Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4WW5

Crystal structure of binary complex Bud32-Cgi121 in complex with AMPP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000282	biological_process	cellular bud site selection
A	0000408	cellular_component	EKC/KEOPS complex
A	0000722	biological_process	telomere maintenance via recombination
A	0000723	biological_process	telomere maintenance
A	0000781	cellular_component	chromosome, telomeric region
A	0002949	biological_process	tRNA threonylcarbamoyladenosine modification
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004676	molecular_function	3-phosphoinositide-dependent protein kinase activity
A	0004677	molecular_function	DNA-dependent protein kinase activity
A	0004679	molecular_function	AMP-activated protein kinase activity
A	0004694	molecular_function	eukaryotic translation initiation factor 2alpha kinase activity
A	0004711	molecular_function	ribosomal protein S6 kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006338	biological_process	chromatin remodeling
A	0006468	biological_process	protein phosphorylation
A	0008033	biological_process	tRNA processing
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0035175	molecular_function	histone H3S10 kinase activity
A	0035402	molecular_function	histone H3T11 kinase activity
A	0035403	molecular_function	histone H3T6 kinase activity
A	0035979	molecular_function	histone H2AXS139 kinase activity
A	0044022	molecular_function	histone H3S28 kinase activity
A	0044023	molecular_function	histone H4S1 kinase activity
A	0044024	molecular_function	histone H2AS1 kinase activity
A	0044025	molecular_function	histone H2BS14 kinase activity
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0070525	biological_process	tRNA threonylcarbamoyladenosine metabolic process
A	0072354	molecular_function	histone H3T3 kinase activity
A	0072371	molecular_function	histone H2AS121 kinase activity
A	0072518	molecular_function	Rho-dependent protein serine/threonine kinase activity
A	0106310	molecular_function	protein serine kinase activity
A	0140823	molecular_function	histone H2BS36 kinase activity
A	0140855	molecular_function	histone H3S57 kinase activity
A	0140857	molecular_function	histone H3T45 kinase activity
A	1990145	biological_process	maintenance of translational fidelity
A	1990244	molecular_function	histone H2AT120 kinase activity
B	0000049	molecular_function	tRNA binding
B	0000408	cellular_component	EKC/KEOPS complex
B	0000722	biological_process	telomere maintenance via recombination
B	0000723	biological_process	telomere maintenance
B	0000781	cellular_component	chromosome, telomeric region
B	0002949	biological_process	tRNA threonylcarbamoyladenosine modification
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005829	cellular_component	cytosol
B	0006310	biological_process	DNA recombination
B	0008033	biological_process	tRNA processing
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	1990145	biological_process	maintenance of translational fidelity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ANP A 301

Chain	Residue
A	ILE50
A	GLY184
A	HOH470
A	HOH479
A	LYS52
A	ARG72
A	GLU107
A	PHE108
A	LEU109
A	PHE119
A	ASP182
A	PHE183

site_id	AC2
Number of Residues	4
Details	binding site for residue ACT A 302

Chain	Residue
A	LEU199
A	GLU203
A	ASN218
A	ILE221

site_id	AC3
Number of Residues	3
Details	binding site for residue ACT A 303

Chain	Residue
A	GLU203
A	LEU207
A	ARG251

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 304

Chain	Residue
A	SER135
A	ASP136
A	ARG253
A	ARG257
A	HOH405

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 A 305

Chain	Residue
A	ARG143
A	LYS216
A	TRP220
A	GLU223

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL A 306

Chain	Residue
A	CYS90
A	VAL91
A	GLU107
A	HIS179
A	HOH480
B	ARG170

site_id	AC7
Number of Residues	4
Details	binding site for residue ACT B 201

Chain	Residue
B	TYR145
B	GLU147
B	GLN163
B	ASP164

site_id	AC8
Number of Residues	8
Details	binding site for residue SO4 B 204

Chain	Residue
A	TYR100
B	GLU63
B	ASN67
B	ARG70
B	ARG143
B	HOH304
B	HOH305
B	HOH306

site_id	AC9
Number of Residues	6
Details	binding site for residues SO4 B 202 and SO4 B 203

Chain	Residue
B	LYS68
B	ILE134
B	GLU135
B	ASN140
B	HOH307
B	HOH357

Functional Information from PROSITE/UniProt

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YCHgDLTSSNIVL

Chain	Residue	Details
A	TYR157-LEU169

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP161

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE22
A	LYS43

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269\|PubMed:12023889

Chain	Residue	Details
A	SER187
A	SER189

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)