4X5A

Anthranilate phosphoribosyltransferase variant R193A from Mycobacterium tuberculosis remains ligand-free when co-crystallised with PRPP and Mg

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000162	biological_process	L-tryptophan biosynthetic process
A	0000287	molecular_function	magnesium ion binding
A	0004048	molecular_function	anthranilate phosphoribosyltransferase activity
A	0005576	cellular_component	extracellular region
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0046872	molecular_function	metal ion binding
B	0000162	biological_process	L-tryptophan biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004048	molecular_function	anthranilate phosphoribosyltransferase activity
B	0005576	cellular_component	extracellular region
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008652	biological_process	amino acid biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 401

Chain	Residue
A	ARG237
A	ARG238
A	LEU305
A	GLY306
A	ILE351
A	ASP352
A	GLU357

---

site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 402

Chain	Residue
A	ALA355
A	ARG362
A	HOH503
A	HOH505
A	HOH513
A	ARG42
A	ALA128

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL B 401

Chain	Residue
B	ASP159
B	PRO180
B	ARG181

---

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL B 402

Chain	Residue
B	THR273
B	PHE274
B	ASP275
B	TRP336

---

site_id	AC5
Number of Residues	9
Details	binding site for residue GOL B 403

Chain	Residue
B	ALA236
B	ARG237
B	ARG238
B	LEU305
B	GLY306
B	GLY307
B	ILE351
B	ASP352
B	GLU357

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00211","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00211","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16337227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23363292","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2011","submissionDatabase":"PDB data bank","title":"Inhibition of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase by blocking of an active site entrance tunnel.","authors":["Castell A.","Short L.F.","Evans G.","Bulloch E.M.","Cookson T.","Parker E.","Lee C.","Baker E.N.","Lott J.S."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"AUG-2012","submissionDatabase":"PDB data bank","title":"Improved inhibitors against Mycobacterium tuberculosis anthranilate phosphoribosyltransferase.","authors":["Evans G.L.","Gamage S.A.","Denny W.A.","Baker E.N.","Lott J.S."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	33
Details	Binding site: {}

Chain

Residue

Details

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