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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4XNB

Crystal Structure of E. coli Aminopeptidase N in complex with L-Beta Homophenylalanine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 901

Chain	Residue
A	HIS297
A	HIS301
A	GLU320
A	3FB902

site_id	AC2
Number of Residues	15
Details	binding site for residue 3FB A 902

Chain	Residue
A	GLU264
A	HIS297
A	GLU298
A	HIS301
A	LYS319
A	GLU320
A	TYR376
A	TYR381
A	ZN901
A	GOL930
A	GLN119
A	GLU121
A	MET260
A	ALA262
A	MET263

site_id	AC3
Number of Residues	5
Details	binding site for residue NA A 903

Chain	Residue
A	GLN19
A	ILE20
A	LEU138
A	HOH1738
A	HOH1906

site_id	AC4
Number of Residues	5
Details	binding site for residue NA A 904

Chain	Residue
A	ASN67
A	THR91
A	HOH1872
A	HOH1887
A	HOH1907

site_id	AC5
Number of Residues	5
Details	binding site for residue NA A 905

Chain	Residue
A	HIS771
A	PHE774
A	HOH1172
A	HOH1716
A	HOH1810

site_id	AC6
Number of Residues	7
Details	binding site for residue NA A 906

Chain	Residue
A	ASP452
A	NA910
A	GOL915
A	HOH1058
A	HOH1683
A	HOH1798
A	HOH1817

site_id	AC7
Number of Residues	5
Details	binding site for residue NA A 907

Chain	Residue
A	ASP453
A	TYR454
A	HOH1247
A	HOH1496
A	HOH1729

site_id	AC8
Number of Residues	7
Details	binding site for residue NA A 908

Chain	Residue
A	SER332
A	ASP333
A	GLY335
A	HOH1038
A	HOH1513
A	HOH1773
A	HOH1846

site_id	AC9
Number of Residues	6
Details	binding site for residue NA A 909

Chain	Residue
A	GLU107
A	GLU371
A	HOH1143
A	HOH1144
A	HOH1228
A	HOH1460

site_id	AD1
Number of Residues	6
Details	binding site for residue NA A 910

Chain	Residue
A	ASP452
A	NA906
A	HOH1037
A	HOH1798
A	HOH1873
A	HOH1879

site_id	AD2
Number of Residues	9
Details	binding site for residue GOL A 911

Chain	Residue
A	LYS8
A	GLU123
A	ASP312
A	TRP313
A	PHE314
A	HOH1140
A	HOH1479
A	HOH1503
A	HOH1645

site_id	AD3
Number of Residues	8
Details	binding site for residue GOL A 912

Chain	Residue
A	PRO473
A	ASP474
A	GLN475
A	ALA476
A	HOH1065
A	HOH1090
A	HOH1181
A	HOH1557

site_id	AD4
Number of Residues	3
Details	binding site for residue GOL A 913

Chain	Residue
A	LYS144
A	TRP173
A	HOH1015

site_id	AD5
Number of Residues	10
Details	binding site for residue GOL A 914

Chain	Residue
A	SER63
A	VAL64
A	TRP71
A	TRP74
A	ARG669
A	VAL670
A	GLU671
A	GOL923
A	MLI933
A	HOH1422

site_id	AD6
Number of Residues	11
Details	binding site for residue GOL A 915

Chain	Residue
A	NA906
A	HOH1022
A	HOH1023
A	HOH1025
A	HOH1058
A	HOH1517
A	HOH1683
A	ASP452
A	TYR544
A	LYS545
A	GLN550

site_id	AD7
Number of Residues	8
Details	binding site for residue GOL A 916

Chain	Residue
A	LEU542
A	GLU543
A	TYR544
A	TRP546
A	HOH1035
A	HOH1195
A	HOH1364
A	HOH1524

