4XR5

X-ray structure of the unliganded thymidine phosphorylase from Salmonella typhimurium at 2.05 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004645	molecular_function	1,4-alpha-oligoglucan phosphorylase activity
A	0005829	cellular_component	cytosol
A	0006206	biological_process	pyrimidine nucleobase metabolic process
A	0006213	biological_process	pyrimidine nucleoside metabolic process
A	0009032	molecular_function	thymidine phosphorylase activity
A	0016154	molecular_function	pyrimidine-nucleoside phosphorylase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0046104	biological_process	thymidine metabolic process
B	0004645	molecular_function	1,4-alpha-oligoglucan phosphorylase activity
B	0005829	cellular_component	cytosol
B	0006206	biological_process	pyrimidine nucleobase metabolic process
B	0006213	biological_process	pyrimidine nucleoside metabolic process
B	0009032	molecular_function	thymidine phosphorylase activity
B	0016154	molecular_function	pyrimidine-nucleoside phosphorylase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0046104	biological_process	thymidine metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue PGE A 501

Chain	Residue
A	HIS15
A	LYS332
A	TYR333

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site_id	AC2
Number of Residues	5
Details	binding site for residue PGE A 502

Chain	Residue
A	SER249
A	ARG257
A	GLU258
A	GLN261
A	ASP385

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site_id	AC3
Number of Residues	1
Details	binding site for residue CL B 501

Chain	Residue
B	ARG268

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site_id	AC4
Number of Residues	2
Details	binding site for residue PEG B 502

Chain	Residue
B	ASP71
B	SER74

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site_id	AC5
Number of Residues	3
Details	binding site for residue PGE B 503

Chain	Residue
B	LYS332
B	LEU334
B	THR336

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Functional Information from PROSITE/UniProt

site_id	PS00647
Number of Residues	16
Details	THYMID_PHOSPHORYLASE Thymidine and pyrimidine-nucleoside phosphorylases signature. SGRGLghTGGTlDkLE

Chain	Residue	Details
A	SER113-GLU128

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