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Crystal structure of 2,2'-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetamide bound to human Keap1 Kelch domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0008134molecular_functiontranscription factor binding
A0016567biological_processprotein ubiquitination
A0031463cellular_componentCul3-RING ubiquitin ligase complex
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue 41P A 701
ChainResidue
ATYR334
ASER508
AGLY509
ATYR525
AGLN530
ASER555
AALA556
APHE577
ASER602
AGLY603
ASER363
AGLY364
AARG380
AASN414
AARG415
AILE461
AGLY462
APHE478

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Sensor for electrophilic agents => ECO:0000250|UniProtKB:Q9Z2X8
ChainResidueDetails
ACYS434

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: S-cGMP-cysteine => ECO:0000250|UniProtKB:Q9Z2X8
ChainResidueDetails
ACYS434

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PDB entries from 2024-07-31

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