4X28

Crystal structure of the ChsE4-ChsE5 complex from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006707	biological_process	cholesterol catabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0016042	biological_process	lipid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0050660	molecular_function	flavin adenine dinucleotide binding
B	0006707	biological_process	cholesterol catabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0016042	biological_process	lipid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
B	0050660	molecular_function	flavin adenine dinucleotide binding
C	0003995	molecular_function	acyl-CoA dehydrogenase activity
C	0006707	biological_process	cholesterol catabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0016042	biological_process	lipid catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
C	0050660	molecular_function	flavin adenine dinucleotide binding
D	0003995	molecular_function	acyl-CoA dehydrogenase activity
D	0006707	biological_process	cholesterol catabolic process
D	0008203	biological_process	cholesterol metabolic process
D	0016042	biological_process	lipid catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
D	0050660	molecular_function	flavin adenine dinucleotide binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	29
Details	binding site for residue FDA A 501

Chain	Residue
A	ILE127
A	GLU382
A	VAL383
A	HOH668
A	HOH680
A	HOH707
A	HOH804
A	HOH821
A	HOH841
A	HOH898
A	HOH899
A	TYR129
C	GLN262
D	ARG251
D	GLN253
D	PHE254
D	ILE258
D	PHE261
D	VAL264
D	HIS327
D	VAL328
D	GLY331
A	SER130
A	GLY135
A	THR136
A	TRP160
A	SER162
A	PHE376
A	THR380

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site_id	AC2
Number of Residues	28
Details	binding site for residue FDA B 501

Chain	Residue
B	ILE127
B	TYR129
B	SER130
B	GLY135
B	THR136
B	TRP160
B	SER162
B	PHE376
B	THR380
B	GLU382
B	VAL383
B	HOH659
B	HOH671
B	HOH672
B	HOH680
B	HOH709
B	HOH777
B	HOH812
B	HOH813
C	ARG251
C	GLN253
C	ILE258
C	PHE261
C	VAL264
C	HIS327
C	VAL328
C	GLY331
D	GLN262

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:26161441, ECO:0007744|PDB:4X28

Chain	Residue	Details
D	ARG251
D	HIS327
D	GLY331
C	ARG251
C	HIS327
C	GLY331

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:26161441, ECO:0007744|PDB:4X28

Chain	Residue	Details
A	ILE127
A	THR136
A	SER162
A	THR380
B	ILE127
B	THR136
B	SER162
B	THR380

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