4XJC
dCTP deaminase-dUTPase from Bacillus halodurans
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0006226 | biological_process | dUMP biosynthetic process |
| A | 0006229 | biological_process | dUTP biosynthetic process |
| A | 0008829 | molecular_function | dCTP deaminase activity |
| A | 0009117 | biological_process | nucleotide metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0033973 | molecular_function | dCTP deaminase (dUMP-forming) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0006226 | biological_process | dUMP biosynthetic process |
| B | 0006229 | biological_process | dUTP biosynthetic process |
| B | 0008829 | molecular_function | dCTP deaminase activity |
| B | 0009117 | biological_process | nucleotide metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0033973 | molecular_function | dCTP deaminase (dUMP-forming) activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0006226 | biological_process | dUMP biosynthetic process |
| C | 0006229 | biological_process | dUTP biosynthetic process |
| C | 0008829 | molecular_function | dCTP deaminase activity |
| C | 0009117 | biological_process | nucleotide metabolic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0033973 | molecular_function | dCTP deaminase (dUMP-forming) activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0006226 | biological_process | dUMP biosynthetic process |
| D | 0006229 | biological_process | dUTP biosynthetic process |
| D | 0008829 | molecular_function | dCTP deaminase activity |
| D | 0009117 | biological_process | nucleotide metabolic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0033973 | molecular_function | dCTP deaminase (dUMP-forming) activity |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0006226 | biological_process | dUMP biosynthetic process |
| E | 0006229 | biological_process | dUTP biosynthetic process |
| E | 0008829 | molecular_function | dCTP deaminase activity |
| E | 0009117 | biological_process | nucleotide metabolic process |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0033973 | molecular_function | dCTP deaminase (dUMP-forming) activity |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0006226 | biological_process | dUMP biosynthetic process |
| F | 0006229 | biological_process | dUTP biosynthetic process |
| F | 0008829 | molecular_function | dCTP deaminase activity |
| F | 0009117 | biological_process | nucleotide metabolic process |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0033973 | molecular_function | dCTP deaminase (dUMP-forming) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue TTP A 201 |
| Chain | Residue |
| A | ASN110 |
| A | TYR161 |
| A | GLN164 |
| A | HOH312 |
| A | HOH325 |
| A | HOH333 |
| E | ARG98 |
| E | SER99 |
| E | SER100 |
| E | ARG103 |
| E | GLN144 |
| A | GLY112 |
| E | MG201 |
| E | HOH319 |
| E | HOH320 |
| E | HOH330 |
| A | ASP115 |
| A | PHE118 |
| A | ILE122 |
| A | THR123 |
| A | TYR157 |
| A | GLY159 |
| A | LYS160 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | HOH313 |
| A | HOH314 |
| C | TTP201 |
| C | HOH308 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 203 |
| Chain | Residue |
| A | PRO88 |
| A | ASN89 |
| A | HIS90 |
| A | HOH307 |
| A | HOH310 |
| site_id | AC4 |
| Number of Residues | 24 |
| Details | binding site for residue TTP C 201 |
| Chain | Residue |
| A | ARG98 |
| A | SER99 |
| A | SER100 |
| A | ARG103 |
| A | GLN144 |
| A | MG202 |
| A | HOH313 |
| A | HOH314 |
| A | HOH321 |
| C | ASN110 |
| C | GLY112 |
| C | VAL114 |
| C | ASP115 |
| C | PHE118 |
| C | ILE122 |
| C | THR123 |
| C | TYR157 |
| C | GLY159 |
| C | LYS160 |
| C | TYR161 |
| C | GLN164 |
| C | HOH308 |
| C | HOH315 |
| C | HOH329 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue MG C 202 |
| Chain | Residue |