site_id	AD8
Number of Residues	6
Details	binding site for residue GOL A 917

Chain	Residue
A	THR284
A	ASP285
A	LYS286
A	HOH1013
A	HOH1123
A	HOH1534

site_id	AD9
Number of Residues	4
Details	binding site for residue GOL A 918

Chain	Residue
A	GLU292
A	VAL670
A	HIS672
A	HOH1462

site_id	AE1
Number of Residues	6
Details	binding site for residue GOL A 919

Chain	Residue
A	THR393
A	CYS534
A	GLU535
A	HOH1047
A	HOH1098
A	HOH1577

site_id	AE2
Number of Residues	7
Details	binding site for residue GOL A 920

Chain	Residue
A	ARG346
A	THR347
A	LEU351
A	SER621
A	ASN623
A	GLU624
A	HOH1082

site_id	AE3
Number of Residues	4
Details	binding site for residue GOL A 921

Chain	Residue
A	LEU532
A	TRP546
A	ASP566
A	SER570

site_id	AE4
Number of Residues	5
Details	binding site for residue GOL A 922

Chain	Residue
A	ARG14
A	ALA15
A	PRO16
A	ASP17
A	HOH1227

site_id	AE5
Number of Residues	6
Details	binding site for residue GOL A 923

Chain	Residue
A	THR72
A	TRP74
A	VAL670
A	GOL914
A	HOH1462
A	HOH1794

site_id	AE6
Number of Residues	6
Details	binding site for residue GOL A 924

Chain	Residue
A	GLU409
A	ASP412
A	SER590
A	LEU591
A	HOH1300
A	HOH1629

site_id	AE7
Number of Residues	5
Details	binding site for residue GOL A 925

Chain	Residue
A	TYR376
A	LEU378
A	GLU382
A	GOL930
A	MLI934

site_id	AE8
Number of Residues	8
Details	binding site for residue GOL A 926

Chain	Residue
A	ARG641
A	THR645
A	ARG686
A	PHE690
A	ALA722
A	GOL928
A	HOH1029
A	HOH1272

site_id	AE9
Number of Residues	9
Details	binding site for residue GOL A 927

Chain	Residue
A	VAL622
A	THR755
A	PRO757
A	SER792
A	ASN793
A	GOL928
A	HOH1029
A	HOH1298
A	HOH1523

site_id	AF1
Number of Residues	10
Details	binding site for residue GOL A 928

Chain	Residue
A	ALA638
A	GLU642
A	PHE690
A	ALA722
A	PRO757
A	GOL926
A	GOL927
A	HOH1006
A	HOH1029
A	HOH1034

site_id	AF2
Number of Residues	8
Details	binding site for residue GOL A 929

Chain	Residue
A	ARG681
A	GLN703
A	ALA707
A	ASN708
A	ASN709
A	ASP712
A	HOH1095
A	HOH1545

site_id	AF3
Number of Residues	8
Details	binding site for residue GOL A 930

Chain	Residue
A	ARG293
A	HIS297
A	GLU298
A	3FB902
A	GOL925
A	HOH1070
A	HOH1121
A	HOH1166

site_id	AF4
Number of Residues	5
Details	binding site for residue GOL A 931

Chain	Residue
A	LYS402
A	GLN405
A	GLU409
A	HOH1041
A	HOH1042

site_id	AF5
Number of Residues	11
Details	binding site for residue GOL A 932

Chain	Residue
A	LEU289
A	ASP290
A	ARG293
A	ASN340
A	HOH1002
A	HOH1017
A	HOH1055
A	HOH1137
A	HOH1277
A	HOH1349
A	HOH1693

site_id	AF6
Number of Residues	10
Details	binding site for residue MLI A 933

Chain	Residue
A	LEU61
A	VAL62
A	VAL64
A	TRP74
A	ARG669
A	GLU671
A	GOL914
A	HOH1014
A	HOH1226
A	HOH1512

site_id	AF7
Number of Residues	8
Details	binding site for residue MLI A 934

Chain	Residue
A	MET260
A	GLY261
A	LYS274
A	TYR275
A	ARG783
A	ARG825
A	GOL925
A	HOH1121

site_id	AF8
Number of Residues	5
Details	binding site for residue MLI A 935

Chain	Residue
A	SER441
A	GLN442
A	GLN475
A	GLU477
A	GLN479

site_id	AF9
Number of Residues	9
Details	binding site for residue MLI A 936

Chain	Residue
A	GLY787
A	GLY791
A	ARG825
A	LEU826
A	PRO829
A	HOH1084
A	HOH1190
A	HOH1338
A	HOH1725

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEYFHNW

Chain	Residue	Details
A	VAL294-TRP303

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305\|PubMed:16885166, ECO:0000305\|PubMed:18416562, ECO:0000305\|PubMed:19622865

Chain	Residue	Details
A	GLU298

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING:

Chain	Residue	Details
A	GLU121
A	GLY261
A	HIS297
A	HIS301
A	GLU320

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000305

Chain	Residue	Details
A	TYR381

223532

PDB entries from 2024-08-07

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