4X4S

Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCACC and CTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000287	molecular_function	magnesium ion binding
A	0001680	biological_process	tRNA 3'-terminal CCA addition
A	0003723	molecular_function	RNA binding
A	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
A	0005524	molecular_function	ATP binding
A	0008033	biological_process	tRNA processing
A	0016779	molecular_function	nucleotidyltransferase activity
A	0031123	biological_process	RNA 3'-end processing
A	0042245	biological_process	RNA repair
A	0046872	molecular_function	metal ion binding
A	0106354	biological_process	tRNA surveillance
A	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity
C	0000049	molecular_function	tRNA binding
C	0000287	molecular_function	magnesium ion binding
C	0001680	biological_process	tRNA 3'-terminal CCA addition
C	0003723	molecular_function	RNA binding
C	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
C	0005524	molecular_function	ATP binding
C	0008033	biological_process	tRNA processing
C	0016779	molecular_function	nucleotidyltransferase activity
C	0031123	biological_process	RNA 3'-end processing
C	0042245	biological_process	RNA repair
C	0046872	molecular_function	metal ion binding
C	0106354	biological_process	tRNA surveillance
C	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue CTP A 501

Chain	Residue
A	SER47
B	C36
B	C37
A	ARG50
A	THR130
A	HIS133
A	TYR161
A	ALA163
A	ARG224
A	MG502
B	A35

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 502

Chain	Residue
A	SER47
A	GLU59
A	ASP61
A	CTP501

---

site_id	AC3
Number of Residues	2
Details	binding site for residue GOL A 503

Chain	Residue
A	ARG209
A	GLU222

---

site_id	AC4
Number of Residues	5
Details	binding site for residue TAR A 504

Chain	Residue
A	HIS240
A	ARG243
C	GLU352
C	VAL355
C	LYS356

---

site_id	AC5
Number of Residues	6
Details	binding site for residue PEG A 505

Chain	Residue
A	PHE349
A	GLU352
A	VAL355
C	HIS240
C	ARG243
C	GLU247

---

site_id	AC6
Number of Residues	3
Details	binding site for residue GOL A 506

Chain	Residue
A	ARG317
A	SER318
C	GLU370

---

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL A 507

Chain	Residue
A	ARG284
A	LYS285
A	ASN403
A	SER407
A	GLU410

---

site_id	AC8
Number of Residues	12
Details	binding site for residue CTP C 501

Chain	Residue
C	SER47
C	ARG50
C	HIS133
C	TYR161
C	ALA163
C	SER171
C	TYR173
C	ARG224
C	MG502
D	A35
D	C36
D	C37

---

site_id	AC9
Number of Residues	4
Details	binding site for residue MG C 502

Chain	Residue
C	SER47
C	GLU59
C	ASP61
C	CTP501

---

site_id	AD1
Number of Residues	2
Details	binding site for residue GOL C 503

Chain	Residue
C	GLU311
C	ARG344

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14592988, ECO:0000269|PubMed:14636575, ECO:0000269|PubMed:25640237, ECO:0007744|PDB:1R89, ECO:0007744|PDB:1UEU, ECO:0007744|PDB:4X4O, ECO:0007744|PDB:4X4Q, ECO:0007744|PDB:4X4S

Chain	Residue	Details
A	SER47
C	SER47

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:14592988, ECO:0000269|PubMed:14636575, ECO:0000269|PubMed:25640237, ECO:0007744|PDB:1R89, ECO:0007744|PDB:1UEU, ECO:0007744|PDB:4X4Q, ECO:0007744|PDB:4X4S

Chain	Residue	Details
A	ARG50
A	HIS133
A	LYS152
A	TYR161
C	ARG50
C	HIS133
C	LYS152
C	TYR161

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14592988, ECO:0007744|PDB:1UEV

Chain	Residue	Details
A	GLU59
C	GLU59

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:14592988, ECO:0007744|PDB:1R89, ECO:0007744|PDB:1UEV

Chain	Residue	Details
A	ASP61
A	ASP110
C	ASP61
C	ASP110

---