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4YDY

CRYSTAL STRUCTURE OF DARPIN 44C12V5 IN COMPLEX WITH HUMAN IL-4

Functional Information from GO Data
ChainGOidnamespacecontents
I0000122biological_processnegative regulation of transcription by RNA polymerase II
I0005125molecular_functioncytokine activity
I0005126molecular_functioncytokine receptor binding
I0005136molecular_functioninterleukin-4 receptor binding
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005615cellular_componentextracellular space
I0006955biological_processimmune response
I0007259biological_processcell surface receptor signaling pathway via JAK-STAT
I0008083molecular_functiongrowth factor activity
I0008203biological_processcholesterol metabolic process
I0008284biological_processpositive regulation of cell population proliferation
I0010628biological_processpositive regulation of gene expression
I0010633biological_processnegative regulation of epithelial cell migration
I0016239biological_processpositive regulation of macroautophagy
I0030183biological_processB cell differentiation
I0030335biological_processpositive regulation of cell migration
I0030890biological_processpositive regulation of B cell proliferation
I0032720biological_processnegative regulation of tumor necrosis factor production
I0032733biological_processpositive regulation of interleukin-10 production
I0032736biological_processpositive regulation of interleukin-13 production
I0035771biological_processinterleukin-4-mediated signaling pathway
I0042092biological_processtype 2 immune response
I0042102biological_processpositive regulation of T cell proliferation
I0042110biological_processT cell activation
I0042113biological_processB cell activation
I0042116biological_processmacrophage activation
I0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
I0043011biological_processmyeloid dendritic cell differentiation
I0043066biological_processnegative regulation of apoptotic process
I0045191biological_processregulation of isotype switching
I0045321biological_processleukocyte activation
I0045348biological_processpositive regulation of MHC class II biosynthetic process
I0045582biological_processpositive regulation of T cell differentiation
I0045671biological_processnegative regulation of osteoclast differentiation
I0045892biological_processnegative regulation of DNA-templated transcription
I0045893biological_processpositive regulation of DNA-templated transcription
I0045944biological_processpositive regulation of transcription by RNA polymerase II
I0048260biological_processpositive regulation of receptor-mediated endocytosis
I0048295biological_processpositive regulation of isotype switching to IgE isotypes
I0048304biological_processpositive regulation of isotype switching to IgG isotypes
I0050728biological_processnegative regulation of inflammatory response
I0050776biological_processregulation of immune response
I0051239biological_processregulation of multicellular organismal process
I0080090biological_processregulation of primary metabolic process
I0097028biological_processdendritic cell differentiation
I0120162biological_processpositive regulation of cold-induced thermogenesis
I0150076biological_processneuroinflammatory response
I0150079biological_processnegative regulation of neuroinflammatory response
I1900223biological_processpositive regulation of amyloid-beta clearance
I1901857biological_processpositive regulation of cellular respiration
I1902107biological_processpositive regulation of leukocyte differentiation
I1903660biological_processnegative regulation of complement-dependent cytotoxicity
I1903845biological_processnegative regulation of cellular response to transforming growth factor beta stimulus
I2000352biological_processnegative regulation of endothelial cell apoptotic process
I2000553biological_processpositive regulation of T-helper 2 cell cytokine production
I2001171biological_processpositive regulation of ATP biosynthetic process
J0000122biological_processnegative regulation of transcription by RNA polymerase II
J0005125molecular_functioncytokine activity
J0005126molecular_functioncytokine receptor binding
J0005136molecular_functioninterleukin-4 receptor binding
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005615cellular_componentextracellular space
J0006955biological_processimmune response
J0007259biological_processcell surface receptor signaling pathway via JAK-STAT
J0008083molecular_functiongrowth factor activity
J0008203biological_processcholesterol metabolic process
J0008284biological_processpositive regulation of cell population proliferation
J0010628biological_processpositive regulation of gene expression
J0010633biological_processnegative regulation of epithelial cell migration
J0016239biological_processpositive regulation of macroautophagy
J0030183biological_processB cell differentiation
J0030335biological_processpositive regulation of cell migration
J0030890biological_processpositive regulation of B cell proliferation
J0032720biological_processnegative regulation of tumor necrosis factor production
J0032733biological_processpositive regulation of interleukin-10 production
J0032736biological_processpositive regulation of interleukin-13 production
J0035771biological_processinterleukin-4-mediated signaling pathway
J0042092biological_processtype 2 immune response
J0042102biological_processpositive regulation of T cell proliferation
J0042110biological_processT cell activation
J0042113biological_processB cell activation
J0042116biological_processmacrophage activation
J0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
J0043011biological_processmyeloid dendritic cell differentiation
J0043066biological_processnegative regulation of apoptotic process
J0045191biological_processregulation of isotype switching
J0045321biological_processleukocyte activation
J0045348biological_processpositive regulation of MHC class II biosynthetic process
J0045582biological_processpositive regulation of T cell differentiation
J0045671biological_processnegative regulation of osteoclast differentiation
J0045892biological_processnegative regulation of DNA-templated transcription
J0045893biological_processpositive regulation of DNA-templated transcription
J0045944biological_processpositive regulation of transcription by RNA polymerase II
J0048260biological_processpositive regulation of receptor-mediated endocytosis
J0048295biological_processpositive regulation of isotype switching to IgE isotypes
J0048304biological_processpositive regulation of isotype switching to IgG isotypes
J0050728biological_processnegative regulation of inflammatory response
J0050776biological_processregulation of immune response
J0051239biological_processregulation of multicellular organismal process
J0080090biological_processregulation of primary metabolic process
J0097028biological_processdendritic cell differentiation
J0120162biological_processpositive regulation of cold-induced thermogenesis
J0150076biological_processneuroinflammatory response
J0150079biological_processnegative regulation of neuroinflammatory response
J1900223biological_processpositive regulation of amyloid-beta clearance
J1901857biological_processpositive regulation of cellular respiration
J1902107biological_processpositive regulation of leukocyte differentiation
J1903660biological_processnegative regulation of complement-dependent cytotoxicity
J1903845biological_processnegative regulation of cellular response to transforming growth factor beta stimulus
J2000352biological_processnegative regulation of endothelial cell apoptotic process
J2000553biological_processpositive regulation of T-helper 2 cell cytokine production
J2001171biological_processpositive regulation of ATP biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue GOL A 201
ChainResidue
AASP27
ALEU60
AGLU61
AHOH312
AHOH387
BGLY58
BHIS59
BLEU60
BGLU61

site_idAC2
Number of Residues5
Detailsbinding site for residue GOL A 202
ChainResidue
AARG31
ALYS68
AHIS69
AHOH390
JLYS61

site_idAC3
Number of Residues3
Detailsbinding site for residue ACT B 1001
ChainResidue
BARG31
BLYS68
BHIS69

Functional Information from PROSITE/UniProt
site_idPS00838
Number of Residues26
DetailsINTERLEUKIN_4_13 Interleukins -4 and -13 signature. LqEIIktlnsLTeqktl..CteltVtDI
ChainResidueDetails
ILEU7-ILE32

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"1993171","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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