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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4XND

Crystal Structure of E. coli Aminopeptidase N in complex with L-Beta Homotryptophan

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 901

Chain	Residue
A	HIS297
A	HIS301
A	GLU320
A	HT7902

site_id	AC2
Number of Residues	16
Details	binding site for residue HT7 A 902

Chain	Residue
A	GLU264
A	HIS297
A	GLU298
A	HIS301
A	LYS319
A	GLU320
A	ASN373
A	TYR381
A	ZN901
A	MLI941
A	HOH1501
A	GLN119
A	GLU121
A	MET260
A	ALA262
A	MET263

site_id	AC3
Number of Residues	5
Details	binding site for residue NA A 903

Chain	Residue
A	GLN19
A	ILE20
A	LEU138
A	HOH1549
A	HOH1753

site_id	AC4
Number of Residues	5
Details	binding site for residue NA A 904

Chain	Residue
A	ASP452
A	GOL932
A	MLI946
A	HOH1001
A	HOH1664

site_id	AC5
Number of Residues	6
Details	binding site for residue NA A 905

Chain	Residue
A	ASN399
A	SER429
A	HOH1419
A	HOH1552
A	HOH1665
A	HOH1694

site_id	AC6
Number of Residues	6
Details	binding site for residue NA A 906

Chain	Residue
A	ASN344
A	GLU382
A	HOH1079
A	HOH1161
A	HOH1339
A	HOH1344

site_id	AC7
Number of Residues	6
Details	binding site for residue NA A 907

Chain	Residue
A	SER332
A	ASP333
A	GLY335
A	MLI936
A	HOH1177
A	HOH1648

site_id	AC8
Number of Residues	5
Details	binding site for residue NA A 908

Chain	Residue
A	GLY350
A	ASN623
A	HOH1028
A	HOH1223
A	HOH1645

site_id	AC9
Number of Residues	5
Details	binding site for residue NA A 909

Chain	Residue
A	ASN67
A	THR91
A	HOH1710
A	HOH1724
A	HOH1745

site_id	AD1
Number of Residues	7
Details	binding site for residue NA A 910

Chain	Residue
A	LEU551
A	SER570
A	THR574
A	GOL921
A	HOH1328
A	HOH1390
A	HOH1469

site_id	AD2
Number of Residues	7
Details	binding site for residue GOL A 911

Chain	Residue
A	ALA531
A	LEU532
A	TRP546
A	SER563
A	ASP566
A	ALA567
A	SER570

site_id	AD3
Number of Residues	9
Details	binding site for residue GOL A 912

Chain	Residue
A	LYS8
A	GLU123
A	ASP312
A	TRP313
A	PHE314
A	HOH1057
A	HOH1334
A	HOH1395
A	HOH1568

site_id	AD4
Number of Residues	6
Details	binding site for residue GOL A 913

Chain	Residue
A	THR72
A	TRP74
A	VAL670
A	GLU671
A	GOL915
A	HOH1502

site_id	AD5
Number of Residues	9
Details	binding site for residue GOL A 914

Chain	Residue
A	GLU69
A	PRO70
A	TRP71
A	THR72
A	ASP221
A	PRO224
A	ALA278
A	TYR288
A	HOH1077

site_id	AD6
Number of Residues	10
Details	binding site for residue GOL A 915

Chain	Residue
A	TRP74
A	ARG669
A	VAL670
A	GLU671
A	GOL913
A	MLI934
A	HOH1347
A	SER63
A	VAL64
A	TRP71

site_id	AD7
Number of Residues	5
Details	binding site for residue GOL A 916

Chain	Residue
A	ASN623
A	GLY791
A	MLI933
A	HOH1198
A	HOH1243

site_id	AD8
Number of Residues	5
Details	binding site for residue GOL A 917

Chain	Residue
A	GLU292
A	VAL670
A	HIS672
A	HOH1014
A	HOH1502

site_id	AD9
Number of Residues	8
Details	binding site for residue GOL A 918

Chain	Residue
A	ARG681
A	GLN703
A	ALA707
A	ASN708
A	ASN709
A	ASP712
A	HOH1069
A	HOH1521

site_id	AE1
Number of Residues	6
Details	binding site for residue GOL A 919

Chain	Residue
A	THR755
A	PRO757
A	SER792
A	ASN793
A	HOH1119
A	HOH1433

site_id	AE2
Number of Residues	8
Details	binding site for residue GOL A 920

Chain	Residue
A	MET260
A	GLY261
A	LYS274
A	TYR275
A	ARG783
A	ARG825
A	MLI941
A	MLI942

site_id	AE3
Number of Residues	11
Details	binding site for residue GOL A 921

Chain	Residue
A	ARG207
A	GLU208
A	ASP248
A	LYS545
A	TRP546
A	THR574
A	NA910
A	HOH1007
A	HOH1091
A	HOH1390
A	HOH1469

site_id	AE4
Number of Residues	5
Details	binding site for residue GOL A 922

Chain	Residue
A	VAL162
A	GLN177
A	GLN549
A	HOH1009
A	HOH1035

site_id	AE5
Number of Residues	3
Details	binding site for residue GOL A 923

Chain	Residue
A	LYS144
A	GLN175
A	ASN492

site_id	AE6
Number of Residues	7
Details	binding site for residue GOL A 924

Chain	Residue
A	SER441
A	GLN442
A	GLU477
A	GLN479
A	HOH1181
A	HOH1181
A	HOH1374

site_id	AE7
Number of Residues	5
Details	binding site for residue GOL A 925

Chain	Residue
A	ASN232
A	TRP236
A	GLU239
A	HOH1014
A	HOH1059

site_id	AE8
Number of Residues	11
Details	binding site for residue GOL A 926

Chain	Residue
A	GLU244
A	TYR245
A	ASP246
A	TRP303
A	ARG307
A	LEU578
A	SER590
A	LEU591
A	PRO592
A	HOH1179
A	HOH1300

site_id	AE9
Number of Residues	10
Details	binding site for residue GOL A 927

Chain	Residue
A	LEU617
A	THR618
A	LEU619
A	ARG641
A	THR645
A	ALA683
A	ARG686
A	PHE687
A	MLI939
A	HOH1173

site_id	AF1
Number of Residues	8
Details	binding site for residue GOL A 928

Chain	Residue
A	LEU289
A	ASN343
A	GLU615
A	ILE675
A	THR679
A	HOH1027
A	HOH1155
A	HOH1584

