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4X2Q

Crystal Structure of Human Aldehyde Dehydrogenase, ALDH1a2

Functional Information from GO Data
ChainGOidnamespacecontents
A0001568biological_processblood vessel development
A0001758molecular_functionretinal dehydrogenase activity
A0001822biological_processkidney development
A0001889biological_processliver development
A0002138biological_processretinoic acid biosynthetic process
A0003007biological_processheart morphogenesis
A0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
A0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006776biological_processvitamin A metabolic process
A0007494biological_processmidgut development
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0009855biological_processdetermination of bilateral symmetry
A0009952biological_processanterior/posterior pattern specification
A0009954biological_processproximal/distal pattern formation
A0010628biological_processpositive regulation of gene expression
A0014032biological_processneural crest cell development
A0016331biological_processmorphogenesis of embryonic epithelium
A0016491molecular_functionoxidoreductase activity
A0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A0016918molecular_functionretinal binding
A0021915biological_processneural tube development
A0021983biological_processpituitary gland development
A0030182biological_processneuron differentiation
A0030324biological_processlung development
A0030326biological_processembryonic limb morphogenesis
A0030900biological_processforebrain development
A0030902biological_processhindbrain development
A0031016biological_processpancreas development
A0031076biological_processembryonic camera-type eye development
A0032355biological_processresponse to estradiol
A0032526biological_processresponse to retinoic acid
A0033189biological_processresponse to vitamin A
A0034097biological_processresponse to cytokine
A0035115biological_processembryonic forelimb morphogenesis
A0035799biological_processureter maturation
A0042572biological_processretinol metabolic process
A0042573biological_processretinoic acid metabolic process
A0042574biological_processretinal metabolic process
A0042904biological_process9-cis-retinoic acid biosynthetic process
A0043010biological_processcamera-type eye development
A0043065biological_processpositive regulation of apoptotic process
A0048384biological_processretinoic acid receptor signaling pathway
A0048471cellular_componentperinuclear region of cytoplasm
A0048566biological_processembryonic digestive tract development
A0048738biological_processcardiac muscle tissue development
A0051289biological_processprotein homotetramerization
A0060324biological_processface development
A0071300biological_processcellular response to retinoic acid
A0090242biological_processobsolete retinoic acid receptor signaling pathway involved in somitogenesis
A1905562biological_processregulation of vascular endothelial cell proliferation
B0001568biological_processblood vessel development
B0001758molecular_functionretinal dehydrogenase activity
B0001822biological_processkidney development
B0001889biological_processliver development
B0002138biological_processretinoic acid biosynthetic process
B0003007biological_processheart morphogenesis
B0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
B0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006776biological_processvitamin A metabolic process
B0007494biological_processmidgut development
B0008283biological_processcell population proliferation
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0009855biological_processdetermination of bilateral symmetry
B0009952biological_processanterior/posterior pattern specification
B0009954biological_processproximal/distal pattern formation
B0010628biological_processpositive regulation of gene expression
B0014032biological_processneural crest cell development
B0016331biological_processmorphogenesis of embryonic epithelium
B0016491molecular_functionoxidoreductase activity
B0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B0016918molecular_functionretinal binding
B0021915biological_processneural tube development
B0021983biological_processpituitary gland development
B0030182biological_processneuron differentiation
B0030324biological_processlung development
B0030326biological_processembryonic limb morphogenesis
B0030900biological_processforebrain development
B0030902biological_processhindbrain development
B0031016biological_processpancreas development
B0031076biological_processembryonic camera-type eye development
B0032355biological_processresponse to estradiol
B0032526biological_processresponse to retinoic acid
B0033189biological_processresponse to vitamin A
B0034097biological_processresponse to cytokine
B0035115biological_processembryonic forelimb morphogenesis
B0035799biological_processureter maturation
B0042572biological_processretinol metabolic process
B0042573biological_processretinoic acid metabolic process
B0042574biological_processretinal metabolic process
B0042904biological_process9-cis-retinoic acid biosynthetic process
B0043010biological_processcamera-type eye development
B0043065biological_processpositive regulation of apoptotic process
B0048384biological_processretinoic acid receptor signaling pathway
B0048471cellular_componentperinuclear region of cytoplasm
B0048566biological_processembryonic digestive tract development
B0048738biological_processcardiac muscle tissue development
B0051289biological_processprotein homotetramerization
B0060324biological_processface development
B0071300biological_processcellular response to retinoic acid
B0090242biological_processobsolete retinoic acid receptor signaling pathway involved in somitogenesis
B1905562biological_processregulation of vascular endothelial cell proliferation
C0001568biological_processblood vessel development
C0001758molecular_functionretinal dehydrogenase activity
