4XBB

1.85A resolution structure of Norovirus 3CL protease complex with a covalently bound dipeptidyl inhibitor diethyl [(1R,2S)-2-[(N-{[(3-chlorobenzyl)oxy]carbonyl}-3-cyclohexyl-L-alanyl)amino]-1-hydroxy-3-(2-oxo-2H-pyrrol-3-yl)propyl]phosphonate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 3ZR A 201

Chain	Residue
A	HIS30
A	VAL168
A	HOH369
A	HOH377
A	HOH379
A	HOH388
A	GLU54
A	GLN110
A	THR134
A	CYS139
A	HIS157
A	ALA158
A	ALA159
A	ALA160

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site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 202

Chain	Residue
A	THR161
A	SER163
A	ASN165
A	THR166
A	HOH424

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: For 3CLpro activity => ECO:0000255|PROSITE-ProRule:PRU00870, ECO:0000269|PubMed:16641296, ECO:0000269|PubMed:23365454

Chain	Residue	Details
A	HIS30
A	GLU54
A	CYS139

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by 3CLpro => ECO:0000305|PubMed:17554035, ECO:0000305|PubMed:20976190

Chain	Residue	Details
A	GLU181

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