4Y34

Crystal Structure of Coxsackievirus B3 3D polymerase in complex with GPC-N143

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0006351	biological_process	DNA-templated transcription
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue 45Z A 501

Chain	Residue
A	LEU110
A	GLY293
A	THR294
A	SER295
A	TYR327
A	ASP111
A	THR114
A	ARG188
A	TYR195
A	HIS199
A	GLY290
A	CYS291
A	SER292

---

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 502

Chain	Residue
A	ARG174
A	GLY236

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site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 503

Chain	Residue
A	ARG416
A	PRO449
A	HOH624

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site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 504

Chain	Residue
A	GLN384
A	TYR385
A	LYS409
A	ARG455

---

site_id	AC5
Number of Residues	4
Details	binding site for residue GOL A 505

Chain	Residue
A	LYS38
A	ARG163
A	SER164
A	HOH651

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 506

Chain	Residue
A	LYS38
A	LYS376
A	ASP397
A	GOL508

---

site_id	AC7
Number of Residues	4
Details	binding site for residue GOL A 507

Chain	Residue
A	THR405
A	LYS406
A	ASP407
A	HIS414

---

site_id	AC8
Number of Residues	2
Details	binding site for residue GOL A 508

Chain	Residue
A	SER401
A	SO4506

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site_id	AC9
Number of Residues	6
Details	binding site for residue GOL A 509

Chain	Residue
A	VAL29
A	TYR385
A	LEU388
A	PRO408
A	LEU459
A	HIS463

---

site_id	AD1
Number of Residues	3
Details	binding site for residue SO4 A 510

Chain	Residue
A	GLY426
A	GLU427
A	HIS428

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