| C | HOH309 |
| E | TTP202 |
| E | HOH321 |
| E | HOH322 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue MG E 201 |
| Chain | Residue |
| A | TTP201 |
| A | HOH312 |
| E | HOH319 |
| E | HOH320 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | binding site for residue TTP E 202 |
| Chain | Residue |
| C | ARG98 |
| C | SER99 |
| C | SER100 |
| C | ARG103 |
| C | GLN144 |
| C | MG202 |
| C | HOH309 |
| C | HOH311 |
| E | VAL95 |
| E | ASN110 |
| E | GLY112 |
| E | ASP115 |
| E | PHE118 |
| E | ILE122 |
| E | THR123 |
| E | TYR157 |
| E | GLY159 |
| E | LYS160 |
| E | TYR161 |
| E | GLN164 |
| E | HOH321 |
| E | HOH322 |
| E | HOH324 |
| site_id | AC8 |
| Number of Residues | 22 |
| Details | binding site for residue TTP B 201 |
| Chain | Residue |
| F | ARG98 |
| F | SER99 |
| F | SER100 |
| F | ARG103 |
| F | GLN144 |
| F | MG201 |
| F | HOH306 |
| F | HOH307 |
| F | HOH316 |
| F | HOH318 |
| B | ASN110 |
| B | GLY112 |
| B | ASP115 |
| B | PHE118 |
| B | ILE122 |
| B | THR123 |
| B | TYR157 |
| B | GLY159 |
| B | LYS160 |
| B | TYR161 |
| B | GLN164 |
| B | HOH357 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| B | HOH317 |
| B | HOH318 |
| D | TTP201 |
| D | HOH318 |
| site_id | AD1 |
| Number of Residues | 24 |
| Details | binding site for residue TTP D 201 |
| Chain | Residue |
| B | ARG98 |
| B | SER99 |
| B | SER100 |
| B | ARG103 |
| B | GLN144 |
| B | MG202 |
| B | HOH317 |
| B | HOH318 |
| B | HOH345 |
| D | ASN110 |
| D | GLY112 |
| D | ASP115 |
| D | PHE118 |
| D | ILE122 |
| D | THR123 |
| D | TYR157 |
| D | GLY159 |
| D | LYS160 |
| D | TYR161 |
| D | GLN164 |
| D | HOH318 |
| D | HOH320 |
| D | HOH333 |
| D | HOH354 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 202 |
| Chain | Residue |
| D | HOH319 |
| D | HOH356 |
| F | TTP202 |
| F | HOH308 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue MG F 201 |
| Chain | Residue |
| B | TTP201 |
| B | HOH316 |
| F | HOH306 |
| F | HOH307 |
| site_id | AD4 |
| Number of Residues | 21 |
| Details | binding site for residue TTP F 202 |
| Chain | Residue |
| D | ARG98 |
| D | SER99 |
| D | SER100 |
| D | ARG103 |
| D | GLN144 |
| D | MG202 |
| D | HOH319 |
| D | HOH356 |
| F | ASN110 |
| F | ASP115 |
| F | PHE118 |
| F | ILE122 |
| F | THR123 |
| F | TYR157 |
| F | GLY159 |
| F | LYS160 |
| F | TYR161 |
| F | GLN164 |
| F | HOH308 |
| F | HOH320 |
| F | HOH332 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:P28248, ECO:0000255|HAMAP-Rule:MF_00146 |
| Chain | Residue | Details |
| A | GLU125 | |
| C | GLU125 | |
| E | GLU125 | |
| B | GLU125 | |
| D | GLU125 | |
| F | GLU125 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00146, ECO:0000305|PubMed:25746996 |
| Chain | Residue | Details |
| A | ARG98 | |
| E | THR123 | |
| E | GLN144 | |
| E | GLN164 | |
| B | ARG98 | |
| B | THR123 | |
| B | GLN144 | |
| B | GLN164 | |
| D | ARG98 | |
| D | THR123 | |
| D | GLN144 | |
| A | THR123 | |
| D | GLN164 | |
| F | ARG98 | |
| F | THR123 | |
| F | GLN144 | |
| F | GLN164 | |
| A | GLN144 | |
| A | GLN164 | |
| C | ARG98 | |
| C | THR123 | |
| C | GLN144 | |
| C | GLN164 | |
| E | ARG98 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:25746996 |
| Chain | Residue | Details |
| A | ASN110 | |
| B | ASN110 | |
| B | ASP115 | |
| B | TYR157 | |
| D | ASN110 | |
| D | ASP115 | |
| D | TYR157 | |
| F | ASN110 | |
| F | ASP115 | |
| F | TYR157 | |
| A | ASP115 | |
| A | TYR157 | |
| C | ASN110 | |
| C | ASP115 | |
| C | TYR157 | |
| E | ASN110 | |
| E | ASP115 | |
| E | TYR157 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | SITE: Important for bifunctional activity => ECO:0000255|HAMAP-Rule:MF_00146 |
| Chain | Residue | Details |
| A | GLY112 | |
| C | GLY112 | |
| E | GLY112 | |
| B | GLY112 | |
| D | GLY112 | |
| F | GLY112 |
