Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4X23

CRYSTAL STRUCTURE OF CENP-C IN COMPLEX WITH THE NUCLEOSOME CORE PARTICLE

Replaces: 4INM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0030527	molecular_function	structural constituent of chromatin
A	0046982	molecular_function	protein heterodimerization activity
B	0003677	molecular_function	DNA binding
B	0030527	molecular_function	structural constituent of chromatin
B	0046982	molecular_function	protein heterodimerization activity
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0030527	molecular_function	structural constituent of chromatin
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0030527	molecular_function	structural constituent of chromatin
D	0046982	molecular_function	protein heterodimerization activity
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0030527	molecular_function	structural constituent of chromatin
E	0046982	molecular_function	protein heterodimerization activity
F	0003677	molecular_function	DNA binding
F	0030527	molecular_function	structural constituent of chromatin
F	0046982	molecular_function	protein heterodimerization activity
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0030527	molecular_function	structural constituent of chromatin
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0030527	molecular_function	structural constituent of chromatin
H	0046982	molecular_function	protein heterodimerization activity
K	0000786	cellular_component	nucleosome
K	0003677	molecular_function	DNA binding
K	0030527	molecular_function	structural constituent of chromatin
K	0046982	molecular_function	protein heterodimerization activity
L	0003677	molecular_function	DNA binding
L	0030527	molecular_function	structural constituent of chromatin
L	0046982	molecular_function	protein heterodimerization activity
M	0000786	cellular_component	nucleosome
M	0003677	molecular_function	DNA binding
M	0030527	molecular_function	structural constituent of chromatin
M	0046982	molecular_function	protein heterodimerization activity
N	0000786	cellular_component	nucleosome
N	0003677	molecular_function	DNA binding
N	0030527	molecular_function	structural constituent of chromatin
N	0046982	molecular_function	protein heterodimerization activity
O	0000786	cellular_component	nucleosome
O	0003677	molecular_function	DNA binding
O	0030527	molecular_function	structural constituent of chromatin
O	0046982	molecular_function	protein heterodimerization activity
P	0003677	molecular_function	DNA binding
P	0030527	molecular_function	structural constituent of chromatin
P	0046982	molecular_function	protein heterodimerization activity
Q	0000786	cellular_component	nucleosome
Q	0003677	molecular_function	DNA binding
Q	0030527	molecular_function	structural constituent of chromatin
Q	0046982	molecular_function	protein heterodimerization activity
R	0000786	cellular_component	nucleosome
R	0003677	molecular_function	DNA binding
R	0030527	molecular_function	structural constituent of chromatin
R	0046982	molecular_function	protein heterodimerization activity
U	0000776	cellular_component	kinetochore
U	0019237	molecular_function	centromeric DNA binding
U	0051382	biological_process	kinetochore assembly
V	0000776	cellular_component	kinetochore
V	0019237	molecular_function	centromeric DNA binding
V	0051382	biological_process	kinetochore assembly
W	0000776	cellular_component	kinetochore
W	0019237	molecular_function	centromeric DNA binding
W	0051382	biological_process	kinetochore assembly
X	0000776	cellular_component	kinetochore
X	0019237	molecular_function	centromeric DNA binding
X	0051382	biological_process	kinetochore assembly

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA20-VAL26

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:22389435

Chain	Residue	Details
D	LYS43
R	LYS43
R	LYS113
R	LYS117
P	LYS31
P	LYS77
P	LYS79
P	LYS91
D	LYS113
D	LYS117
H	LYS43
H	LYS113
H	LYS117
N	LYS43
N	LYS113
N	LYS117

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
D	SER109
H	SER109
N	SER109
R	SER109
L	THR80
L	THR82
P	THR80
P	THR82

site_id	SWS_FT_FI3
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305

Chain	Residue	Details
D	LYS117
H	LYS117
N	LYS117
R	LYS117

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)