4X08
Structure of H128N/ECP mutant in complex with sulphate anions at 1.34 Angstroms.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001530 | molecular_function | lipopolysaccharide binding |
| A | 0002227 | biological_process | innate immune response in mucosa |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0006935 | biological_process | chemotaxis |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0043152 | biological_process | induction of bacterial agglutination |
| A | 0045087 | biological_process | innate immune response |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| B | 0001530 | molecular_function | lipopolysaccharide binding |
| B | 0002227 | biological_process | innate immune response in mucosa |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004540 | molecular_function | RNA nuclease activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006401 | biological_process | RNA catabolic process |
| B | 0006935 | biological_process | chemotaxis |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019731 | biological_process | antibacterial humoral response |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0043152 | biological_process | induction of bacterial agglutination |
| B | 0045087 | biological_process | innate immune response |
| B | 0050829 | biological_process | defense response to Gram-negative bacterium |
| B | 0050830 | biological_process | defense response to Gram-positive bacterium |
| B | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 201 |
| Chain | Residue |
| A | ARG1 |
| A | ARG7 |
| A | ARG101 |
| A | HOH439 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | HOH317 |
| A | HOH380 |
| A | HOH434 |
| B | ARG104 |
| B | HOH356 |
| A | ARG34 |
| A | LYS38 |
| A | HOH304 |
| A | HOH305 |
| A | HOH307 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 203 |
| Chain | Residue |
| A | ARG77 |
| A | ARG104 |
| A | HOH324 |
| B | TRP35 |
| B | ARG36 |
| B | HOH302 |
| B | HOH369 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 204 |
| Chain | Residue |
| A | ARG121 |
| A | ARG121 |
| A | HOH310 |
| A | HOH310 |
| A | HOH314 |
| A | HOH314 |
| A | HOH319 |
| A | HOH319 |
| A | HOH367 |
| B | PRO123 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 205 |
| Chain | Residue |
| A | ARG28 |
| A | ASN32 |
| A | ARG61 |
| A | ARG66 |
| A | SO4207 |
| A | HOH312 |
| A | HOH313 |
| B | ARG22 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 206 |
| Chain | Residue |
| A | ASN53 |
| A | VAL54 |
| A | ASN57 |
| A | SER74 |
| A | ARG75 |
| A | PHE76 |
| A | HOH302 |
| A | HOH448 |
| A | HOH453 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 207 |
| Chain | Residue |
| A | ARG28 |
| A | ARG61 |
| A | SO4205 |
| A | HOH303 |
| A | HOH494 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 201 |
| Chain | Residue |
| B | ARG1 |
| B | ARG101 |
| B | HOH305 |
| B | HOH330 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 202 |
| Chain | Residue |
| A | ARG104 |
| B | ARG34 |
| B | LYS38 |
| B | ASN39 |
| B | HOH303 |
| B | HOH307 |
| B | HOH348 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 B 203 |
| Chain | Residue |
| A | ASN53 |
| A | ARG75 |
| B | ASN87 |
| B | PRO88 |
| B | GLY89 |
| B | HOH301 |
| B | HOH320 |
| B | HOH328 |
| B | HOH336 |
| B | HOH357 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 204 |
| Chain | Residue |
| A | ASN57 |
| A | GLN58 |
| A | ARG75 |
| B | ASN87 |
| B | ARG97 |
| B | HOH351 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 205 |
| Chain | Residue |
| A | ARG36 |
| B | ARG77 |
| B | ARG104 |
| B | HOH304 |
| site_id | AD4 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 B 206 |
| Chain | Residue |
| B | ASN57 |
| B | GLN58 |
| B | ARG73 |
| B | ARG75 |
| B | ARG75 |
| B | HOH309 |
| B | HOH319 |
| B | HOH378 |
| B | HOH422 |
| B | HOH431 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 207 |
| Chain | Residue |
| B | HOH442 |
| A | GLN58 |
| A | SER59 |
| B | ARG97 |
| B | HOH310 |
| B | HOH349 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 208 |
| Chain | Residue |
| A | ARG22 |
| B | ARG28 |
| B | ASN32 |
| B | ARG61 |
| B | ARG66 |
| B | HOH306 |
| B | HOH311 |
| B | HOH379 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 209 |
| Chain | Residue |
| B | GLN58 |
| B | SER59 |
| B | ARG75 |
| B | HOH308 |
| B | HOH315 |
| B | HOH362 |
| B | HOH381 |
| B | HOH486 |
Functional Information from PROSITE/UniProt
| site_id | PS00127 |
| Number of Residues | 7 |
| Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKnqNTF |
| Chain | Residue | Details |
| A | CYS37-PHE43 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 88 |
| Details | Region: {"description":"Required for nearly all of the bactericidal activity; partially involved in LPS-binding and bacterial membrane depolarization"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"May be involved in LPS-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"May be involved in LPS- and LTA-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"PubMed","id":"18694936","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
