4XFP
Crystal Structure of Highly Active Mutant of Bacillus sp. TB-90 Urate Oxidase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004846 | molecular_function | urate oxidase activity |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| B | 0004846 | molecular_function | urate oxidase activity |
| B | 0006144 | biological_process | purine nucleobase metabolic process |
| C | 0004846 | molecular_function | urate oxidase activity |
| C | 0006144 | biological_process | purine nucleobase metabolic process |
| D | 0004846 | molecular_function | urate oxidase activity |
| D | 0006144 | biological_process | purine nucleobase metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue AZA A 401 |
| Chain | Residue |
| A | PHE184 |
| A | HOH696 |
| B | TYR11 |
| B | ALA72 |
| B | THR73 |
| A | LEU195 |
| A | ARG201 |
| A | SER248 |
| A | ILE249 |
| A | GLN250 |
| A | ASN276 |
| A | CL402 |
| A | HOH622 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | ASN276 |
| A | GLY302 |
| A | GLN304 |
| A | AZA401 |
| B | THR73 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | ARG298 |
| C | ARG298 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue AZA B 401 |
| Chain | Residue |
| A | ALA72 |
| A | THR73 |
| B | PHE184 |
| B | LEU195 |
| B | ARG201 |
| B | SER248 |
| B | ILE249 |
| B | GLN250 |
| B | ASN276 |
| B | CL402 |
| B | HOH588 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue CL B 402 |
| Chain | Residue |
| A | THR73 |
| A | HOH710 |
| B | ASN276 |
| B | GLY302 |
| B | GLN304 |
| B | AZA401 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue AZA C 401 |
| Chain | Residue |
| C | PHE184 |
| C | ARG201 |
| C | SER248 |
| C | ILE249 |
| C | GLN250 |
| C | ASN276 |
| C | CL402 |
| C | HOH573 |
| D | ALA72 |
| D | THR73 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue CL C 402 |
| Chain | Residue |
| C | ASN276 |
| C | GLY302 |
| C | GLN304 |
| C | AZA401 |
| D | THR73 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 401 |
| Chain | Residue |
| B | ARG298 |
| D | ARG298 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | binding site for residue AZA D 402 |
| Chain | Residue |
| C | ALA72 |
| C | THR73 |
| C | HOH701 |
| D | PHE184 |
| D | ARG201 |
| D | SER248 |
| D | ILE249 |
| D | GLN250 |
| D | ASN276 |
| D | CL403 |
| D | HOH592 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue CL D 403 |
| Chain | Residue |
| C | THR73 |
| D | ASN276 |
| D | GLY302 |
| D | GLN304 |
| D | AZA402 |
| D | HOH698 |
Functional Information from PROSITE/UniProt
| site_id | PS00366 |
| Number of Residues | 28 |
| Details | URICASE Uricase signature. LqLIKVSgNsFvgFirdeYttLpedsnR |
| Chain | Residue | Details |
| A | LEU174-ARG201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Charge relay system; for urate oxidase activity","evidences":[{"source":"UniProtKB","id":"D0VWQ1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"Q00511","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q00511","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of urate oxidase from Bacillus sp.","authoringGroup":["Mycobacterium tuberculosis structural genomics consortium (TB)"]}}]} |
| Chain | Residue | Details |
