4YCX

Binary complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005634	cellular_component	nucleus
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue MG A 701

Chain	Residue
A	ASP330
A	ASP332
A	ASP418
A	HOH802
A	HOH830
A	HOH839
P	HOH101

---

site_id	AC2
Number of Residues	4
Details	binding site for residue NA A 702

Chain	Residue
A	HOH1027
P	HOH103
A	HOH828
A	HOH977

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 703

Chain	Residue
A	THR194
A	THR314
A	THR336
A	PHE427
A	HOH935

---

site_id	AC4
Number of Residues	2
Details	binding site for residue GOL A 704

Chain	Residue
A	PHE469
T	DT7

---

site_id	AC5
Number of Residues	6
Details	binding site for residue IMD A 705

Chain	Residue
A	GLY433
A	TRP434
A	SER458
A	HOH889
A	HOH892
P	DA4

---

site_id	AC6
Number of Residues	2
Details	binding site for residue GOL T 101

Chain	Residue
T	DA6
T	DT7

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GGFrRGklqGhDVDFLIthP

Chain	Residue	Details
A	GLY319-PRO338

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Region: {"description":"Involved in ssDNA binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Responsible for the low discrimination between dNTP and rNTP"}

Chain

Residue

Details

---