4XYC
NANOMOLAR INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE 1: SYNTHESIS, BIOLOGICAL EVALUATION AND X-RAY CRYSTALLOGRAPHIC STUDIES
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004356 | molecular_function | glutamine synthetase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006542 | biological_process | glutamine biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016874 | molecular_function | ligase activity |
| A | 0019740 | biological_process | nitrogen utilization |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004356 | molecular_function | glutamine synthetase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006542 | biological_process | glutamine biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016874 | molecular_function | ligase activity |
| B | 0019740 | biological_process | nitrogen utilization |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004356 | molecular_function | glutamine synthetase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006542 | biological_process | glutamine biosynthetic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016874 | molecular_function | ligase activity |
| C | 0019740 | biological_process | nitrogen utilization |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004356 | molecular_function | glutamine synthetase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006542 | biological_process | glutamine biosynthetic process |
| D | 0016020 | cellular_component | membrane |
| D | 0016874 | molecular_function | ligase activity |
| D | 0019740 | biological_process | nitrogen utilization |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004356 | molecular_function | glutamine synthetase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006542 | biological_process | glutamine biosynthetic process |
| E | 0016020 | cellular_component | membrane |
| E | 0016874 | molecular_function | ligase activity |
| E | 0019740 | biological_process | nitrogen utilization |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004356 | molecular_function | glutamine synthetase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006542 | biological_process | glutamine biosynthetic process |
| F | 0016020 | cellular_component | membrane |
| F | 0016874 | molecular_function | ligase activity |
| F | 0019740 | biological_process | nitrogen utilization |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004356 | molecular_function | glutamine synthetase activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006542 | biological_process | glutamine biosynthetic process |
| G | 0016020 | cellular_component | membrane |
| G | 0016874 | molecular_function | ligase activity |
| G | 0019740 | biological_process | nitrogen utilization |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004356 | molecular_function | glutamine synthetase activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006542 | biological_process | glutamine biosynthetic process |
| H | 0016020 | cellular_component | membrane |
| H | 0016874 | molecular_function | ligase activity |
| H | 0019740 | biological_process | nitrogen utilization |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0003824 | molecular_function | catalytic activity |
| I | 0004356 | molecular_function | glutamine synthetase activity |
| I | 0005524 | molecular_function | ATP binding |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0006542 | biological_process | glutamine biosynthetic process |
| I | 0016020 | cellular_component | membrane |
| I | 0016874 | molecular_function | ligase activity |
