4X8J

Crystal Structure of murine 12F4 Fab monoclonal antibody against ADAMTS5

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN L 301

Chain	Residue
A	ASP31
H	2PE301
H	HOH401
H	HOH425

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site_id	AC2
Number of Residues	14
Details	binding site for residue 2PE H 301

Chain	Residue
A	TYR104
H	PRO101
H	PHE102
H	HOH401
H	HOH409
H	HOH418
L	TYR49
L	TYR91
L	ZN301
A	VAL2
A	PHE27
A	ASP31
A	ALA32
A	TRP33

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site_id	AC3
Number of Residues	10
Details	binding site for residue 2PE H 302

Chain	Residue
A	TRP33
A	PRO101
A	PHE102
B	TYR49
B	TYR91
H	ASP31
H	TRP33
H	ZN303
H	HOH435
H	HOH478

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site_id	AC4
Number of Residues	2
Details	binding site for residue ZN H 303

Chain	Residue
H	ASP31
H	2PE302

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR192-HIS198

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