4XI3
Estrogen Receptor Alpha Ligand Binding Domain in Complex with Bazedoxifene
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue 29S A 601 |
| Chain | Residue |
| A | LEU346 |
| A | LEU525 |
| A | ASN532 |
| A | VAL533 |
| A | PRO535 |
| A | THR347 |
| A | ASP351 |
| A | GLU353 |
| A | LEU391 |
| A | ARG394 |
| A | PHE404 |
| A | ILE424 |
| A | HIS524 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue 29S B 601 |
| Chain | Residue |
| B | LEU346 |
| B | THR347 |
| B | ALA350 |
| B | ASP351 |
| B | GLU353 |
| B | LEU354 |
| B | TRP383 |
| B | LEU387 |
| B | LEU391 |
| B | ARG394 |
| B | ILE424 |
| B | GLY521 |
| B | HIS524 |
| B | LEU525 |
| B | VAL533 |
| B | PRO535 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue 29S C 601 |
| Chain | Residue |
| C | LEU346 |
| C | THR347 |
| C | ASP351 |
| C | GLU353 |
| C | MET388 |
| C | ARG394 |
| C | ILE424 |
| C | HIS524 |
| C | LEU525 |
| C | ASN532 |
| C | VAL533 |
| C | HOH706 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide 29S D 601 and HIS D 524 |
| Chain | Residue |
| D | ALA350 |
| D | ASP351 |
| D | GLU353 |
| D | LEU354 |
| D | TRP383 |
| D | LEU387 |
| D | LEU391 |
| D | ARG394 |
| D | GLU419 |
| D | GLY420 |
| D | MET421 |
| D | ILE424 |
| D | LYS520 |
| D | GLY521 |
| D | MET522 |
| D | GLU523 |
| D | LEU525 |
| D | TYR526 |
| D | SER527 |
| D | MET528 |
| D | ASN532 |
| D | PRO535 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE |
| Chain | Residue | Details |
| A | GLU353 | |
| D | GLU353 | |
| D | ARG394 | |
| D | HIS524 | |
| A | ARG394 | |
| A | HIS524 | |
| B | GLU353 | |
| B | ARG394 | |
| B | HIS524 | |
| C | GLU353 | |
| C | ARG394 | |
| C | HIS524 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 |
| Chain | Residue | Details |
| A | TYR537 | |
| B | TYR537 | |
| C | TYR537 | |
| D | TYR537 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS447 | |
| C | CYS447 | |
| D | CYS447 |