| I | 0019740 | biological_process | nitrogen utilization |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0003824 | molecular_function | catalytic activity |
| J | 0004356 | molecular_function | glutamine synthetase activity |
| J | 0005524 | molecular_function | ATP binding |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0006542 | biological_process | glutamine biosynthetic process |
| J | 0016020 | cellular_component | membrane |
| J | 0016874 | molecular_function | ligase activity |
| J | 0019740 | biological_process | nitrogen utilization |
| J | 0046872 | molecular_function | metal ion binding |
| K | 0003824 | molecular_function | catalytic activity |
| K | 0004356 | molecular_function | glutamine synthetase activity |
| K | 0005524 | molecular_function | ATP binding |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0006542 | biological_process | glutamine biosynthetic process |
| K | 0016020 | cellular_component | membrane |
| K | 0016874 | molecular_function | ligase activity |
| K | 0019740 | biological_process | nitrogen utilization |
| K | 0046872 | molecular_function | metal ion binding |
| L | 0003824 | molecular_function | catalytic activity |
| L | 0004356 | molecular_function | glutamine synthetase activity |
| L | 0005524 | molecular_function | ATP binding |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0006542 | biological_process | glutamine biosynthetic process |
| L | 0016020 | cellular_component | membrane |
| L | 0016874 | molecular_function | ligase activity |
| L | 0019740 | biological_process | nitrogen utilization |
| L | 0046872 | molecular_function | metal ion binding |
| M | 0003824 | molecular_function | catalytic activity |
| M | 0004356 | molecular_function | glutamine synthetase activity |
| M | 0005524 | molecular_function | ATP binding |
| M | 0005737 | cellular_component | cytoplasm |
| M | 0006542 | biological_process | glutamine biosynthetic process |
| M | 0016020 | cellular_component | membrane |
| M | 0016874 | molecular_function | ligase activity |
| M | 0019740 | biological_process | nitrogen utilization |
| M | 0046872 | molecular_function | metal ion binding |
| N | 0003824 | molecular_function | catalytic activity |
| N | 0004356 | molecular_function | glutamine synthetase activity |
| N | 0005524 | molecular_function | ATP binding |
| N | 0005737 | cellular_component | cytoplasm |
| N | 0006542 | biological_process | glutamine biosynthetic process |
| N | 0016020 | cellular_component | membrane |
| N | 0016874 | molecular_function | ligase activity |
| N | 0019740 | biological_process | nitrogen utilization |
| N | 0046872 | molecular_function | metal ion binding |
| O | 0003824 | molecular_function | catalytic activity |
| O | 0004356 | molecular_function | glutamine synthetase activity |
| O | 0005524 | molecular_function | ATP binding |
| O | 0005737 | cellular_component | cytoplasm |
| O | 0006542 | biological_process | glutamine biosynthetic process |
| O | 0016020 | cellular_component | membrane |
| O | 0016874 | molecular_function | ligase activity |
| O | 0019740 | biological_process | nitrogen utilization |
| O | 0046872 | molecular_function | metal ion binding |
| P | 0003824 | molecular_function | catalytic activity |
| P | 0004356 | molecular_function | glutamine synthetase activity |
| P | 0005524 | molecular_function | ATP binding |
| P | 0005737 | cellular_component | cytoplasm |
| P | 0006542 | biological_process | glutamine biosynthetic process |
| P | 0016020 | cellular_component | membrane |
| P | 0016874 | molecular_function | ligase activity |
