4XJT

Human CD38 complexed with inhibitor 2 [4-[(2,6-dimethylbenzyl)amino]-2-methylquinoline-8-carboxamide]

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0061809	molecular_function	NAD+ nucleotidase, cyclic ADP-ribose generating

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue 41Z A 401

Chain	Residue
A	LYS129
A	GLU146
A	ASP155
A	SER186
A	TRP189
A	THR221
A	NA7402
A	HOH523

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site_id	AC2
Number of Residues	15
Details	binding site for residue NA7 A 402

Chain	Residue
A	SER126
A	ARG127
A	TRP176
A	SER193
A	ASP219
A	SER220
A	THR221
A	PHE222
A	GLN226
A	41Z401
A	HOH521
A	HOH536
A	HOH537
A	HOH539
A	TRP125

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:7961800

Chain	Residue	Details
A	CYS119
A	CYS201

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASP100
A	ASP209

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ALA164

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASP219

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