site_id	AF2
Number of Residues	7
Details	binding site for residue GOL A 929

Chain	Residue
A	PRO16
A	ASP17
A	TYR18
A	ARG53
A	ARG134
A	HOH1056
A	HOH1093

site_id	AF3
Number of Residues	8
Details	binding site for residue GOL A 930

Chain	Residue
A	ASN160
A	ASP246
A	LEU247
A	ASP248
A	SER547
A	ASP548
A	GLN549
A	HOH1091

site_id	AF4
Number of Residues	5
Details	binding site for residue GOL A 931

Chain	Residue
A	ASP68
A	GLU69
A	THR280
A	ASP281
A	ASN708

site_id	AF5
Number of Residues	10
Details	binding site for residue GOL A 932

Chain	Residue
A	ASP452
A	TYR461
A	GLN527
A	PRO528
A	TYR544
A	GLN550
A	NA904
A	MLI946
A	HOH1064
A	HOH1688

site_id	AF6
Number of Residues	9
Details	binding site for residue MLI A 933

Chain	Residue
A	ALA354
A	ILE632
A	ARG832
A	ARG835
A	TYR836
A	GOL916
A	HOH1028
A	HOH1120
A	HOH1261

site_id	AF7
Number of Residues	7
Details	binding site for residue MLI A 934

Chain	Residue
A	LEU61
A	VAL62
A	TRP74
A	ARG669
A	GLU671
A	GOL915
A	HOH1392

site_id	AF8
Number of Residues	3
Details	binding site for residue MLI A 935

Chain	Residue
A	ASP28
A	LYS33
A	ARG171

site_id	AF9
Number of Residues	8
Details	binding site for residue MLI A 936

Chain	Residue
A	GLY335
A	SER336
A	ARG337
A	ALA338
A	NA907
A	HOH1177
A	HOH1463
A	HOH1581

site_id	AG1
Number of Residues	10
Details	binding site for residue MLI A 937

Chain	Residue
A	HIS11
A	ARG14
A	GLN467
A	ARG468
A	THR469
A	LYS478
A	GLN479
A	PRO480
A	HOH1244
A	HOH1336

site_id	AG2
Number of Residues	7
Details	binding site for residue MLI A 938

Chain	Residue
A	ASN579
A	HIS583
A	GLN587
A	LEU589
A	GLU639
A	VAL640
A	ALA643

site_id	AG3
Number of Residues	8
Details	binding site for residue MLI A 939

Chain	Residue
A	ARG641
A	GLU642
A	THR645
A	ARG686
A	ALA722
A	GOL927
A	HOH1023
A	HOH1119

site_id	AG4
Number of Residues	7
Details	binding site for residue MLI A 940

Chain	Residue
A	GLN111
A	GLY113
A	PHE257
A	SER777
A	HOH1126
A	HOH1144
A	HOH1276

site_id	AG5
Number of Residues	9
Details	binding site for residue MLI A 941

Chain	Residue
A	GLY261
A	ARG293
A	GLU298
A	TYR381
A	HT7902
A	GOL920
A	MLI942
A	HOH1065
A	HOH1225

site_id	AG6
Number of Residues	10
Details	binding site for residue MLI A 942

Chain	Residue
A	TYR376
A	THR377
A	LEU378
A	TYR381
A	GLU382
A	ARG825
A	GOL920
A	MLI941
A	HOH1214
A	HOH1373

site_id	AG7
Number of Residues	5
Details	binding site for residue MLI A 943

Chain	Residue
A	GLY396
A	GLU397
A	GLU398
A	HOH1002
A	HOH1048

site_id	AG8
Number of Residues	6
Details	binding site for residue MLI A 944

Chain	Residue
A	MET555
A	ARG556
A	ARG564
A	VAL602
A	ASP605
A	HOH1411

site_id	AG9
Number of Residues	9
Details	binding site for residue MLI A 945

Chain	Residue
A	GLU239
A	ARG240
A	PHE241
A	GLN401
A	GLN405
A	GLN585
A	GLN587
A	HOH1005
A	HOH1491

site_id	AH1
Number of Residues	9
Details	binding site for residue MLI A 946

Chain	Residue
A	ASP452
A	TYR544
A	LYS545
A	GLN550
A	NA904
A	GOL932
A	HOH1001
A	HOH1017
A	HOH1415

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEYFHNW

Chain	Residue	Details
A	VAL294-TRP303

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305\|PubMed:16885166, ECO:0000305\|PubMed:18416562, ECO:0000305\|PubMed:19622865

Chain	Residue	Details
A	GLU298

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING:

Chain	Residue	Details
A	GLU121
A	GLY261
A	HIS297
A	HIS301
A	GLU320

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000305

Chain	Residue	Details
A	TYR381

223532

PDB entries from 2024-08-07

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