| P | 0019740 | biological_process | nitrogen utilization |
| P | 0046872 | molecular_function | metal ion binding |
| Q | 0003824 | molecular_function | catalytic activity |
| Q | 0004356 | molecular_function | glutamine synthetase activity |
| Q | 0005524 | molecular_function | ATP binding |
| Q | 0005737 | cellular_component | cytoplasm |
| Q | 0006542 | biological_process | glutamine biosynthetic process |
| Q | 0016020 | cellular_component | membrane |
| Q | 0016874 | molecular_function | ligase activity |
| Q | 0019740 | biological_process | nitrogen utilization |
| Q | 0046872 | molecular_function | metal ion binding |
| R | 0003824 | molecular_function | catalytic activity |
| R | 0004356 | molecular_function | glutamine synthetase activity |
| R | 0005524 | molecular_function | ATP binding |
| R | 0005737 | cellular_component | cytoplasm |
| R | 0006542 | biological_process | glutamine biosynthetic process |
| R | 0016020 | cellular_component | membrane |
| R | 0016874 | molecular_function | ligase activity |
| R | 0019740 | biological_process | nitrogen utilization |
| R | 0046872 | molecular_function | metal ion binding |
| S | 0003824 | molecular_function | catalytic activity |
| S | 0004356 | molecular_function | glutamine synthetase activity |
| S | 0005524 | molecular_function | ATP binding |
| S | 0005737 | cellular_component | cytoplasm |
| S | 0006542 | biological_process | glutamine biosynthetic process |
| S | 0016020 | cellular_component | membrane |
| S | 0016874 | molecular_function | ligase activity |
| S | 0019740 | biological_process | nitrogen utilization |
| S | 0046872 | molecular_function | metal ion binding |
| T | 0003824 | molecular_function | catalytic activity |
| T | 0004356 | molecular_function | glutamine synthetase activity |
| T | 0005524 | molecular_function | ATP binding |
| T | 0005737 | cellular_component | cytoplasm |
| T | 0006542 | biological_process | glutamine biosynthetic process |
| T | 0016020 | cellular_component | membrane |
| T | 0016874 | molecular_function | ligase activity |
| T | 0019740 | biological_process | nitrogen utilization |
| T | 0046872 | molecular_function | metal ion binding |
| U | 0003824 | molecular_function | catalytic activity |
| U | 0004356 | molecular_function | glutamine synthetase activity |
| U | 0005524 | molecular_function | ATP binding |
| U | 0005737 | cellular_component | cytoplasm |
| U | 0006542 | biological_process | glutamine biosynthetic process |
| U | 0016020 | cellular_component | membrane |
| U | 0016874 | molecular_function | ligase activity |
| U | 0019740 | biological_process | nitrogen utilization |
| U | 0046872 | molecular_function | metal ion binding |
| V | 0003824 | molecular_function | catalytic activity |
| V | 0004356 | molecular_function | glutamine synthetase activity |
| V | 0005524 | molecular_function | ATP binding |
| V | 0005737 | cellular_component | cytoplasm |
| V | 0006542 | biological_process | glutamine biosynthetic process |
| V | 0016020 | cellular_component | membrane |
| V | 0016874 | molecular_function | ligase activity |
| V | 0019740 | biological_process | nitrogen utilization |
| V | 0046872 | molecular_function | metal ion binding |
| W | 0003824 | molecular_function | catalytic activity |
| W | 0004356 | molecular_function | glutamine synthetase activity |
| W | 0005524 | molecular_function | ATP binding |
| W | 0005737 | cellular_component | cytoplasm |
| W | 0006542 | biological_process | glutamine biosynthetic process |
| W | 0016020 | cellular_component | membrane |
