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4X1G

Crystal structure of the hPXR-LBD in complex with the synthetic estrogen 17alpha-ethinylestradiol and the pesticide trans-nonachlor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue 3WF A 501
ChainResidue
AASP205
A3WG502
ALEU206
ALEU240
ASER247
APHE251
AHIS407
AARG410
AILE414
AMET425

site_idAC2
Number of Residues9
Detailsbinding site for residue 3WG A 502
ChainResidue
AMET243
APHE281
AGLN285
APHE288
ATRP299
ATYR306
AMET323
AHIS407
A3WF501

site_idAC3
Number of Residues4
Detailsbinding site for residue MPD A 503
ChainResidue
AGLU337
ATYR340
AARG387
AHOH670

site_idAC4
Number of Residues3
Detailsbinding site for residue IPA A 504
ChainResidue
ALYS160
AASP163
AHOH695

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:12578355, ECO:0007744|PDB:1M13
ChainResidueDetails
ASER247
AGLN285
AHIS407

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PDB entries from 2024-12-18

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