4XJC

dCTP deaminase-dUTPase from Bacillus halodurans

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0006226	biological_process	dUMP biosynthetic process
A	0006229	biological_process	dUTP biosynthetic process
A	0008829	molecular_function	dCTP deaminase activity
A	0009117	biological_process	nucleotide metabolic process
A	0016787	molecular_function	hydrolase activity
A	0033973	molecular_function	dCTP deaminase (dUMP-forming) activity
B	0000166	molecular_function	nucleotide binding
B	0006226	biological_process	dUMP biosynthetic process
B	0006229	biological_process	dUTP biosynthetic process
B	0008829	molecular_function	dCTP deaminase activity
B	0009117	biological_process	nucleotide metabolic process
B	0016787	molecular_function	hydrolase activity
B	0033973	molecular_function	dCTP deaminase (dUMP-forming) activity
C	0000166	molecular_function	nucleotide binding
C	0006226	biological_process	dUMP biosynthetic process
C	0006229	biological_process	dUTP biosynthetic process
C	0008829	molecular_function	dCTP deaminase activity
C	0009117	biological_process	nucleotide metabolic process
C	0016787	molecular_function	hydrolase activity
C	0033973	molecular_function	dCTP deaminase (dUMP-forming) activity
D	0000166	molecular_function	nucleotide binding
D	0006226	biological_process	dUMP biosynthetic process
D	0006229	biological_process	dUTP biosynthetic process
D	0008829	molecular_function	dCTP deaminase activity
D	0009117	biological_process	nucleotide metabolic process
D	0016787	molecular_function	hydrolase activity
D	0033973	molecular_function	dCTP deaminase (dUMP-forming) activity
E	0000166	molecular_function	nucleotide binding
E	0006226	biological_process	dUMP biosynthetic process
E	0006229	biological_process	dUTP biosynthetic process
E	0008829	molecular_function	dCTP deaminase activity
E	0009117	biological_process	nucleotide metabolic process
E	0016787	molecular_function	hydrolase activity
E	0033973	molecular_function	dCTP deaminase (dUMP-forming) activity
F	0000166	molecular_function	nucleotide binding
F	0006226	biological_process	dUMP biosynthetic process
F	0006229	biological_process	dUTP biosynthetic process
F	0008829	molecular_function	dCTP deaminase activity
F	0009117	biological_process	nucleotide metabolic process
F	0016787	molecular_function	hydrolase activity
F	0033973	molecular_function	dCTP deaminase (dUMP-forming) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue TTP A 201

Chain	Residue
A	ASN110
A	TYR161
A	GLN164
A	HOH312
A	HOH325
A	HOH333
E	ARG98
E	SER99
E	SER100
E	ARG103
E	GLN144
A	GLY112
E	MG201
E	HOH319
E	HOH320
E	HOH330
A	ASP115
A	PHE118
A	ILE122
A	THR123
A	TYR157
A	GLY159
A	LYS160

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 202

Chain	Residue
A	HOH313
A	HOH314
C	TTP201
C	HOH308

---

site_id	AC3
Number of Residues	5
Details	binding site for residue PEG A 203

Chain	Residue
A	PRO88
A	ASN89
A	HIS90
A	HOH307
A	HOH310

---

site_id	AC4
Number of Residues	24
Details	binding site for residue TTP C 201

Chain	Residue
A	ARG98
A	SER99
A	SER100
A	ARG103
A	GLN144
A	MG202
A	HOH313
A	HOH314
A	HOH321
C	ASN110
C	GLY112
C	VAL114
C	ASP115
C	PHE118
C	ILE122
C	THR123
C	TYR157
C	GLY159
C	LYS160
C	TYR161
C	GLN164
C	HOH308
C	HOH315
C	HOH329

---

site_id	AC5
Number of Residues	4
Details	binding site for residue MG C 202

Chain	Residue
C	HOH309
E	TTP202
E	HOH321
E	HOH322

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MG E 201

Chain	Residue
A	TTP201
A	HOH312
E	HOH319
E	HOH320

---

site_id	AC7
Number of Residues	23
Details	binding site for residue TTP E 202

Chain	Residue
C	ARG98
C	SER99
C	SER100
C	ARG103
C	GLN144
C	MG202
C	HOH309
C	HOH311
E	VAL95
E	ASN110
E	GLY112
E	ASP115
E	PHE118
E	ILE122
E	THR123
E	TYR157
E	GLY159
E	LYS160
E	TYR161
E	GLN164
E	HOH321
E	HOH322
E	HOH324

---

site_id	AC8
Number of Residues	22
Details	binding site for residue TTP B 201

Chain	Residue
F	ARG98
F	SER99
F	SER100
F	ARG103
F	GLN144
F	MG201
F	HOH306
F	HOH307
F	HOH316
F	HOH318
B	ASN110
B	GLY112
B	ASP115
B	PHE118
B	ILE122
B	THR123
B	TYR157
B	GLY159
B	LYS160
B	TYR161
B	GLN164
B	HOH357

---

site_id	AC9
Number of Residues	4
Details	binding site for residue MG B 202

Chain	Residue
B	HOH317
B	HOH318
D	TTP201
D	HOH318

---

site_id	AD1
Number of Residues	24
Details	binding site for residue TTP D 201

Chain	Residue
B	ARG98
B	SER99
B	SER100
B	ARG103
B	GLN144
B	MG202
B	HOH317
B	HOH318
B	HOH345
D	ASN110
D	GLY112
D	ASP115
D	PHE118
D	ILE122
D	THR123
D	TYR157
D	GLY159
D	LYS160
D	TYR161
D	GLN164
D	HOH318
D	HOH320
D	HOH333
D	HOH354

---

site_id	AD2
Number of Residues	4
Details	binding site for residue MG D 202

Chain	Residue
D	HOH319
D	HOH356
F	TTP202
F	HOH308

---

site_id	AD3
Number of Residues	4
Details	binding site for residue MG F 201

Chain	Residue
B	TTP201
B	HOH316
F	HOH306
F	HOH307

---

site_id	AD4
Number of Residues	21
Details	binding site for residue TTP F 202

Chain	Residue
D	ARG98
D	SER99
D	SER100
D	ARG103
D	GLN144
D	MG202
D	HOH319
D	HOH356
F	ASN110
F	ASP115
F	PHE118
F	ILE122
F	THR123
F	TYR157
F	GLY159
F	LYS160
F	TYR161
F	GLN164
F	HOH308
F	HOH320
F	HOH332

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P28248","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_00146","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	54
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00146","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25746996","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25746996","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Site: {"description":"Important for bifunctional activity","evidences":[{"source":"HAMAP-Rule","id":"MF_00146","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---