4WWX

Crystal structure of the core RAG1/2 recombinase

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004519	molecular_function	endonuclease activity
B	0033151	biological_process	V(D)J recombination
B	0043565	molecular_function	sequence-specific DNA binding
B	0061630	molecular_function	ubiquitin protein ligase activity
E	0004519	molecular_function	endonuclease activity
E	0033151	biological_process	V(D)J recombination
E	0043565	molecular_function	sequence-specific DNA binding
E	0061630	molecular_function	ubiquitin protein ligase activity
X	0003677	molecular_function	DNA binding
X	0005634	cellular_component	nucleus
X	0006310	biological_process	DNA recombination
Y	0003677	molecular_function	DNA binding
Y	0005634	cellular_component	nucleus
Y	0006310	biological_process	DNA recombination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN B 1101

Chain	Residue
B	CYS727
B	CYS730
B	HIS937
B	HIS942

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN E 1101

Chain	Residue
E	CYS727
E	CYS730
E	HIS937
E	HIS942

---

Functional Information from PROSITE/UniProt

site_id	PS00435
Number of Residues	11
Details	PEROXIDASE_1 Peroxidases proximal heme-ligand signature. DTVYILGGHSL

Chain	Residue	Details
X	ASP214-LEU224

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Essential for DNA hairpin formation, participates in base-stacking interactions near the cleavage site"}

Chain

Residue

Details

---