| W | 0016874 | molecular_function | ligase activity |
| W | 0019740 | biological_process | nitrogen utilization |
| W | 0046872 | molecular_function | metal ion binding |
| X | 0003824 | molecular_function | catalytic activity |
| X | 0004356 | molecular_function | glutamine synthetase activity |
| X | 0005524 | molecular_function | ATP binding |
| X | 0005737 | cellular_component | cytoplasm |
| X | 0006542 | biological_process | glutamine biosynthetic process |
| X | 0016020 | cellular_component | membrane |
| X | 0016874 | molecular_function | ligase activity |
| X | 0019740 | biological_process | nitrogen utilization |
| X | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue 2K9 A 900 |
| Chain | Residue |
| A | TYR125 |
| A | PHE228 |
| A | HIS274 |
| A | SER276 |
| A | TRP278 |
| A | LYS357 |
| A | ALA358 |
| A | ARG360 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue 2K9 B 900 |
| Chain | Residue |
| B | HIS274 |
| B | SER276 |
| B | TRP278 |
| B | LYS357 |
| B | ARG360 |
| B | PHE228 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue 2K9 C 900 |
| Chain | Residue |
| C | TYR125 |
| C | PHE228 |
| C | HIS274 |
| C | SER276 |
| C | TRP278 |
| C | LYS357 |
| C | ALA358 |
| C | ARG360 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue 2K9 D 900 |
| Chain | Residue |
| D | TYR125 |
| D | GLY127 |
| D | PHE228 |
| D | HIS274 |
| D | SER276 |
| D | TRP278 |
| D | LYS357 |
| D | ALA358 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue 2K9 E 900 |
| Chain | Residue |
| E | TYR125 |
| E | PHE228 |
| E | HIS274 |
| E | SER276 |
| E | TRP278 |
| E | LYS357 |
| E | ALA358 |
| E | ARG360 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue 2K9 F 900 |
| Chain | Residue |
| F | TYR125 |
| F | PHE228 |
| F | HIS274 |
| F | SER276 |
| F | TRP278 |
| F | ALA358 |
| F | ARG360 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue 2K9 G 900 |
| Chain | Residue |
| G | TYR125 |
| G | PHE228 |
| G | HIS274 |
| G | SER276 |
| G | TRP278 |
| G | LYS357 |
| G | ALA358 |
| G | ARG360 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue 2K9 H 900 |
| Chain | Residue |
| H | TYR125 |
| H | PHE228 |
| H | HIS274 |
| H | GLN275 |
| H | SER276 |
| H | TRP278 |
| H | LYS357 |
| H | ALA358 |
| H | ARG360 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue 2K9 I 900 |
| Chain | Residue |
| I | TYR125 |
| I | PHE228 |
| I | HIS274 |
| I | SER276 |
| I | TRP278 |
| I | LYS357 |
| I | ARG360 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue 2K9 J 900 |
| Chain | Residue |
| J | TYR125 |
| J | PHE228 |
| J | HIS274 |
| J | SER276 |
| J | TRP278 |
| J | LYS357 |
| J | ALA358 |
| J | ARG360 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue 2K9 K 900 |
| Chain | Residue |
| K | TYR125 |
| K | PHE228 |
| K | HIS274 |
| K | SER276 |
| K | TRP278 |
| K | LYS357 |
| K | ALA358 |
| K | ARG360 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue 2K9 L 900 |
| Chain | Residue |
| L | TYR125 |
| L | PHE228 |
| L | HIS274 |
| L | SER276 |
| L | TRP278 |
| L | LYS357 |
| L | ALA358 |
| L | ARG360 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue 2K9 M 900 |
| Chain | Residue |
| M | ARG360 |
| M | TYR125 |
| M | PHE228 |
| M | HIS274 |
| M | GLN275 |
| M | SER276 |
| M | TRP278 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue 2K9 N 900 |
| Chain | Residue |
| N | TYR125 |
| N | PHE228 |
| N | HIS274 |
| N | TRP278 |
| N | ALA358 |
| N | ARG360 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue 2K9 O 900 |
| Chain | Residue |
| O | TYR125 |
| O | PHE228 |
| O | HIS274 |
| O | SER276 |
| O | TRP278 |
