4XHU
The complex structure of Timeless_PAB and PARP-1_catalytic domain
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 1101 |
| Chain | Residue |
| C | ASP770 |
| C | HIS862 |
| C | SER864 |
| C | ASN868 |
| C | HOH1230 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 1102 |
| Chain | Residue |
| C | ARG841 |
| C | GLY843 |
| C | GLU844 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT C 1103 |
| Chain | Residue |
| C | GLY863 |
| C | SER904 |
| C | TYR907 |
| C | HIS862 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL D 201 |
| Chain | Residue |
| A | ASP957 |
| D | LEU25 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1101 |
| Chain | Residue |
| A | ASP766 |
| A | ASP770 |
| A | HIS862 |
| A | SER864 |
| A | ASN868 |
| A | CA1103 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 1102 |
| Chain | Residue |
| A | HIS862 |
| A | GLY863 |
| A | TYR896 |
| A | SER904 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 1103 |
| Chain | Residue |
| A | ASP766 |
| A | GOL1101 |
| A | HOH1220 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For poly [ADP-ribose] polymerase activity","evidences":[{"source":"PubMed","id":"32028527","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7852410","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9315851","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9UGN5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
