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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4XC2

Crystal structure of GABARAP in complex with KBTBD6 LIR peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000139cellular_componentGolgi membrane
A0000421cellular_componentautophagosome membrane
A0000423biological_processmitophagy
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005776cellular_componentautophagosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005930cellular_componentaxoneme
A0006605biological_processprotein targeting
A0006995biological_processcellular response to nitrogen starvation
A0007268biological_processchemical synaptic transmission
A0008429molecular_functionphosphatidylethanolamine binding
A0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
A0012505cellular_componentendomembrane system
A0031410cellular_componentcytoplasmic vesicle
A0031625molecular_functionubiquitin protein ligase binding
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0035020biological_processregulation of Rac protein signal transduction
A0045202cellular_componentsynapse
A0048487molecular_functionbeta-tubulin binding
A0050811molecular_functionGABA receptor binding
A0061709biological_processreticulophagy
A0097352biological_processautophagosome maturation
A0140311molecular_functionprotein sequestering activity
A1902524biological_processpositive regulation of protein K48-linked ubiquitination
A1904262biological_processnegative regulation of TORC1 signaling
A1905673biological_processpositive regulation of lysosome organization
B0000045biological_processautophagosome assembly
B0000139cellular_componentGolgi membrane
B0000421cellular_componentautophagosome membrane
B0000423biological_processmitophagy
B0005515molecular_functionprotein binding
B0005543molecular_functionphospholipid binding
B0005776cellular_componentautophagosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005930cellular_componentaxoneme
B0006605biological_processprotein targeting
B0006995biological_processcellular response to nitrogen starvation
B0007268biological_processchemical synaptic transmission
B0008429molecular_functionphosphatidylethanolamine binding
B0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
B0012505cellular_componentendomembrane system
B0031410cellular_componentcytoplasmic vesicle
B0031625molecular_functionubiquitin protein ligase binding
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0035020biological_processregulation of Rac protein signal transduction
B0045202cellular_componentsynapse
B0048487molecular_functionbeta-tubulin binding
B0050811molecular_functionGABA receptor binding
B0061709biological_processreticulophagy
B0097352biological_processautophagosome maturation
B0140311molecular_functionprotein sequestering activity
B1902524biological_processpositive regulation of protein K48-linked ubiquitination
B1904262biological_processnegative regulation of TORC1 signaling
B1905673biological_processpositive regulation of lysosome organization
C0000045biological_processautophagosome assembly
C0000139cellular_componentGolgi membrane
C0000421cellular_componentautophagosome membrane
C0000423biological_processmitophagy
C0005515molecular_functionprotein binding
C0005543molecular_functionphospholipid binding
C0005776cellular_componentautophagosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005930cellular_componentaxoneme
C0006605biological_processprotein targeting
C0006995biological_processcellular response to nitrogen starvation
C0007268biological_processchemical synaptic transmission
C0008429molecular_functionphosphatidylethanolamine binding
C0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
C0012505cellular_componentendomembrane system
C0031410cellular_componentcytoplasmic vesicle
C0031625molecular_functionubiquitin protein ligase binding
C0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
C0035020biological_processregulation of Rac protein signal transduction
C0045202cellular_componentsynapse
C0048487molecular_functionbeta-tubulin binding
C0050811molecular_functionGABA receptor binding
C0061709biological_processreticulophagy
C0097352biological_processautophagosome maturation
C0140311molecular_functionprotein sequestering activity
C1902524biological_processpositive regulation of protein K48-linked ubiquitination
C1904262biological_processnegative regulation of TORC1 signaling
C1905673biological_processpositive regulation of lysosome organization
D0000045biological_processautophagosome assembly
D0000139cellular_componentGolgi membrane
D0000421cellular_componentautophagosome membrane
D0000423biological_processmitophagy
D0005515molecular_functionprotein binding
D0005543molecular_functionphospholipid binding
D0005776cellular_componentautophagosome
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005930cellular_componentaxoneme
D0006605biological_processprotein targeting
D0006995biological_processcellular response to nitrogen starvation
D0007268biological_processchemical synaptic transmission
D0008429molecular_functionphosphatidylethanolamine binding
D0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
D0012505cellular_componentendomembrane system
D0031410cellular_componentcytoplasmic vesicle
D0031625molecular_functionubiquitin protein ligase binding
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0035020biological_processregulation of Rac protein signal transduction
D0045202cellular_componentsynapse
D0048487molecular_functionbeta-tubulin binding
D0050811molecular_functionGABA receptor binding
D0061709biological_processreticulophagy
D0097352biological_processautophagosome maturation
D0140311molecular_functionprotein sequestering activity
D1902524biological_processpositive regulation of protein K48-linked ubiquitination
D1904262biological_processnegative regulation of TORC1 signaling
D1905673biological_processpositive regulation of lysosome organization
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues63
DetailsRegion: {"description":"Interaction with beta-tubulin","evidences":[{"source":"PubMed","id":"9892355","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues128
DetailsRegion: {"description":"Interaction with GABRG2","evidences":[{"source":"PubMed","id":"9892355","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsRegion: {"description":"Interaction with LIR (LC3 nteracting Region) motif of ATG3","evidences":[{"source":"PubMed","id":"37252361","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AFI","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsSite: {"description":"Interaction with LIR (LC3 nteracting Region) motif of ATG3","evidences":[{"source":"PubMed","id":"37252361","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AFI","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues12
DetailsMotif: {"description":"ATG8 interaction motif (AIM)","evidences":[{"source":"PubMed","id":"25684205","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2026-08-05

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