| O | ALA358 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue 2K9 P 900 |
| Chain | Residue |
| P | TYR125 |
| P | PHE228 |
| P | HIS274 |
| P | SER276 |
| P | TRP278 |
| P | LYS357 |
| P | ALA358 |
| P | ARG360 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue 2K9 Q 900 |
| Chain | Residue |
| Q | TYR125 |
| Q | PHE228 |
| Q | SER276 |
| Q | TRP278 |
| Q | ALA358 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue 2K9 R 900 |
| Chain | Residue |
| R | TYR125 |
| R | GLY127 |
| R | PHE228 |
| R | HIS274 |
| R | SER276 |
| R | TRP278 |
| R | LYS357 |
| R | ALA358 |
| R | ARG360 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue 2K9 S 900 |
| Chain | Residue |
| S | TYR125 |
| S | PHE228 |
| S | HIS274 |
| S | SER276 |
| S | TRP278 |
| S | ALA358 |
| S | ARG360 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue 2K9 T 900 |
| Chain | Residue |
| T | TYR125 |
| T | GLY127 |
| T | PHE228 |
| T | HIS274 |
| T | SER276 |
| T | TRP278 |
| T | LYS357 |
| T | ARG360 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue 2K9 U 900 |
| Chain | Residue |
| U | TYR125 |
| U | PHE228 |
| U | HIS274 |
| U | SER276 |
| U | TRP278 |
| U | ALA358 |
| U | ARG360 |
| site_id | AE4 |
| Number of Residues | 9 |
| Details | binding site for residue 2K9 V 900 |
| Chain | Residue |
| V | TYR125 |
| V | LYS211 |
| V | PHE228 |
| V | HIS274 |
| V | SER276 |
| V | TRP278 |
| V | LYS357 |
| V | ALA358 |
| V | ARG360 |
| site_id | AE5 |
| Number of Residues | 8 |
| Details | binding site for residue 2K9 W 900 |
| Chain | Residue |
| W | TYR125 |
| W | PHE228 |
| W | HIS274 |
| W | SER276 |
| W | TRP278 |
| W | LYS357 |
| W | ALA358 |
| W | ARG360 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue 2K9 X 900 |
| Chain | Residue |
| X | TYR125 |
| X | GLY127 |
| X | PHE228 |
| X | HIS274 |
| X | SER276 |
| X | TRP278 |
| X | LYS357 |
| X | ALA358 |
| X | ARG360 |
Functional Information from PROSITE/UniProt
| site_id | PS00180 |
| Number of Residues | 19 |
| Details | GLNA_1 Glutamine synthetase signature 1. FDGSSirgfqsihESDmlL |
| Chain | Residue | Details |
| A | PHE49-LEU67 |
| site_id | PS00181 |
| Number of Residues | 16 |
| Details | GLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPLfgd..NGSGmHchqS |
| Chain | Residue | Details |
| A | LYS261-SER276 |
| site_id | PS00182 |
| Number of Residues | 13 |
| Details | GLNA_ADENYLATION Glutamine synthetase class-I adenylation site. KIepqapVDKDLY |
| Chain | Residue | Details |
| A | LYS390-TYR402 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 336 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P9WN39 |
| Chain | Residue | Details |
| A | GLU129 | |
| A | ARG325 | |
| H | GLU131 | |
| H | GLU210 | |
| H | GLU215 | |
| H | GLU223 | |
| H | TYR226 | |
| H | ASN267 | |
| H | HIS272 | |
| H | HIS274 | |
| H | ARG325 | |
| H | ARG343 | |
| A | ARG343 | |
| H | ARG348 | |
| H | GLU362 | |
| H | ARG364 | |
| I | GLU129 | |
| I | GLU131 | |
| I | GLU210 | |
| I | GLU215 | |
| I | GLU223 | |
| I | TYR226 | |
| I | ASN267 | |
| A | ARG348 | |
| I | HIS272 | |
| I | HIS274 | |
| I | ARG325 | |
| I | ARG343 | |
| I | ARG348 | |
| I | GLU362 | |
| I | ARG364 | |
| J | GLU129 | |
| J | GLU131 | |
| J | GLU210 | |
| A | GLU362 | |
| J | GLU215 | |
| J | GLU223 | |
| J | TYR226 | |
| J | ASN267 | |
| J | HIS272 | |
| J | HIS274 | |
| J | ARG325 | |
| J | ARG343 | |
| J | ARG348 | |
| J | GLU362 | |
| A | ARG364 | |
| J | ARG364 | |
| K | GLU129 | |
| K | GLU131 | |
| K | GLU210 | |
| K | GLU215 | |
| K | GLU223 | |
| K | TYR226 | |
| K | ASN267 | |
| K | HIS272 | |
| K | HIS274 | |
| B | GLU129 | |
