4XYX
NanB plus Optactamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004308 | molecular_function | exo-alpha-sialidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006689 | biological_process | ganglioside catabolic process |
| A | 0009313 | biological_process | oligosaccharide catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0052794 | molecular_function | exo-alpha-(2->3)-sialidase activity |
| A | 0052795 | molecular_function | exo-alpha-(2->6)-sialidase activity |
| A | 0052796 | molecular_function | exo-alpha-(2->8)-sialidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 43Z A 701 |
| Chain | Residue |
| A | TYR250 |
| A | HIS662 |
| A | ARG676 |
| A | HOH1084 |
| A | THR251 |
| A | ASN312 |
| A | GLN494 |
| A | ILE596 |
| A | SER599 |
| A | THR657 |
| A | GLU658 |
| A | LEU659 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 702 |
| Chain | Residue |
| A | ARG129 |
| A | GLU165 |
| A | VAL166 |
| A | ARG310 |
| A | HIS680 |
| A | LEU681 |
| A | SER682 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 703 |
| Chain | Residue |
| A | GLY255 |
| A | ASP283 |
| A | ASN285 |
| A | PRO660 |
| A | TRP674 |
| A | ARG676 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 704 |
| Chain | Residue |
| A | SER238 |
| A | PRO292 |
| A | ILE293 |
| A | PHE294 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 705 |
| Chain | Residue |
| A | PHE294 |
| A | ALA295 |
| A | MET296 |
| A | TRP471 |
| A | GLN473 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 A 706 |
| Chain | Residue |
| A | VAL385 |
| A | ILE404 |
| A | ASN405 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 707 |
| Chain | Residue |
| A | ARG245 |
| A | ILE246 |
| A | ARG264 |
| A | ASP270 |
| A | ILE326 |
| A | ASP327 |
| A | GLU541 |
| A | TYR653 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 708 |
| Chain | Residue |
| A | LYS313 |
| A | ASN316 |
| A | SER317 |
| A | GLN600 |
| A | HIS662 |
| A | HOH817 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 709 |
| Chain | Residue |
| A | LEU225 |
| A | SER226 |
| A | ASN227 |
| A | PO4717 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 710 |
| Chain | Residue |
| A | LEU84 |
| A | PHE105 |
| A | GLU115 |
| A | LEU126 |
| A | LYS335 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 711 |
| Chain | Residue |
| A | ASN124 |
| A | TYR125 |
| A | LEU126 |
| A | PHE127 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 712 |
| Chain | Residue |
| A | GLY195 |
| A | GLU197 |
| A | HIS435 |
| A | ASP448 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 A 713 |
| Chain | Residue |
| A | LYS527 |
| A | LYS528 |
| A | GLU573 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 714 |
| Chain | Residue |
| A | TYR160 |
| A | GLY163 |
| A | ASP217 |
| A | VAL220 |
| A | SER221 |
| A | HOH1049 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 715 |
| Chain | Residue |
| A | TYR369 |
| A | PRO478 |
| A | PRO479 |
| A | PHE480 |
| A | TRP526 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 716 |
| Chain | Residue |
| A | ASN162 |
| A | GLY163 |
| A | LEU225 |
| A | HOH979 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 717 |
| Chain | Residue |
| A | SER221 |
| A | THR222 |
| A | ILE223 |
| A | LEU225 |
| A | PO4709 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 718 |
| Chain | Residue |
| A | LYS475 |
| A | LEU476 |
| A | GLY523 |
| A | GLN524 |
| A | TRP526 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 A 719 |
| Chain | Residue |
| A | GLY96 |
| A | LYS98 |
| A | ASN99 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP270 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU541 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR653 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG245 | |
| A | ARG557 | |
| A | ARG619 |
