4XN8
Crystal Structure of E. coli Aminopeptidase N in complex with L-Alanine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016285 | molecular_function | alanyl aminopeptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 901 |
| Chain | Residue |
| A | HIS297 |
| A | HIS301 |
| A | GLU320 |
| A | ALA902 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue ALA A 902 |
| Chain | Residue |
| A | HIS297 |
| A | GLU298 |
| A | HIS301 |
| A | LYS319 |
| A | GLU320 |
| A | TYR381 |
| A | ZN901 |
| A | MLI921 |
| A | GLU121 |
| A | MET260 |
| A | ALA262 |
| A | MET263 |
| A | GLU264 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 903 |
| Chain | Residue |
| A | HIS771 |
| A | PHE774 |
| A | HOH1345 |
| A | HOH1565 |
| A | HOH1902 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 904 |
| Chain | Residue |
| A | ASP452 |
| A | TYR544 |
| A | NA906 |
| A | HOH1394 |
| A | HOH1856 |
| A | HOH1929 |
| A | HOH1946 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 905 |
| Chain | Residue |
| A | SER332 |
| A | ASP333 |
| A | GLY335 |
| A | HOH1664 |
| A | HOH1850 |
| A | HOH1944 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 906 |
| Chain | Residue |
| A | ASP452 |
| A | NA904 |
| A | HOH1718 |
| A | HOH1907 |
| A | HOH1940 |
| A | HOH1946 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 907 |
| Chain | Residue |
| A | GLN19 |
| A | ILE20 |
| A | LEU138 |
| A | HOH1773 |
| A | HOH2006 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 908 |
| Chain | Residue |
| A | ASP24 |
| A | HOH1023 |
| A | HOH1438 |
| A | HOH2051 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 909 |
| Chain | Residue |
| A | TYR185 |
| A | GLU264 |
| A | GLY305 |
| A | ASN306 |
| A | LYS319 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 910 |
| Chain | Residue |
| A | TYR544 |
| A | HOH1546 |
| A | HOH1741 |
| A | HOH1950 |
| A | HOH2034 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 911 |
| Chain | Residue |
| A | GLU77 |
| A | ALA80 |
| A | TYR130 |
| A | HOH1374 |
| A | HOH1962 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 912 |
| Chain | Residue |
| A | ALA643 |
| A | THR647 |
| A | HOH2025 |
| A | HOH2065 |
| A | HOH2126 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 913 |
| Chain | Residue |
| A | GLU371 |
| A | HOH1049 |
| A | HOH1126 |
| A | HOH1192 |
| A | HOH1555 |
| A | HOH1878 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 914 |
| Chain | Residue |
| A | GLU371 |
| A | HOH1103 |
| A | HOH1251 |
| A | HOH1545 |
| A | HOH1878 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 915 |
| Chain | Residue |
| A | ASN623 |
| A | GLY791 |
| A | HOH1302 |
| A | HOH1636 |
| A | HOH1959 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 916 |
| Chain | Residue |
| A | GLY350 |
| A | ALA354 |
| A | ASN623 |
| A | GLU627 |
| A | HOH1636 |
| A | HOH1807 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 917 |
| Chain | Residue |
| A | GLU426 |
| A | ASP432 |
| A | SER434 |
| A | HOH1550 |
| A | HOH1913 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue MLI A 918 |
| Chain | Residue |
| A | TRP74 |
| A | ARG669 |
| A | GLU671 |
| A | HOH1685 |
| A | LEU61 |
| A | VAL62 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue MLI A 919 |
| Chain | Residue |
| A | ARG438 |
| A | HOH1765 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue MLI A 920 |
| Chain | Residue |
| A | TYR376 |
| A | GLU382 |
| A | ARG825 |
| A | MLI921 |
| site_id | AE3 |
| Number of Residues | 9 |
| Details | binding site for residue MLI A 921 |
| Chain | Residue |
| A | MET260 |
| A | ARG293 |
| A | VAL294 |
| A | HIS297 |
| A | ALA902 |
| A | MLI920 |
| A | HOH1062 |
| A | HOH1066 |
| A | HOH1307 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEYFHNW |
| Chain | Residue | Details |
| A | VAL294-TRP303 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"16885166","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18416562","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19622865","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
