4XZ9

Transaldolase variant E60Q/F132Y from T. acidophilum in complex with DHA Schiff base and G3P

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004801	molecular_function	transaldolase activity
A	0005737	cellular_component	cytoplasm
A	0005975	biological_process	carbohydrate metabolic process
A	0006098	biological_process	pentose-phosphate shunt
A	0016740	molecular_function	transferase activity
A	0016832	molecular_function	aldehyde-lyase activity
B	0004801	molecular_function	transaldolase activity
B	0005737	cellular_component	cytoplasm
B	0005975	biological_process	carbohydrate metabolic process
B	0006098	biological_process	pentose-phosphate shunt
B	0016740	molecular_function	transferase activity
B	0016832	molecular_function	aldehyde-lyase activity
C	0004801	molecular_function	transaldolase activity
C	0005737	cellular_component	cytoplasm
C	0005975	biological_process	carbohydrate metabolic process
C	0006098	biological_process	pentose-phosphate shunt
C	0016740	molecular_function	transferase activity
C	0016832	molecular_function	aldehyde-lyase activity
D	0004801	molecular_function	transaldolase activity
D	0005737	cellular_component	cytoplasm
D	0005975	biological_process	carbohydrate metabolic process
D	0006098	biological_process	pentose-phosphate shunt
D	0016740	molecular_function	transferase activity
D	0016832	molecular_function	aldehyde-lyase activity
E	0004801	molecular_function	transaldolase activity
E	0005737	cellular_component	cytoplasm
E	0005975	biological_process	carbohydrate metabolic process
E	0006098	biological_process	pentose-phosphate shunt
E	0016740	molecular_function	transferase activity
E	0016832	molecular_function	aldehyde-lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue GOL A 301

Chain	Residue
A	ASP137
E	ARG176
E	GOL301
E	HOH408
A	ASN170
A	ILE172
A	HIS173
A	ARG176
A	HOH407
E	ASN170
E	ILE172
E	HIS173

---

site_id	AC2
Number of Residues	8
Details	binding site for residue G3P B 302

Chain	Residue
B	ASP6
B	ASN28
B	TYR132
B	ARG135
B	SER167
B	ARG169
B	PDO301
B	HOH479

---

site_id	AC3
Number of Residues	11
Details	binding site for residue GOL B 303

Chain	Residue
B	ASN170
B	HIS173
B	ARG176
B	HOH407
D	ASP137
D	ASN170
D	ILE172
D	HIS173
D	ARG176
D	GOL301
D	HOH408

---

site_id	AC4
Number of Residues	8
Details	binding site for residue ACT B 304

Chain	Residue
B	ARG169
B	ASN170
B	HOH420
B	HOH442
B	HOH509
D	ARG169
D	ASN170
D	HOH481

---

site_id	AC5
Number of Residues	9
Details	binding site for residue G3P C 302

Chain	Residue
C	ASP6
C	TYR132
C	ARG135
C	ALA166
C	SER167
C	ARG169
C	PDO301
C	HOH443
C	HOH471

---

site_id	AC6
Number of Residues	11
Details	binding site for residue GOL C 303

Chain	Residue
C	ASP137
C	ASN170
C	ASN170
C	ILE172
C	ILE172
C	HIS173
C	HIS173
C	ARG176
C	ARG176
C	HOH412
C	HOH412

---

site_id	AC7
Number of Residues	8
Details	binding site for residue ACT C 304

Chain	Residue
C	ARG169
C	ARG169
C	ASN170
C	ASN170
C	HOH414
C	HOH414
C	HOH501
C	HOH501

---

site_id	AC8
Number of Residues	12
Details	binding site for residue GOL D 301

Chain	Residue
B	ASP137
B	ASN170
B	ILE172
B	HIS173
B	ARG176
B	GOL303
B	HOH407
D	ASN170
D	ILE172
D	HIS173
D	ARG176
D	HOH408

---

site_id	AC9
Number of Residues	12
Details	binding site for residue GOL E 301

Chain	Residue
A	ASN170
A	ILE172
A	HIS173
A	ARG176
A	GOL301
A	HOH407
E	ASP137
E	ASN170
E	ILE172
E	HIS173
E	ARG176
E	HOH408

---

site_id	AD1
Number of Residues	7
Details	binding site for residue ACT E 302

Chain	Residue
A	ARG169
A	ASN170
A	HOH424
E	ARG169
E	ASN170
E	HOH420
E	HOH443

---

site_id	AD2
Number of Residues	7
Details	binding site for residue ACT E 303

Chain	Residue
E	PHE154
E	ASN155
E	ILE158
E	ILE159
E	LYS160
E	HOH433
E	ARG151

---

site_id	AD3
Number of Residues	14
Details	binding site for Di-peptide PDO B 301 and LYS B 86

Chain	Residue
B	ASP6
B	THR26
B	THR27
B	ASN28
B	VAL59
B	GLN60
B	VAL61
B	VAL84
B	VAL85
B	ILE87
B	ASN108
B	SER130
B	G3P302
B	HOH405

---

site_id	AD4
Number of Residues	14
Details	binding site for Di-peptide PDO C 301 and LYS C 86

Chain	Residue
C	ASP6
C	THR26
C	THR27
C	ASN28
C	VAL59
C	GLN60
C	VAL61
C	VAL84
C	VAL85
C	ILE87
C	ASN108
C	SER130
C	G3P302
C	HOH406

---

Functional Information from PROSITE/UniProt

site_id	PS00958
Number of Residues	18
Details	TRANSALDOLASE_2 Transaldolase active site. AvVKIPmTeDGLrAiKtL

Chain	Residue	Details
A	ALA83-LEU100

---

site_id	PS01054
Number of Residues	9
Details	TRANSALDOLASE_1 Transaldolase signature 1. GVTTNPTLI

Chain	Residue	Details
A	GLY24-ILE32

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: Schiff-base intermediate with substrate => ECO:0000250

Chain	Residue	Details
A	LYS86
B	LYS86
C	LYS86
D	LYS86
E	LYS86

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