4XN7
Crystal Structure of E. coli Aminopeptidase N in complex with L-2,3-Diaminopropionic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016285 | molecular_function | alanyl aminopeptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 901 |
| Chain | Residue |
| A | HIS297 |
| A | HIS301 |
| A | GLU320 |
| A | DPP902 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue DPP A 902 |
| Chain | Residue |
| A | GLU298 |
| A | HIS301 |
| A | LYS319 |
| A | GLU320 |
| A | TYR381 |
| A | ZN901 |
| A | HOH1032 |
| A | HOH1039 |
| A | GLU121 |
| A | ALA262 |
| A | MET263 |
| A | GLU264 |
| A | HIS297 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 903 |
| Chain | Residue |
| A | SER332 |
| A | ASP333 |
| A | GLY335 |
| A | HOH1332 |
| A | HOH1371 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 904 |
| Chain | Residue |
| A | ASP452 |
| A | GOL924 |
| A | HOH1344 |
| A | HOH1419 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 905 |
| Chain | Residue |
| A | GLY350 |
| A | ALA354 |
| A | ASN623 |
| A | GLU627 |
| A | HOH1392 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 906 |
| Chain | Residue |
| A | GLN19 |
| A | ILE20 |
| A | LEU138 |
| A | HOH1338 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 907 |
| Chain | Residue |
| A | LEU532 |
| A | TRP546 |
| A | ASP566 |
| A | ALA567 |
| A | SER570 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 908 |
| Chain | Residue |
| A | TYR376 |
| A | GLU382 |
| A | GOL933 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 909 |
| Chain | Residue |
| A | THR72 |
| A | TRP74 |
| A | VAL670 |
| A | GLU671 |
| A | GOL915 |
| A | HOH1072 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 910 |
| Chain | Residue |
| A | GLU69 |
| A | PRO70 |
| A | TRP71 |
| A | THR72 |
| A | PRO224 |
| A | ALA278 |
| A | TYR288 |
| A | HOH1076 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 911 |
| Chain | Residue |
| A | HIS11 |
| A | GLN467 |
| A | THR469 |
| A | LYS478 |
| A | PRO480 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 912 |
| Chain | Residue |
| A | MET360 |
| A | ALA361 |
| A | HIS362 |
| A | ASP367 |
| A | MET368 |
| A | PHE375 |
| A | LYS867 |
| A | GOL913 |
| A | HOH1118 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 913 |
| Chain | Residue |
| A | PRO363 |
| A | ASP367 |
| A | ASP474 |
| A | GLN475 |
| A | ALA476 |
| A | GOL912 |
| A | GOL914 |
| A | HOH1333 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 914 |
| Chain | Residue |
| A | PRO473 |
| A | ASP474 |
| A | ALA476 |
| A | GOL913 |
| A | HOH1029 |
| A | HOH1154 |
| site_id | AD6 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 915 |
| Chain | Residue |
| A | SER63 |
| A | VAL64 |
| A | TRP71 |
| A | TRP74 |
| A | ARG669 |
| A | VAL670 |
| A | GLU671 |
| A | GOL909 |
| A | MLI936 |
| A | HOH1169 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 916 |
| Chain | Residue |
| A | ALA870 |
| A | LYS834 |
| A | ARG845 |
| A | LYS852 |
| A | TYR862 |
| site_id | AD8 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 917 |
| Chain | Residue |
| A | LEU617 |
| A | THR618 |
| A | LEU619 |
| A | ARG641 |
| A | THR645 |
| A | ALA683 |
| A | ARG686 |
| A | PHE687 |
| A | GOL930 |
| A | HOH1207 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 918 |
| Chain | Residue |
| A | PHE180 |
| A | PRO181 |
| A | ARG307 |
| A | ASP412 |
| A | GLY413 |
| A | PRO592 |
| A | VAL593 |
| A | HIS594 |
| A | HOH1149 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 919 |
| Chain | Residue |
| A | ARG204 |
