4XBB

1.85A resolution structure of Norovirus 3CL protease complex with a covalently bound dipeptidyl inhibitor diethyl [(1R,2S)-2-[(N-{[(3-chlorobenzyl)oxy]carbonyl}-3-cyclohexyl-L-alanyl)amino]-1-hydroxy-3-(2-oxo-2H-pyrrol-3-yl)propyl]phosphonate

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis

PDBデータベースに由来する情報

site_id	AC1
残基数	14
詳細	binding site for residue 3ZR A 201

鎖名	残基
A	HIS30
A	VAL168
A	HOH369
A	HOH377
A	HOH379
A	HOH388
A	GLU54
A	GLN110
A	THR134
A	CYS139
A	HIS157
A	ALA158
A	ALA159
A	ALA160

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site_id	AC2
残基数	5
詳細	binding site for residue SO4 A 202

鎖名	残基
A	THR161
A	SER163
A	ASN165
A	THR166
A	HOH424

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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	3
詳細	Active site: {"description":"For 3CLpro activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00870","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16641296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23365454","evidenceCode":"ECO:0000269"}]}

鎖名

残基

詳細

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