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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4XN7

Crystal Structure of E. coli Aminopeptidase N in complex with L-2,3-Diaminopropionic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 901

Chain	Residue
A	HIS297
A	HIS301
A	GLU320
A	DPP902

site_id	AC2
Number of Residues	13
Details	binding site for residue DPP A 902

Chain	Residue
A	GLU298
A	HIS301
A	LYS319
A	GLU320
A	TYR381
A	ZN901
A	HOH1032
A	HOH1039
A	GLU121
A	ALA262
A	MET263
A	GLU264
A	HIS297

site_id	AC3
Number of Residues	5
Details	binding site for residue NA A 903

Chain	Residue
A	SER332
A	ASP333
A	GLY335
A	HOH1332
A	HOH1371

site_id	AC4
Number of Residues	4
Details	binding site for residue NA A 904

Chain	Residue
A	ASP452
A	GOL924
A	HOH1344
A	HOH1419

site_id	AC5
Number of Residues	5
Details	binding site for residue NA A 905

Chain	Residue
A	GLY350
A	ALA354
A	ASN623
A	GLU627
A	HOH1392

site_id	AC6
Number of Residues	4
Details	binding site for residue NA A 906

Chain	Residue
A	GLN19
A	ILE20
A	LEU138
A	HOH1338

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL A 907

Chain	Residue
A	LEU532
A	TRP546
A	ASP566
A	ALA567
A	SER570

site_id	AC8
Number of Residues	3
Details	binding site for residue GOL A 908

Chain	Residue
A	TYR376
A	GLU382
A	GOL933

site_id	AC9
Number of Residues	6
Details	binding site for residue GOL A 909

Chain	Residue
A	THR72
A	TRP74
A	VAL670
A	GLU671
A	GOL915
A	HOH1072

site_id	AD1
Number of Residues	8
Details	binding site for residue GOL A 910

Chain	Residue
A	GLU69
A	PRO70
A	TRP71
A	THR72
A	PRO224
A	ALA278
A	TYR288
A	HOH1076

site_id	AD2
Number of Residues	5
Details	binding site for residue GOL A 911

Chain	Residue
A	HIS11
A	GLN467
A	THR469
A	LYS478
A	PRO480

site_id	AD3
Number of Residues	9
Details	binding site for residue GOL A 912

Chain	Residue
A	MET360
A	ALA361
A	HIS362
A	ASP367
A	MET368
A	PHE375
A	LYS867
A	GOL913
A	HOH1118

site_id	AD4
Number of Residues	8
Details	binding site for residue GOL A 913

Chain	Residue
A	PRO363
A	ASP367
A	ASP474
A	GLN475
A	ALA476
A	GOL912
A	GOL914
A	HOH1333

site_id	AD5
Number of Residues	6
Details	binding site for residue GOL A 914

Chain	Residue
A	PRO473
A	ASP474
A	ALA476
A	GOL913
A	HOH1029
A	HOH1154

site_id	AD6
Number of Residues	10
Details	binding site for residue GOL A 915

Chain	Residue
A	SER63
A	VAL64
A	TRP71
A	TRP74
A	ARG669
A	VAL670
A	GLU671
A	GOL909
A	MLI936
A	HOH1169

site_id	AD7
Number of Residues	5
Details	binding site for residue GOL A 916

Chain	Residue
A	ALA870
A	LYS834
A	ARG845
A	LYS852
A	TYR862

site_id	AD8
Number of Residues	10
Details	binding site for residue GOL A 917

Chain	Residue
A	LEU617
A	THR618
A	LEU619
A	ARG641
A	THR645
A	ALA683
A	ARG686
A	PHE687
A	GOL930
A	HOH1207

site_id	AD9
Number of Residues	9
Details	binding site for residue GOL A 918

Chain	Residue
A	PHE180
A	PRO181
A	ARG307
A	ASP412
A	GLY413
A	PRO592
A	VAL593
A	HIS594
A	HOH1149

site_id	AE1
Number of Residues	8
Details	binding site for residue GOL A 919

Chain	Residue
A	ARG204
A	GLU238
A	GLU244
A	ALA581
A	ARG582
A	GLN585
A	GLN587
A	HOH1038