| K | ARG325 | |
| K | ARG343 | |
| K | ARG348 | |
| K | GLU362 | |
| K | ARG364 | |
| L | GLU129 | |
| L | GLU131 | |
| L | GLU210 | |
| L | GLU215 | |
| L | GLU223 | |
| B | GLU131 | |
| L | TYR226 | |
| L | ASN267 | |
| L | HIS272 | |
| L | HIS274 | |
| L | ARG325 | |
| L | ARG343 | |
| L | ARG348 | |
| L | GLU362 | |
| L | ARG364 | |
| M | GLU129 | |
| B | GLU210 | |
| M | GLU131 | |
| M | GLU210 | |
| M | GLU215 | |
| M | GLU223 | |
| M | TYR226 | |
| M | ASN267 | |
| M | HIS272 | |
| M | HIS274 | |
| M | ARG325 | |
| M | ARG343 | |
| B | GLU215 | |
| M | ARG348 | |
| M | GLU362 | |
| M | ARG364 | |
| N | GLU129 | |
| N | GLU131 | |
| N | GLU210 | |
| N | GLU215 | |
| N | GLU223 | |
| N | TYR226 | |
| N | ASN267 | |
| B | GLU223 | |
| N | HIS272 | |
| N | HIS274 | |
| N | ARG325 | |
| N | ARG343 | |
| N | ARG348 | |
| N | GLU362 | |
| N | ARG364 | |
| O | GLU129 | |
| O | GLU131 | |
| O | GLU210 | |
| A | GLU131 | |
| B | TYR226 | |
| O | GLU215 | |
| O | GLU223 | |
| O | TYR226 | |
| O | ASN267 | |
| O | HIS272 | |
| O | HIS274 | |
| O | ARG325 | |
| O | ARG343 | |
| O | ARG348 | |
| O | GLU362 | |
| B | ASN267 | |
| O | ARG364 | |
| P | GLU129 | |
| P | GLU131 | |
| P | GLU210 | |
| P | GLU215 | |
| P | GLU223 | |
| P | TYR226 | |
| P | ASN267 | |
| P | HIS272 | |
| P | HIS274 | |
| B | HIS272 | |
| P | ARG325 | |
| P | ARG343 | |
| P | ARG348 | |
| P | GLU362 | |
| P | ARG364 | |
| Q | GLU129 | |
| Q | GLU131 | |
| Q | GLU210 | |
| Q | GLU215 | |
| Q | GLU223 | |
| B | HIS274 | |
| Q | TYR226 | |
| Q | ASN267 | |
| Q | HIS272 | |
| Q | HIS274 | |
| Q | ARG325 | |
| Q | ARG343 | |
| Q | ARG348 | |
| Q | GLU362 | |
| Q | ARG364 | |
| R | GLU129 | |
| B | ARG325 | |
| R | GLU131 | |
| R | GLU210 | |
| R | GLU215 | |
| R | GLU223 | |
| R | TYR226 | |
| R | ASN267 | |
| R | HIS272 | |
| R | HIS274 | |
| R | ARG325 | |
| R | ARG343 | |
| B | ARG343 | |
| R | ARG348 | |
| R | GLU362 | |
| R | ARG364 | |
| S | GLU129 | |
| S | GLU131 | |
| S | GLU210 | |
| S | GLU215 | |
| S | GLU223 | |
| S | TYR226 | |
| S | ASN267 | |
| B | ARG348 | |
| S | HIS272 | |
| S | HIS274 | |
| S | ARG325 | |
| S | ARG343 | |
| S | ARG348 | |
| S | GLU362 | |
| S | ARG364 | |
| T | GLU129 | |
| T | GLU131 | |
| T | GLU210 | |
| B | GLU362 | |
| T | GLU215 | |
| T | GLU223 | |
| T | TYR226 | |
| T | ASN267 | |
| T | HIS272 | |
| T | HIS274 | |
| T | ARG325 | |
| T | ARG343 | |
| T | ARG348 | |
| T | GLU362 | |
| B | ARG364 | |
| T | ARG364 | |
| U | GLU129 | |
| U | GLU131 | |
| U | GLU210 | |
| U | GLU215 | |
| U | GLU223 | |
| U | TYR226 | |
| U | ASN267 | |
| U | HIS272 | |
| U | HIS274 | |
| C | GLU129 | |
| U | ARG325 | |
| U | ARG343 | |
| U | ARG348 | |
| U | GLU362 | |
| U | ARG364 | |
| V | GLU129 | |
| V | GLU131 | |
| V | GLU210 | |
| V | GLU215 | |
| V | GLU223 | |
| A | GLU210 | |
| C | GLU131 | |
| V | TYR226 | |
| V | ASN267 | |
| V | HIS272 | |
| V | HIS274 | |
| V | ARG325 | |
| V | ARG343 | |
| V | ARG348 | |
| V | GLU362 | |
| V | ARG364 | |
| W | GLU129 | |
| C | GLU210 | |
| W | GLU131 | |
| W | GLU210 | |
| W | GLU215 | |
| W | GLU223 | |
| W | TYR226 | |
| W | ASN267 | |
| W | HIS272 | |
| W | HIS274 | |
| W | ARG325 | |
| W | ARG343 | |
| C | GLU215 | |
| W | ARG348 | |
| W | GLU362 | |
| W | ARG364 | |
| X | GLU129 | |
| X | GLU131 | |
| X | GLU210 | |
| X | GLU215 | |
| X | GLU223 | |
| X | TYR226 | |
| X | ASN267 | |
| C | GLU223 | |
| X | HIS272 | |
| X | HIS274 | |
| X | ARG325 | |
| X | ARG343 | |
| X | ARG348 | |
| X | GLU362 | |
| X | ARG364 | |
| C | TYR226 | |
| C | ASN267 | |
| C | HIS272 | |
| C | HIS274 | |
