4XPF
X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to RTI-55
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue DMU A 701 |
| Chain | Residue |
| A | ARG133 |
| A | PHE136 |
| A | TYR219 |
| A | ASP238 |
| L | ARG156 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue 42F A 703 |
| Chain | Residue |
| A | TYR123 |
| A | TYR124 |
| A | ASN125 |
| A | SER422 |
| A | GLY425 |
| A | PHE43 |
| A | ASP46 |
| A | VAL120 |
| A | GLY121 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CLR A 704 |
| Chain | Residue |
| A | PHE350 |
| A | TRP519 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CLR A 705 |
| Chain | Residue |
| A | TYR273 |
| A | LEU277 |
| A | ILE351 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 706 |
| Chain | Residue |
| A | ALA44 |
| A | ASP46 |
| A | ASN49 |
| A | SER320 |
| A | ASN352 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 707 |
| Chain | Residue |
| A | GLY42 |
| A | VAL45 |
| A | LEU417 |
| A | ASP420 |
| A | SER421 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 708 |
| Chain | Residue |
| A | TYR69 |
| A | GLN316 |
| A | SER320 |
| A | SER356 |
Functional Information from PROSITE/UniProt
| site_id | PS00610 |
| Number of Residues | 15 |
| Details | NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcykNGGGaF |
| Chain | Residue | Details |
| A | TRP51-PHE65 |
| site_id | PS00754 |
| Number of Residues | 21 |
| Details | NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. FFfaSFTnsLPWtsCnniwNT |
| Chain | Residue | Details |
| A | PHE134-THR154 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR193-HIS199 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245 |
| Chain | Residue | Details |
| A | VAL34-LYS59 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 164 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245 |
| Chain | Residue | Details |
| A | ASN60-GLY63 | |
| A | PHE139-ILE278 | |
| A | LEU328-ILE351 | |
| A | LEU408-PHE447 | |
| A | MET510 | |
| A | THR591-LEU593 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245 |
| Chain | Residue | Details |
| A | ALA64-LEU87 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 69 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245 |
| Chain | Residue | Details |
| A | GLY88-LYS107 | |
| A | ASN300-SER302 | |
| A | ILE378-THR383 | |
| A | LEU474-PHE488 | |
| A | GLY538-SER567 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 30 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245 |
| Chain | Residue | Details |
| A | GLY108-SER138 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245 |
| Chain | Residue | Details |
| A | LEU279-PRO299 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25961798, ECO:0000269|PubMed:25970245 |
| Chain | Residue | Details |
| A | ALA303-VAL327 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245 |
| Chain | Residue | Details |
| A | ASN352-ARG377 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245 |
| Chain | Residue | Details |
| A | GLU384-ALA407 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245 |
| Chain | Residue | Details |
| A | VAL448-LEU473 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245 |
| Chain | Residue | Details |
| A | PHE489-ASP509 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245 |
| Chain | Residue | Details |
| A | ILE511-TYR537 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245 |
| Chain | Residue | Details |
| A | VAL568-PHE590 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24037379, ECO:0000269|PubMed:25970245, ECO:0007744|PDB:4XP1 |
| Chain | Residue | Details |
| A | GLY42 | |
| A | ALA44 | |
| A | VAL45 | |
| A | ASN49 | |
| A | ILE363 | |
| A | ALA395 | |
| A | LEU460 | |
| A | CYS463 | |
| A | THR464 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0007744|PDB:4XP1 |
| Chain | Residue | Details |
| A | ASP46 | |
| A | ALA117 | |
| A | GLY121 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; atypical => ECO:0000269|PubMed:25970245, ECO:0007744|PDB:4XP1 |
| Chain | Residue | Details |
| A | ASN141 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 7 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | GLY207 | |
| A | PHE216 | |
| A | ARG225 | |
| A | ASP231 | |
| A | LYS236 | |
| A | PHE267 | |
| A | LYS343 |