C0001822biological_processkidney development
C0001889biological_processliver development
C0002138biological_processretinoic acid biosynthetic process
C0003007biological_processheart morphogenesis
C0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
C0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006629biological_processlipid metabolic process
C0006776biological_processvitamin A metabolic process
C0007494biological_processmidgut development
C0008283biological_processcell population proliferation
C0008284biological_processpositive regulation of cell population proliferation
C0008285biological_processnegative regulation of cell population proliferation
C0009855biological_processdetermination of bilateral symmetry
C0009952biological_processanterior/posterior pattern specification
C0009954biological_processproximal/distal pattern formation
C0010628biological_processpositive regulation of gene expression
C0014032biological_processneural crest cell development
C0016331biological_processmorphogenesis of embryonic epithelium
C0016491molecular_functionoxidoreductase activity
C0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C0016918molecular_functionretinal binding
C0021915biological_processneural tube development
C0021983biological_processpituitary gland development
C0030182biological_processneuron differentiation
C0030324biological_processlung development
C0030326biological_processembryonic limb morphogenesis
C0030900biological_processforebrain development
C0030902biological_processhindbrain development
C0031016biological_processpancreas development
C0031076biological_processembryonic camera-type eye development
C0032355biological_processresponse to estradiol
C0032526biological_processresponse to retinoic acid
C0033189biological_processresponse to vitamin A
C0034097biological_processresponse to cytokine
C0035115biological_processembryonic forelimb morphogenesis
C0035799biological_processureter maturation
C0042572biological_processretinol metabolic process
C0042573biological_processretinoic acid metabolic process
C0042574biological_processretinal metabolic process
C0042904biological_process9-cis-retinoic acid biosynthetic process
C0043010biological_processcamera-type eye development
C0043065biological_processpositive regulation of apoptotic process
C0048384biological_processretinoic acid receptor signaling pathway
C0048471cellular_componentperinuclear region of cytoplasm
C0048566biological_processembryonic digestive tract development
C0048738biological_processcardiac muscle tissue development
C0051289biological_processprotein homotetramerization
C0060324biological_processface development
C0071300biological_processcellular response to retinoic acid
C0090242biological_processobsolete retinoic acid receptor signaling pathway involved in somitogenesis
C1905562biological_processregulation of vascular endothelial cell proliferation
D0001568biological_processblood vessel development
D0001758molecular_functionretinal dehydrogenase activity
D0001822biological_processkidney development
D0001889biological_processliver development
D0002138biological_processretinoic acid biosynthetic process
D0003007biological_processheart morphogenesis
D0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
D0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006629biological_processlipid metabolic process
D0006776biological_processvitamin A metabolic process
D0007494biological_processmidgut development
D0008283biological_processcell population proliferation
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0009855biological_processdetermination of bilateral symmetry
D0009952biological_processanterior/posterior pattern specification
D0009954biological_processproximal/distal pattern formation
D0010628biological_processpositive regulation of gene expression
D0014032biological_processneural crest cell development
D0016331biological_processmorphogenesis of embryonic epithelium
D0016491molecular_functionoxidoreductase activity
D0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D0016918molecular_functionretinal binding
D0021915biological_processneural tube development
D0021983biological_processpituitary gland development
D0030182biological_processneuron differentiation
D0030324biological_processlung development
D0030326biological_processembryonic limb morphogenesis
D0030900biological_processforebrain development
D0030902biological_processhindbrain development
D0031016biological_processpancreas development
D0031076biological_processembryonic camera-type eye development
D0032355biological_processresponse to estradiol
D0032526biological_processresponse to retinoic acid
D0033189biological_processresponse to vitamin A
D0034097biological_processresponse to cytokine
D0035115biological_processembryonic forelimb morphogenesis
D0035799biological_processureter maturation
D0042572biological_processretinol metabolic process
D0042573biological_processretinoic acid metabolic process
D0042574biological_processretinal metabolic process
D0042904biological_process9-cis-retinoic acid biosynthetic process
D0043010biological_processcamera-type eye development
D0043065biological_processpositive regulation of apoptotic process
D0048384biological_processretinoic acid receptor signaling pathway
D0048471cellular_componentperinuclear region of cytoplasm
D0048566biological_processembryonic digestive tract development
D0048738biological_processcardiac muscle tissue development
D0051289biological_processprotein homotetramerization
D0060324biological_processface development
D0071300biological_processcellular response to retinoic acid
D0090242biological_processobsolete retinoic acid receptor signaling pathway involved in somitogenesis
D1905562biological_processregulation of vascular endothelial cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue NAD A 5001
ChainResidue
AILE165
AALA230
APHE243
ASER246
AVAL249
AILE253
AILE166
ATRP168
ALYS192
AALA194
AGLU195
ATYR224
AGLY225
AGLY229

