4XXB
Crystal structure of human MDM2-RPL11
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000027 | biological_process | ribosomal large subunit assembly |
| A | 0002181 | biological_process | cytoplasmic translation |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003735 | molecular_function | structural constituent of ribosome |
| A | 0005515 | molecular_function | protein binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005840 | cellular_component | ribosome |
| A | 0006364 | biological_process | rRNA processing |
| A | 0006412 | biological_process | translation |
| A | 0006605 | biological_process | protein targeting |
| A | 0006941 | biological_process | striated muscle contraction |
| A | 0007283 | biological_process | spermatogenesis |
| A | 0008097 | molecular_function | 5S rRNA binding |
| A | 0016020 | cellular_component | membrane |
| A | 0019843 | molecular_function | rRNA binding |
| A | 0022625 | cellular_component | cytosolic large ribosomal subunit |
| A | 0022626 | cellular_component | cytosolic ribosome |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0032435 | biological_process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034504 | biological_process | protein localization to nucleus |
| A | 0042273 | biological_process | ribosomal large subunit biogenesis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1901740 | biological_process | negative regulation of myoblast fusion |
| A | 1901796 | biological_process | regulation of signal transduction by p53 class mediator |
| A | 1901798 | biological_process | positive regulation of signal transduction by p53 class mediator |
| A | 1990904 | cellular_component | ribonucleoprotein complex |
| A | 1990948 | molecular_function | ubiquitin ligase inhibitor activity |
| A | 2000059 | biological_process | negative regulation of ubiquitin-dependent protein catabolic process |
| B | 0005634 | cellular_component | nucleus |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue IMD A 201 |
| Chain | Residue |
| A | CYS25 |
| A | ILE68 |
| A | ALA69 |
| A | ZN203 |
| B | PRO316 |
| B | HIS318 |
| B | ASN320 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue BME A 202 |
| Chain | Residue |
| B | ASP294 |
| B | PRO314 |
| B | LEU315 |
| A | CYS21 |
| A | TYR131 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 203 |
| Chain | Residue |
| A | CYS25 |
| A | IMD201 |
| A | HOH322 |
| B | HIS318 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | CYS305 |
| B | CYS308 |
| B | CYS319 |
| B | CYS322 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 29 |
| Details | Zinc finger: {"description":"RanBP2-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00322","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37291423","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8BGU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
