glutamine-tRNA ligase activity |
| A | 0004860 | molecular_function | protein kinase inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006425 | biological_process | glutaminyl-tRNA aminoacylation |
| A | 0006469 | biological_process | negative regulation of protein kinase activity |
| A | 0007420 | biological_process | brain development |
| A | 0017101 | cellular_component | aminoacyl-tRNA synthetase multienzyme complex |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0032873 | biological_process | negative regulation of stress-activated MAPK cascade |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0043039 | biological_process | tRNA aminoacylation |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 2001234 | biological_process | negative regulation of apoptotic signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 12 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PepNGiLHIGHA |
| Chain | Residue | Details |
| A | PRO270-ALA281 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00962 |
| Chain | Residue | Details |
| A | GLU271 | |
| A | HIS277 | |
| A | ASP303 | |
| A | TYR438 | |
| A | THR457 | |
| A | ARG486 | |
| A | VAL494 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.5, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | ALA2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER70 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS309 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER495 |
