4YAF
rat CYPOR with 2'-AMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003420 | biological_process | regulation of growth plate cartilage chondrocyte proliferation |
| A | 0003958 | molecular_function | NADPH-hemoprotein reductase activity |
| A | 0004128 | molecular_function | cytochrome-b5 reductase activity, acting on NAD(P)H |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0007584 | biological_process | response to nutrient |
| A | 0008941 | molecular_function | nitric oxide dioxygenase NAD(P)H activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009437 | biological_process | carnitine metabolic process |
| A | 0009725 | biological_process | response to hormone |
| A | 0009812 | biological_process | flavonoid metabolic process |
| A | 0010181 | molecular_function | FMN binding |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019395 | biological_process | fatty acid oxidation |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0032332 | biological_process | positive regulation of chondrocyte differentiation |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0043602 | biological_process | nitrate catabolic process |
| A | 0045542 | biological_process | positive regulation of cholesterol biosynthetic process |
| A | 0045880 | biological_process | positive regulation of smoothened signaling pathway |
| A | 0046210 | biological_process | nitric oxide catabolic process |
| A | 0047726 | molecular_function | iron-cytochrome-c reductase activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070988 | biological_process | demethylation |
| A | 0071371 | biological_process | cellular response to gonadotropin stimulus |
| A | 0071372 | biological_process | cellular response to follicle-stimulating hormone stimulus |
| A | 0071375 | biological_process | cellular response to peptide hormone stimulus |
| A | 0071548 | biological_process | response to dexamethasone |
| A | 0090031 | biological_process | positive regulation of steroid hormone biosynthetic process |
| A | 0090181 | biological_process | regulation of cholesterol metabolic process |
| A | 0090346 | biological_process | cellular organofluorine metabolic process |
| B | 0003420 | biological_process | regulation of growth plate cartilage chondrocyte proliferation |
| B | 0003958 | molecular_function | NADPH-hemoprotein reductase activity |
| B | 0004128 | molecular_function | cytochrome-b5 reductase activity, acting on NAD(P)H |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0007584 | biological_process | response to nutrient |
| B | 0008941 | molecular_function | nitric oxide dioxygenase NAD(P)H activity |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009437 | biological_process | carnitine metabolic process |
| B | 0009725 | biological_process | response to hormone |
| B | 0009812 | biological_process | flavonoid metabolic process |
| B | 0010181 | molecular_function | FMN binding |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019395 | biological_process | fatty acid oxidation |
| B | 0019899 | molecular_function | enzyme binding |
| B | 0022900 | biological_process | electron transport chain |
| B | 0032332 | biological_process | positive regulation of chondrocyte differentiation |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0043602 | biological_process | nitrate catabolic process |
| B | 0045542 | biological_process | positive regulation of cholesterol biosynthetic process |
| B | 0045880 | biological_process | positive regulation of smoothened signaling pathway |
| B | 0046210 | biological_process | nitric oxide catabolic process |
| B | 0047726 | molecular_function | iron-cytochrome-c reductase activity |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050661 | molecular_function | NADP binding |
| B | 0070988 | biological_process | demethylation |
| B | 0071371 | biological_process | cellular response to gonadotropin stimulus |
| B | 0071372 | biological_process | cellular response to follicle-stimulating hormone stimulus |
| B | 0071375 | biological_process | cellular response to peptide hormone stimulus |
| B | 0071548 | biological_process | response to dexamethasone |
| B | 0090031 | biological_process | positive regulation of steroid hormone biosynthetic process |
| B | 0090181 | biological_process | regulation of cholesterol metabolic process |
| B | 0090346 | biological_process | cellular organofluorine metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue FMN A 701 |
