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4Y1L

Ubc9 Homodimer The Missing Link in Poly-SUMO Chain Formation

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000166molecular_functionnucleotide binding
A0000795cellular_componentsynaptonemal complex
A0001221molecular_functiontranscription coregulator binding
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005643cellular_componentnuclear pore
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006511biological_processubiquitin-dependent protein catabolic process
A0007059biological_processchromosome segregation
A0007084biological_processmitotic nuclear membrane reassembly
A0008134molecular_functiontranscription factor binding
A0016604cellular_componentnuclear body
A0016605cellular_componentPML body
A0016740molecular_functiontransferase activity
A0016925biological_processprotein sumoylation
A0019789molecular_functionSUMO transferase activity
A0019899molecular_functionenzyme binding
A0030335biological_processpositive regulation of cell migration
A0036211biological_processprotein modification process
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043398molecular_functionHLH domain binding
A0044388molecular_functionsmall protein activating enzyme binding
A0045892biological_processnegative regulation of DNA-templated transcription
A0048471cellular_componentperinuclear region of cytoplasm
A0050804biological_processmodulation of chemical synaptic transmission
A0051168biological_processnuclear export
A0051301biological_processcell division
A0061656molecular_functionSUMO conjugating enzyme activity
A0071535molecular_functionRING-like zinc finger domain binding
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098978cellular_componentglutamatergic synapse
A0099523cellular_componentpresynaptic cytosol
A0099524cellular_componentpostsynaptic cytosol
A0106068cellular_componentSUMO ligase complex
A1990234cellular_componenttransferase complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000166molecular_functionnucleotide binding
B0000795cellular_componentsynaptonemal complex
B0001221molecular_functiontranscription coregulator binding
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005643cellular_componentnuclear pore
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006511biological_processubiquitin-dependent protein catabolic process
B0007059biological_processchromosome segregation
B0007084biological_processmitotic nuclear membrane reassembly
B0008134molecular_functiontranscription factor binding
B0016604cellular_componentnuclear body
B0016605cellular_componentPML body
B0016740molecular_functiontransferase activity
B0016925biological_processprotein sumoylation
B0019789molecular_functionSUMO transferase activity
B0019899molecular_functionenzyme binding
B0030335biological_processpositive regulation of cell migration
B0036211biological_processprotein modification process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043398molecular_functionHLH domain binding
B0044388molecular_functionsmall protein activating enzyme binding
B0045892biological_processnegative regulation of DNA-templated transcription
B0048471cellular_componentperinuclear region of cytoplasm
B0050804biological_processmodulation of chemical synaptic transmission
B0051168biological_processnuclear export
B0051301biological_processcell division
B0061656molecular_functionSUMO conjugating enzyme activity
B0071535molecular_functionRING-like zinc finger domain binding
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098978cellular_componentglutamatergic synapse
B0099523cellular_componentpresynaptic cytosol
B0099524cellular_componentpostsynaptic cytosol
B0106068cellular_componentSUMO ligase complex
B1990234cellular_componenttransferase complex
C0032088biological_processnegative regulation of NF-kappaB transcription factor activity
C0033235biological_processpositive regulation of protein sumoylation
C1902073biological_processpositive regulation of hypoxia-inducible factor-1alpha signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00183
Number of Residues16
DetailsUBC_1 Ubiquitin-conjugating (UBC) active site signature. FHPNVyps.GtVCLsiL
ChainResidueDetails
APHE82-LEU97

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Glycyl thioester intermediate
ChainResidueDetails
ACYS93
BCYS93

site_idSWS_FT_FI2
Number of Residues6
DetailsSITE: Interaction with RANBP2
ChainResidueDetails
AILE4
AVAL25
ALEU57
BILE4
BVAL25
BLEU57

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Substrate binding
ChainResidueDetails
AASP100
BASP100

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
ASER2
BSER2

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS65
BLYS65

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:22509284, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER71
BSER71

site_idSWS_FT_FI7
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
ALYS18
BLYS18

site_idSWS_FT_FI8
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS101
BLYS101

site_idSWS_FT_FI9
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS48
BLYS48

site_idSWS_FT_FI10
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS49
BLYS49

237735

PDB entries from 2025-06-18

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