Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4XXJ

Crystal Structure of Escherichia coli-Expressed Halobacterium salinarum Bacteriorhodopsin in the Trimeric Form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0007602	biological_process	phototransduction
A	0009881	molecular_function	photoreceptor activity
A	0015454	molecular_function	light-driven active monoatomic ion transmembrane transporter activity
A	0016020	cellular_component	membrane
A	1902600	biological_process	proton transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0007602	biological_process	phototransduction
B	0009881	molecular_function	photoreceptor activity
B	0015454	molecular_function	light-driven active monoatomic ion transmembrane transporter activity
B	0016020	cellular_component	membrane
B	1902600	biological_process	proton transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0007602	biological_process	phototransduction
C	0009881	molecular_function	photoreceptor activity
C	0015454	molecular_function	light-driven active monoatomic ion transmembrane transporter activity
C	0016020	cellular_component	membrane
C	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue LFA A 301

Chain	Residue
A	TRP80

site_id	AC2
Number of Residues	1
Details	binding site for residue LFA A 302

Chain	Residue
A	TYR64

site_id	AC3
Number of Residues	4
Details	binding site for residue LFA A 303

Chain	Residue
A	LEU109
A	GLY120
C	ILE52
C	MET56

site_id	AC4
Number of Residues	2
Details	binding site for residue LFA A 304

Chain	Residue
A	MET56
B	GLY116

site_id	AC5
Number of Residues	1
Details	binding site for residue LFA A 306

Chain	Residue
A	PHE135

site_id	AC6
Number of Residues	1
Details	binding site for residue LFA A 308

Chain	Residue
A	ILE4

site_id	AC7
Number of Residues	1
Details	binding site for residue LFA A 310

Chain	Residue
A	ILE198

site_id	AC8
Number of Residues	1
Details	binding site for residue LFA A 311

Chain	Residue
A	ASN176

site_id	AC9
Number of Residues	1
Details	binding site for residue LFA A 312

Chain	Residue
A	ASN176

site_id	AD1
Number of Residues	1
Details	binding site for residue LFA A 313

Chain	Residue
A	GLY23

site_id	AD2
Number of Residues	5
Details	binding site for residue MPG A 314

Chain	Residue
A	THR107
A	TYR147
C	LYS40
C	ALA44
C	PHE54

site_id	AD3
Number of Residues	1
Details	binding site for residue LFA B 301

Chain	Residue
B	TRP80

site_id	AD4
Number of Residues	1
Details	binding site for residue LFA B 302

Chain	Residue
C	LFA301

site_id	AD5
Number of Residues	1
Details	binding site for residue LFA B 307

Chain	Residue
B	VAL217

site_id	AD6
Number of Residues	2
Details	binding site for residue LFA B 308

Chain	Residue
A	PHE154
B	ASN176

site_id	AD7
Number of Residues	8
Details	binding site for residue MPG B 309

Chain	Residue
A	LYS40
A	ALA44
A	THR47
B	GLY106
B	THR107
B	ALA110
B	ILE140
B	TYR147

site_id	AD8
Number of Residues	2
Details	binding site for residue LFA C 301

Chain	Residue
B	LFA302
C	TYR64

site_id	AD9
Number of Residues	5
Details	binding site for residue LFA C 303

Chain	Residue
B	THR55
C	LEU109
C	GLY116
C	GLY120
C	THR121

site_id	AE1
Number of Residues	1
Details	binding site for residue LFA C 307

Chain	Residue
C	PHE135

site_id	AE2
Number of Residues	2
Details	binding site for residue LFA C 308

Chain	Residue
C	TYR131
C	PHE135

site_id	AE3
Number of Residues	1
Details	binding site for residue LFA C 309

Chain	Residue
C	LFA310

site_id	AE4
Number of Residues	3
Details	binding site for residue LFA C 310

Chain	Residue
B	PHE135
C	ILE203
C	LFA309

site_id	AE5
Number of Residues	3
Details	binding site for residue LFA C 311

Chain	Residue
A	VAL29
C	TYR26
C	VAL217

site_id	AE6
Number of Residues	2
Details	binding site for residue LFA C 312

Chain	Residue
C	ASN176
C	VAL177

site_id	AE7
Number of Residues	10
Details	binding site for residue MPG C 313

Chain	Residue
B	LYS40
B	ALA44
B	LEU48
B	PHE54
C	GLY106
C	THR107
C	ALA114
C	ILE117
C	ALA144
C	TYR147

Functional Information from PROSITE/UniProt

site_id	PS00327
Number of Residues	12
Details	BACTERIAL_OPSIN_RET Bacterial rhodopsins retinal binding site. FMVLDVsAKvGF

Chain	Residue	Details
A	PHE208-PHE219

site_id	PS00950
Number of Residues	13
Details	BACTERIAL_OPSIN_1 Bacterial rhodopsins signature 1. RYaDWlFTTPLLL

Chain	Residue	Details
A	ARG82-LEU94

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=Helix A","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	103
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=Helix B","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	99
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=Helix C","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=Helix D","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=Helix E","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=Helix F","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	3
Details	Site: {"description":"Primary proton acceptor","evidences":[{"source":"PubMed","id":"10903866","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"10949309","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	3
Details	Modified residue: {"description":"N6-(retinylidene)lysine","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10467143","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10548112","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10903866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10949307","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10949309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11829498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6794028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9287223","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9632391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9751724","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1F50","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KG9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O0A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q5J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QHJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QM8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R84","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TN5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UCQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1X0I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1X0K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1X0S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XJI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BRD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I20","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I21","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WJK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WJL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZFE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZZL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3COD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HAP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HAR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NSB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T45","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VI0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FPD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MD1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MD2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X31","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X32","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5A44","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5A45","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5B34","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5B6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5B6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5B6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5B6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5B6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BR5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J7A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)