| C | ARG325 | |
| C | ARG343 | |
| A | GLU215 | |
| C | ARG348 | |
| C | GLU362 | |
| C | ARG364 | |
| D | GLU129 | |
| D | GLU131 | |
| D | GLU210 | |
| D | GLU215 | |
| D | GLU223 | |
| D | TYR226 | |
| D | ASN267 | |
| A | GLU223 | |
| D | HIS272 | |
| D | HIS274 | |
| D | ARG325 | |
| D | ARG343 | |
| D | ARG348 | |
| D | GLU362 | |
| D | ARG364 | |
| E | GLU129 | |
| E | GLU131 | |
| E | GLU210 | |
| A | TYR226 | |
| E | GLU215 | |
| E | GLU223 | |
| E | TYR226 | |
| E | ASN267 | |
| E | HIS272 | |
| E | HIS274 | |
| E | ARG325 | |
| E | ARG343 | |
| E | ARG348 | |
| E | GLU362 | |
| A | ASN267 | |
| E | ARG364 | |
| F | GLU129 | |
| F | GLU131 | |
| F | GLU210 | |
| F | GLU215 | |
| F | GLU223 | |
| F | TYR226 | |
| F | ASN267 | |
| F | HIS272 | |
| F | HIS274 | |
| A | HIS272 | |
| F | ARG325 | |
| F | ARG343 | |
| F | ARG348 | |
| F | GLU362 | |
| F | ARG364 | |
| G | GLU129 | |
| G | GLU131 | |
| G | GLU210 | |
| G | GLU215 | |
| G | GLU223 | |
| A | HIS274 | |
| G | TYR226 | |
| G | ASN267 | |
| G | HIS272 | |
| G | HIS274 | |
| G | ARG325 | |
| G | ARG343 | |
| G | ARG348 | |
| G | GLU362 | |
| G | ARG364 | |
| H | GLU129 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P12425 |
| Chain | Residue | Details |
| A | GLY268 | |
| J | GLY268 | |
| K | GLY268 | |
| L | GLY268 | |
| M | GLY268 | |
| N | GLY268 | |
| O | GLY268 | |
| P | GLY268 | |
| Q | GLY268 | |
| R | GLY268 | |
| S | GLY268 | |
| B | GLY268 | |
| T | GLY268 | |
| U | GLY268 | |
| V | GLY268 | |
| W | GLY268 | |
| X | GLY268 | |
| C | GLY268 | |
| D | GLY268 | |
| E | GLY268 | |
| F | GLY268 | |
| G | GLY268 | |
| H | GLY268 | |
| I | GLY268 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P77961 |
| Chain | Residue | Details |
| A | SER276 | |
| E | LYS357 | |
| F | SER276 | |
| F | LYS357 | |
| G | SER276 | |
| G | LYS357 | |
| H | SER276 | |
| H | LYS357 | |
| I | SER276 | |
| I | LYS357 | |
| J | SER276 | |
| A | LYS357 | |
| J | LYS357 | |
| K | SER276 | |
| K | LYS357 | |
| L | SER276 | |
| L | LYS357 | |
| M | SER276 | |
| M | LYS357 | |
| N | SER276 | |
| N | LYS357 | |
| O | SER276 | |
| B | SER276 | |
| O | LYS357 | |
| P | SER276 | |
| P | LYS357 | |
| Q | SER276 | |
| Q | LYS357 | |
| R | SER276 | |
| R | LYS357 | |
| S | SER276 | |
| S | LYS357 | |
| T | SER276 | |
| B | LYS357 | |
| T | LYS357 | |
| U | SER276 | |
| U | LYS357 | |
| V | SER276 | |
| V | LYS357 | |
| W | SER276 | |
| W | LYS357 | |
| X | SER276 | |
| X | LYS357 | |
| C | SER276 | |
| C | LYS357 | |
| D | SER276 | |
| D | LYS357 | |
| E | SER276 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0A1P6 |
| Chain | Residue | Details |
| A | GLU331 | |
| J | GLU331 | |
| K | GLU331 | |
| L | GLU331 | |
| M | GLU331 | |
| N | GLU331 | |
| O | GLU331 | |
| P | GLU331 | |
| Q | GLU331 | |
| R | GLU331 | |
| S | GLU331 | |
| B | GLU331 | |
| T | GLU331 | |
| U | GLU331 | |
| V | GLU331 | |
| W | GLU331 | |
| X | GLU331 | |
| C | GLU331 | |
| D | GLU331 | |
| E | GLU331 | |
| F | GLU331 | |
| G | GLU331 | |
| H | GLU331 | |
| I | GLU331 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | MOD_RES: O-AMP-tyrosine => ECO:0000250|UniProtKB:P9WN39 |
| Chain | Residue | Details |
| A | TYR402 | |
| J | TYR402 | |
| K | TYR402 | |
| L | TYR402 | |
| M | TYR402 | |
| N | TYR402 | |
| O | TYR402 | |
| P | TYR402 | |
| Q | TYR402 | |
| R | TYR402 | |
| S | TYR402 | |
| B | TYR402 | |
| T | TYR402 | |
| U | TYR402 | |
| V | TYR402 | |
| W | TYR402 | |
| X | TYR402 | |
| C | TYR402 | |
| D | TYR402 | |
| E | TYR402 | |
| F | TYR402 | |
| G | TYR402 | |
| H | TYR402 | |
| I | TYR402 |
