4X8V

FACTOR VIIA IN COMPLEX WITH THE INHIBITOR (methyl {3-[(2R)-1-{(2R)-2-(3,4-dimethoxyphenyl)-2-[(1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]acetyl}pyrrolidin-2-yl]-4-(propan-2-ylsulfonyl)phenyl}carbamate)

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue 3Z9 H 301

Chain	Residue
H	LEU41
H	SER214
H	TRP215
H	GLY216
H	GLN217
H	GLY219
H	CYS220
H	HOH512
H	HOH513
H	HIS57
H	LYS60
H	GLY97
H	THR99
H	ASP189
H	SER190
H	LYS192
H	SER195

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA H 302

Chain	Residue
H	GLU70
H	ASP72
H	GLU75
H	GLU80
H	HOH413

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 H 303

Chain	Residue
H	ARG83
H	ARG84
H	HIS109
H	GLN110

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 H 304

Chain	Residue
H	VAL35
H	ASN37
H	LYS60
H	LYS60
H	ASN60

---

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 H 305

Chain	Residue
H	ILE47
H	ASN48
H	GLN239
H	MET242
H	HOH436
L	HIS115

---

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL H 306

Chain	Residue
H	PHE59
H	TRP61
H	PRO96
H	ARG147
H	HOH407

---

site_id	AC7
Number of Residues	3
Details	binding site for residue GOL H 307

Chain	Residue
H	LYS20
H	GLU26
H	LEU137

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
H	VAL53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA

Chain	Residue	Details
H	ASP189-ALA200

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC

Chain	Residue	Details
L	CYS112-CYS127

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000250

Chain	Residue	Details
H	HIS57
H	ASP102
H	SER195

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
H	ASP189

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:3264725

Chain	Residue	Details
H	ASN175

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