4Y0Z

Trypsin in complex with with BPTI mutant AMINOBUTYRIC ACID

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004175	molecular_function	endopeptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006508	biological_process	proteolysis
E	0007586	biological_process	digestion
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding
E	0097180	cellular_component	serine protease inhibitor complex
E	0097655	molecular_function	serpin family protein binding
I	0004867	molecular_function	serine-type endopeptidase inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue SO4 E 301

Chain	Residue
E	TYR59
I	LYS46
E	LYS60
E	SER61
E	HOH418
E	HOH438
E	HOH456
E	HOH547
E	HOH555
E	HOH411

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 E 302

Chain	Residue
E	LYS87
E	LYS107
E	ASN247
E	HOH402
E	HOH408
E	HOH492

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 E 303

Chain	Residue
E	PRO152
E	ASP153
E	VAL154
E	LYS156
E	HOH486

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 E 304

Chain	Residue
E	ASN95
E	THR98
E	ASN100
E	ASN101
E	HOH436

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 E 305

Chain	Residue
E	PRO173
E	GLY174
E	HOH480
E	HOH426
E	HOH423

---

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 E 306

Chain	Residue
E	ASN100
E	ASN179
E	SO4307
E	HOH401
E	HOH407

---

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 E 307

Chain	Residue
E	THR177
E	SER178
E	SO4306
E	HOH481

---

site_id	AC8
Number of Residues	6
Details	binding site for residue CA E 308

Chain	Residue
E	GLU70
E	ASN72
E	VAL75
E	GLU80
E	HOH409
E	HOH460

---

site_id	AC9
Number of Residues	3
Details	binding site for residue GOL E 309

Chain	Residue
E	TYR20
E	CYS22
E	THR26

---

site_id	AD1
Number of Residues	5
Details	binding site for residue GOL E 310

Chain	Residue
E	ASN48
E	LYS241
E	ILE244
E	HOH415
E	HOH532

---

site_id	AD2
Number of Residues	7
Details	binding site for residue SO4 I 101

Chain	Residue
I	ARG42
I	HOH242
I	HOH259
I	HOH217
I	HOH204
I	HOH247
I	HOH226

---

site_id	AD3
Number of Residues	7
Details	binding site for residue SO4 I 102

Chain	Residue
I	ARG20
I	TYR35
I	HOH210
I	HOH243
I	HOH249
I	HOH216
I	HOH267

---

site_id	AD4
Number of Residues	7
Details	binding site for residue SO4 I 103

Chain	Residue
I	PRO9
I	TYR10
I	THR11
I	GLY12
I	HOH224
I	HOH269
I	HOH257

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
E	VAL53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV

Chain	Residue	Details
E	ASP191-VAL202

---

site_id	PS00280
Number of Residues	19
Details	BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FvyGGCrakrnnFksaedC

Chain	Residue	Details
I	PHE33-CYS51

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	220
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Reactive bond for trypsin"}

Chain

Residue

Details

---