4WZH
Dihydroorotate dehydrogenase from Leishmania Viannia braziliensis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006222 | biological_process | UMP biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006222 | biological_process | UMP biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue FMN A 401 |
| Chain | Residue |
| A | ALA19 |
| A | LYS165 |
| A | ILE194 |
| A | ASN195 |
| A | GLY223 |
| A | CYS249 |
| A | GLY250 |
| A | GLY251 |
| A | GLY272 |
| A | THR273 |
| A | HOH541 |
| A | ALA20 |
| A | HOH577 |
| A | GLY21 |
| A | LYS44 |
| A | SER45 |
| A | TYR59 |
| A | ASN68 |
| A | MET70 |
| A | ASN128 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue EPE A 402 |
| Chain | Residue |
| A | ILE7 |
| A | LEU8 |
| A | GLN189 |
| A | PRO242 |
| A | LYS244 |
| A | LEU245 |
| A | HOH508 |
| A | HOH527 |
| A | HOH530 |
| B | ILE7 |
| B | LEU8 |
| B | PRO242 |
| B | LYS244 |
| B | LEU245 |
| B | HOH542 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | binding site for residue FMN B 401 |
| Chain | Residue |
| B | ALA19 |
| B | ALA20 |
| B | GLY21 |
| B | LYS44 |
| B | SER45 |
| B | TYR59 |
| B | ASN68 |
| B | MET70 |
| B | ASN128 |
| B | LYS165 |
| B | ILE194 |
| B | ASN195 |
| B | GLY223 |
| B | CYS249 |
| B | GLY250 |
| B | GLY251 |
| B | GLY272 |
| B | THR273 |
| B | HOH562 |
| B | HOH570 |
| B | HOH587 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| A | ASP171 |
| A | PHE172 |
| A | ALA173 |
| B | ASN199 |
| B | LYS215 |
