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4WVS

Crystal structure of XIAP-BIR2 domain complexed with (S)-3-(4-methoxyphenyl)-2-((S)-2-((S)-1-((S)-2-((S)-2-(methylamino)propanamido)pent-4-ynoyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)propanoic acid

Functional Information from GO Data
ChainGOidnamespacecontents
A0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
A0043066biological_processnegative regulation of apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 501
ChainResidue
ACYS200
ACYS203
AHIS220
ACYS227

site_idAC2
Number of Residues7
Detailsbinding site for residue SO4 A 502
ChainResidue
AASN226
APHE228
AHIS-2
AGLY-3
AGLU164
AALA202
ACYS203

site_idAC3
Number of Residues6
Detailsbinding site for residue SO4 A 503
ChainResidue
AGLN197
ALYS208
AASN209
AHOH606
AHOH607
AHOH609

site_idAC4
Number of Residues3
Detailsbinding site for residue GOL A 504
ChainResidue
ALYS206
BPHE4
B4LZ5

site_idAC5
Number of Residues4
Detailsbinding site for residue SO4 A 505
ChainResidue
ACYS203
AGLY205
APHE224
AASN226

Functional Information from PROSITE/UniProt
site_idPS01282
Number of Residues68
DetailsBIR_REPEAT_1 BIR repeat. EeaRlksfqn.Wpdyahltprelas.AGLyYtgigDqvqCfaCggklknWepgdrawseHrrhfPnCffV
ChainResidueDetails
AGLU163-VAL230

227561

PDB entries from 2024-11-20

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