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4XZ0

ZAP-70-tSH2:compound-A complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue 4N5 A 301
ChainResidue
ACYS117
AALA121
AMET122
AMET161
AARG175
ATYR178
ASER179
AGLN182
ALYS206

site_idAC2
Number of Residues5
Detailsbinding site for residue SO4 A 302
ChainResidue
AARG17
AARG37
AARG41
ATYR238
AHOH442

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 A 303
ChainResidue
AARG170
AARG190
AARG192

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues92
DetailsDomain: {"description":"SH2 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues91
DetailsDomain: {"description":"SH2 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues59
DetailsRegion: {"description":"Interdomain A"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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