4XME
Crystal structure of nitrophorin 7 from Rhodnius prolixus at pH 7.8 complexed with NO
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0035738 | biological_process | venom-mediated perturbation of biological process |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042311 | biological_process | vasodilation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051381 | molecular_function | histamine binding |
| A | 0070026 | molecular_function | nitric oxide binding |
| A | 0090729 | molecular_function | toxin activity |
| A | 0097746 | biological_process | blood vessel diameter maintenance |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue HEM A 201 |
| Chain | Residue |
| A | GLU27 |
| A | PHE88 |
| A | THR90 |
| A | TYR107 |
| A | VAL109 |
| A | ILE121 |
| A | ILE123 |
| A | LEU135 |
| A | SER137 |
| A | NO202 |
| A | HOH335 |
| A | TYR30 |
| A | HOH422 |
| A | PHE41 |
| A | PHE43 |
| A | GLU56 |
| A | LEU58 |
| A | HIS60 |
| A | PHE69 |
| A | ASN71 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue NO A 202 |
| Chain | Residue |
| A | ILE123 |
| A | HEM201 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 203 |
| Chain | Residue |
| A | THR72 |
| A | GLY73 |
| A | THR74 |
| A | LYS87 |
| A | ASN89 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26167269, ECO:0007744|PDB:4XMF |
| Chain | Residue | Details |
| A | ASP32 | |
| A | ASP134 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: proximal binding residue => ECO:0000269|PubMed:26167269, ECO:0007744|PDB:4XMC, ECO:0007744|PDB:4XMD, ECO:0007744|PDB:4XME, ECO:0007744|PDB:4XMF, ECO:0007744|PDB:4XMG, ECO:0007744|PDB:4XMH |
| Chain | Residue | Details |
| A | HIS60 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26167269, ECO:0007744|PDB:4XMC, ECO:0007744|PDB:4XME |
| Chain | Residue | Details |
| A | ASN71 |