| Chain | Residue |
| A | SER86 |
| A | GLY141 |
| A | GLY143 |
| A | LEU173 |
| A | GLY174 |
| A | ASN175 |
| A | TYR178 |
| A | HIS180 |
| A | PHE181 |
| A | ASN182 |
| A | ASP208 |
| A | GLN87 |
| A | LEU212 |
| A | HOH918 |
| A | HOH1142 |
| A | THR88 |
| A | GLY89 |
| A | THR90 |
| A | ALA91 |
| A | ALA138 |
| A | THR139 |
| A | TYR140 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | binding site for residue FAD A 702 |
| Chain | Residue |
| A | HIS319 |
| A | ARG424 |
| A | ARG454 |
| A | TYR455 |
| A | TYR456 |
| A | SER457 |
| A | CYS472 |
| A | ALA473 |
| A | VAL474 |
| A | TYR478 |
| A | GLY488 |
| A | VAL489 |
| A | ALA490 |
| A | THR491 |
| A | TRP677 |
| A | HOH823 |
| A | HOH881 |
| A | HOH906 |
| A | HOH921 |
| A | HOH928 |
| A | HOH965 |
| A | HOH969 |
| A | HOH994 |
| A | HOH1006 |
| A | HOH1027 |
| A | HOH1085 |
| A | HOH1136 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue 2AM A 703 |
| Chain | Residue |
| A | GLY534 |
| A | CYS566 |
| A | ARG567 |
| A | SER596 |
| A | ARG597 |
| A | LYS602 |
| A | TYR604 |
| A | GLN606 |
| A | MET636 |
| A | ASP639 |
| A | HOH851 |
| A | HOH874 |
| A | HOH958 |
| A | HOH1075 |
| A | HOH1102 |
| A | HOH1108 |
| A | HOH1182 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | binding site for residue FMN B 701 |
| Chain | Residue |
| B | SER86 |
| B | GLN87 |
| B | THR88 |
| B | GLY89 |
| B | THR90 |
| B | ALA91 |
| B | ALA138 |
| B | THR139 |
| B | TYR140 |
| B | GLY141 |
| B | GLY143 |
| B | LEU173 |
| B | GLY174 |
| B | ASN175 |
| B | TYR178 |
| B | HIS180 |
| B | PHE181 |
| B | ASN182 |
| B | ASP208 |
| B | LEU212 |
| B | HOH947 |
| site_id | AC5 |
| Number of Residues | 26 |
| Details | binding site for residue FAD B 702 |
| Chain | Residue |
| B | ALA490 |
| B | THR491 |
| B | TRP677 |
| B | HOH811 |
| B | HOH856 |
| B | HOH862 |
| B | HOH868 |
| B | HOH888 |
| B | HOH893 |
| B | HOH901 |
| B | HOH950 |
| B | HOH976 |
| B | HOH1084 |
| B | HOH1099 |
| B | HIS319 |
| B | ARG424 |
| B | ARG454 |
| B | TYR455 |
| B | TYR456 |
| B | SER457 |
| B | CYS472 |
| B | ALA473 |
| B | VAL474 |
| B | TYR478 |
| B | GLY488 |
| B | VAL489 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | binding site for residue 2AM B 703 |
| Chain | Residue |
| B | CYS566 |
| B | ARG567 |
| B | SER596 |
| B | ARG597 |
| B | LYS602 |
| B | TYR604 |
| B | GLN606 |
| B | MET636 |
| B | ASP639 |
| B | HOH814 |
| B | HOH879 |
| B | HOH1024 |
| B | HOH1026 |
| B | HOH1072 |
| B | HOH1113 |
| B | HOH1145 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 B 704 |
| Chain | Residue |
| B | HIS465 |
| B | PRO466 |
| B | ASN467 |
| B | SER468 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| A | SER86 | |
| A | TRP677 | |
| B | SER86 | |
| B | ALA138 | |
| B | LEU173 | |
| B | ARG454 | |
| B | TYR478 | |
| B | GLY488 | |
| B | THR535 | |
| B | SER596 | |
| B | LYS602 | |
| A | ALA138 | |
| B | TRP677 | |
| A | LEU173 | |
| A | ARG454 | |
| A | TYR478 | |
| A | GLY488 | |
| A | THR535 | |
| A | SER596 | |
| A | LYS602 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990 |
| Chain | Residue | Details |
| A | ASP208 | |
| B | ASP208 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|PubMed:9237990 |
| Chain | Residue | Details |
| A | ARG298 | |
| A | ASP639 | |
| B | ARG298 | |
| B | ASP639 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:21345800, ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| A | ARG424 | |
| B | ARG424 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:11371558, ECO:0000269|PubMed:19171935, ECO:0000269|PubMed:9237990, ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| A | CYS472 | |
| B | CYS472 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 117 |
| Chain | Residue | Details |
| A | SER457 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay, radical stabiliser |
| A | CYS630 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay, steric role, van der waals interaction |
| A | ASP675 | hydrogen bond acceptor, modifies pKa |
| A | TRP677 | steric role |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 117 |
| Chain | Residue | Details |
| B | SER457 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay, radical stabiliser |
| B | CYS630 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay, steric role, van der waals interaction |
| B | ASP675 | hydrogen bond acceptor, modifies pKa |
| B | TRP677 | steric role |