site_idAC2
Number of Residues13
Detailsbinding site for residue NAD B 601
ChainResidue
BILE165
BILE166
BTRP168
BLYS192
BALA194
BGLU195
BGLY225
BGLY229
BALA230
BPHE243
BSER246
BVAL249
BILE253

site_idAC3
Number of Residues14
Detailsbinding site for residue NAD C 601
ChainResidue
CILE165
CILE166
CTRP168
CLYS192
CALA194
CGLU195
CGLY225
CPRO226
CGLY229
CALA230
CPHE243
CSER246
CVAL249
CILE253

site_idAC4
Number of Residues13
Detailsbinding site for residue NAD D 601
ChainResidue
DILE165
DILE166
DTRP168
DLYS192
DALA194
DGLU195
DGLY225
DGLY229
DALA230
DPHE243
DSER246
DVAL249
DILE253

Functional Information from PROSITE/UniProt
site_idPS00070
Number of Residues12
DetailsALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FfNQGQCCTAGS
ChainResidueDetails
APHE295-SER306

site_idPS00687
Number of Residues8
DetailsALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP
ChainResidueDetails
ALEU267-PRO274

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10007, ECO:0000255|PROSITE-ProRule:PRU10008
ChainResidueDetails
AGLU268
BGLU268
CGLU268
DGLU268

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10007, ECO:0000255|PROSITE-ProRule:PRU10008, ECO:0000269|PubMed:29240402
ChainResidueDetails
ACYS302
BCYS302
CCYS302
DCYS302

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:29240402, ECO:0007744|PDB:4X2Q, ECO:0007744|PDB:6ALJ, ECO:0007744|PDB:6B5G, ECO:0007744|PDB:6B5H
ChainResidueDetails
AILE166
ALYS192
BILE166
BLYS192
CILE166
CLYS192
DILE166
DLYS192

site_idSWS_FT_FI4
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:29240402, ECO:0007744|PDB:6ALJ, ECO:0007744|PDB:6B5G, ECO:0007744|PDB:6B5H
ChainResidueDetails
ASER246
DSER246
DLYS348
DGLU399
ALYS348
AGLU399
BSER246
BLYS348
BGLU399
CSER246
CLYS348
CGLU399

site_idSWS_FT_FI5
Number of Residues4
DetailsSITE: Transition state stabilizer => ECO:0000250
ChainResidueDetails
AASN169
BASN169
CASN169
DASN169

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATYR150
BTYR150
CTYR150
DTYR150

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER333
BSER333
CSER333
DSER333

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PDB entries from 2024-07-24

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