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4WVL

Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement

Functional Information from GO Data
ChainGOidnamespacecontents
A0031151molecular_functionhistone H3K79 methyltransferase activity
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue 3US A 401
ChainResidue
AASP161
AASP222
APHE223
AASN241
APHE245
AHOH529
ALEU162
AGLY163
ASER164
AGLY165
AVAL169
AGLU186
ALYS187
AGLY221

site_idAC2
Number of Residues4
Detailsbinding site for residue SO4 A 402
ChainResidue
AARG203
ALYS207
AHIS213
AHOH567

site_idAC3
Number of Residues2
Detailsbinding site for residue SO4 A 403
ChainResidue
AHIS117
AGLU201

site_idAC4
Number of Residues3
Detailsbinding site for residue SO4 A 404
ChainResidue
AHIS251
ALYS254
AARG343

site_idAC5
Number of Residues4
Detailsbinding site for residue GOL A 405
ChainResidue
AVAL160
ATYR183
AARG231
ATHR235

site_idAC6
Number of Residues4
Detailsbinding site for residue EDO A 406
ChainResidue
AGLU46
ALYS97
ASER103
ALYS211

site_idAC7
Number of Residues3
Detailsbinding site for residue EDO A 407
ChainResidue
AASN99
ATHR100
AARG101

site_idAC8
Number of Residues2
Detailsbinding site for residue EDO A 408
ChainResidue
AARG292
AVAL294

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
ATYR136
APHE159
AGLU186
AASP222

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER297

222415

PDB entries from 2024-07-10

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