| A | GLU238 |
| A | GLU244 |
| A | ALA581 |
| A | ARG582 |
| A | GLN585 |
| A | GLN587 |
| A | HOH1038 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 920 |
| Chain | Residue |
| A | LEU29 |
| A | ASP30 |
| A | ALA31 |
| A | ALA147 |
| A | ASP148 |
| A | TYR152 |
| A | ARG171 |
| A | HOH1001 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 921 |
| Chain | Residue |
| A | GLU123 |
| A | TRP313 |
| A | PHE314 |
| A | HOH1093 |
| A | HOH1097 |
| A | HOH1273 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 922 |
| Chain | Residue |
| A | ARG10 |
| A | HIS11 |
| A | ARG311 |
| A | HOH1276 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 923 |
| Chain | Residue |
| A | GLN442 |
| A | GLN475 |
| A | GLU477 |
| A | GLU477 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 924 |
| Chain | Residue |
| A | ARG161 |
| A | ASP452 |
| A | PRO528 |
| A | NA904 |
| A | HOH1008 |
| A | HOH1269 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 925 |
| Chain | Residue |
| A | VAL162 |
| A | GLN177 |
| A | GLN549 |
| A | PHE553 |
| A | HOH1046 |
| A | HOH1082 |
| site_id | AE8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 926 |
| Chain | Residue |
| A | SER336 |
| A | ASN340 |
| A | HIS672 |
| A | GOL934 |
| A | HOH1009 |
| A | HOH1346 |
| site_id | AE9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 927 |
| Chain | Residue |
| A | ASN623 |
| A | ILE632 |
| A | HIS798 |
| A | PRO829 |
| A | ARG832 |
| A | TYR836 |
| A | HOH1234 |
| A | HOH1286 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 928 |
| Chain | Residue |
| A | TYR664 |
| A | ARG681 |
| A | GLN703 |
| A | ALA707 |
| A | ASN708 |
| A | ASP712 |
| A | HOH1035 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 929 |
| Chain | Residue |
| A | ASP58 |
| A | LYS60 |
| A | GLU97 |
| A | SER99 |
| site_id | AF3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 930 |
| Chain | Residue |
| A | ALA638 |
| A | ARG641 |
| A | ARG686 |
| A | PHE690 |
| A | GOL917 |
| A | HOH1064 |
| A | HOH1456 |
| site_id | AF4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 931 |
| Chain | Residue |
| A | ARG728 |
| A | GLN753 |
| A | SER756 |
| A | ALA758 |
| A | ASN760 |
| A | THR764 |
| site_id | AF5 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 932 |
| Chain | Residue |
| A | GLU244 |
| A | TYR245 |
| A | ASP246 |
| A | TRP303 |
| A | ARG307 |
| A | LEU578 |
| A | SER590 |
| A | LEU591 |
| A | PRO592 |
| A | HOH1025 |
| A | HOH1051 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 933 |
| Chain | Residue |
| A | GLY261 |
| A | LYS274 |
| A | TYR275 |
| A | ARG783 |
| A | ARG825 |
| A | GOL908 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 934 |
| Chain | Residue |
| A | LEU289 |
| A | THR679 |
| A | GOL926 |
| A | HOH1136 |
| A | HOH1225 |
| A | HOH1346 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue MLI A 935 |
| Chain | Residue |
| A | ASN623 |
| A | GLY791 |
| A | SER792 |
| A | HOH1275 |
| site_id | AF9 |
| Number of Residues | 7 |
| Details | binding site for residue MLI A 936 |
| Chain | Residue |
| A | LEU61 |
| A | VAL62 |
| A | TRP74 |
| A | ARG669 |
| A | GLU671 |
| A | GOL915 |
| A | HOH1254 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEYFHNW |
| Chain | Residue | Details |
| A | VAL294-TRP303 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"16885166","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18416562","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19622865","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