site_id	AE2
Number of Residues	8
Details	binding site for residue GOL A 920

Chain	Residue
A	LEU29
A	ASP30
A	ALA31
A	ALA147
A	ASP148
A	TYR152
A	ARG171
A	HOH1001

site_id	AE3
Number of Residues	6
Details	binding site for residue GOL A 921

Chain	Residue
A	GLU123
A	TRP313
A	PHE314
A	HOH1093
A	HOH1097
A	HOH1273

site_id	AE4
Number of Residues	4
Details	binding site for residue GOL A 922

Chain	Residue
A	ARG10
A	HIS11
A	ARG311
A	HOH1276

site_id	AE5
Number of Residues	4
Details	binding site for residue GOL A 923

Chain	Residue
A	GLN442
A	GLN475
A	GLU477
A	GLU477

site_id	AE6
Number of Residues	6
Details	binding site for residue GOL A 924

Chain	Residue
A	ARG161
A	ASP452
A	PRO528
A	NA904
A	HOH1008
A	HOH1269

site_id	AE7
Number of Residues	6
Details	binding site for residue GOL A 925

Chain	Residue
A	VAL162
A	GLN177
A	GLN549
A	PHE553
A	HOH1046
A	HOH1082

site_id	AE8
Number of Residues	6
Details	binding site for residue GOL A 926

Chain	Residue
A	SER336
A	ASN340
A	HIS672
A	GOL934
A	HOH1009
A	HOH1346

site_id	AE9
Number of Residues	8
Details	binding site for residue GOL A 927

Chain	Residue
A	ASN623
A	ILE632
A	HIS798
A	PRO829
A	ARG832
A	TYR836
A	HOH1234
A	HOH1286

site_id	AF1
Number of Residues	7
Details	binding site for residue GOL A 928

Chain	Residue
A	TYR664
A	ARG681
A	GLN703
A	ALA707
A	ASN708
A	ASP712
A	HOH1035

site_id	AF2
Number of Residues	4
Details	binding site for residue GOL A 929

Chain	Residue
A	ASP58
A	LYS60
A	GLU97
A	SER99

site_id	AF3
Number of Residues	7
Details	binding site for residue GOL A 930

Chain	Residue
A	ALA638
A	ARG641
A	ARG686
A	PHE690
A	GOL917
A	HOH1064
A	HOH1456

site_id	AF4
Number of Residues	6
Details	binding site for residue GOL A 931

Chain	Residue
A	ARG728
A	GLN753
A	SER756
A	ALA758
A	ASN760
A	THR764

site_id	AF5
Number of Residues	11
Details	binding site for residue GOL A 932

Chain	Residue
A	GLU244
A	TYR245
A	ASP246
A	TRP303
A	ARG307
A	LEU578
A	SER590
A	LEU591
A	PRO592
A	HOH1025
A	HOH1051

site_id	AF6
Number of Residues	6
Details	binding site for residue GOL A 933

Chain	Residue
A	GLY261
A	LYS274
A	TYR275
A	ARG783
A	ARG825
A	GOL908

site_id	AF7
Number of Residues	6
Details	binding site for residue GOL A 934

Chain	Residue
A	LEU289
A	THR679
A	GOL926
A	HOH1136
A	HOH1225
A	HOH1346

site_id	AF8
Number of Residues	4
Details	binding site for residue MLI A 935

Chain	Residue
A	ASN623
A	GLY791
A	SER792
A	HOH1275

site_id	AF9
Number of Residues	7
Details	binding site for residue MLI A 936

Chain	Residue
A	LEU61
A	VAL62
A	TRP74
A	ARG669
A	GLU671
A	GOL915
A	HOH1254

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEYFHNW

Chain	Residue	Details
A	VAL294-TRP303

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305\|PubMed:16885166, ECO:0000305\|PubMed:18416562, ECO:0000305\|PubMed:19622865

Chain	Residue	Details
A	GLU298

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING:

Chain	Residue	Details
A	HIS301
A	GLU320
A	GLU121
A	GLY261
A	HIS297

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000305

Chain	Residue	Details
A	TYR381

221051

PDB entries from 2024-06-12

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